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Dr. Sushil Kumar Singh

Professor
Department of Pharmaceutical Engineering and Technology
Phone No(s): 9415812970
Email: sksingh.phe@iitbhu.ac.in
Area of Interest: Pharmaceutical Chemistry
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  • Ganeshpurkar A, Singh R, Tripathi P, Alam Q, Krishnamurthy S, Kumar A, Singh SK. Effect of sulfonamide derivatives of phenylglycine on scopolamine‐induced amnesia in rats. ibrain. 2023;1–19. DOI: 10.1002/ibra.12092.
  • Ganeshpurkar A, Singh R, Kumar D, Gutti G, Sardana D, Shivhare S, Singh RB, Kumar A, Singh SK. Development of homology model, docking protocol and Machine-Learning based scoring functions for identification of Equus caballus’s butyrylcholinesterase inhibitors. Journal of Biomolecular Structure and Dynamics. 2022 Dec 26;40(24):13693-710.
  • Ghosh P, Singh R, Ganeshpurkar A, Swetha R, Kumar D, Singh SK, Kumar A. Identification of potential death-associated protein kinase-1 (DAPK1) inhibitors by an integrated ligand-based and structure-based computational drug design approach. Journal of Biomolecular Structure and Dynamics. 2022 Dec 15:1-3.
  • Firdaus Z, Kumar D, Singh SK, Singh TD. Centella asiatica alleviates AlCl3-induced cognitive impairment, oxidative stress, and neurodegeneration by modulating cholinergic activity and oxidative burden in rat brain. Biological Trace Element Research. 2022 Dec;200(12):5115-26.
  • Ramakrishna K, Singh SK, Krishnamurthy S. Diindolylmethane Ameliorates Ischemic Stroke-Induced Brain Injury by Peripheral and Central Mechanisms. Current Neurovascular Research. 2022 Oct 1;19(5):462-75.
  • Swetha R, Sharma A, Singh R, Ganeshpurkar A, Kumar D, Kumar A, Singh SK. Combined ligand-based and structure-based design of PDE 9A inhibitors against Alzheimer’s disease. Molecular Diversity. 2022 Oct;26(5):2877-92.
  • Tripathi P, Ganeshpurkar A, Singh SK, Krishnamurthy S. Generation of wild-type rat Glucocerebrosidase homology modeling: Identification of putative interactions site and mechanism for chaperone using combined in-silico and in-vitro studies. Bioorganic Chemistry. 2022 Sep 1;126:105871.
  • Bajad NG, Swetha R, Singh R, Ganeshpurkar A, Gutti G, Singh RB, Kumar A, Singh SK. Combined structure and ligand-based design of dual BACE-1/GSK-3β inhibitors for Alzheimer’s disease. Chemical Papers. 2022 Aug 23:1-8.
  • Sharma A, Swetha R, Bajad NG, Ganeshpurkar A, Singh R, Kumar A, Singh SK. Cathepsin BA Neuronal Death Mediator in Alzheimer’s Disease Leading to Neurodegeneration. Mini Reviews in Medicinal Chemistry. 2022 Aug 1;22(15):2012-23.
  • Bajad NG, Singh SK, Singh SK, Singh TD, Singh M. Indole: A promising scaffold for the discovery and development of potential anti-tubercular agents. Current Research in Pharmacology and Drug Discovery. 2022 Jul 16:100119.
  • Singh R, Pokle AV, Ghosh P, Ganeshpurkar A, Swetha R, Singh SK, Kumar A. Pharmacophore-based virtual screening, molecular docking and molecular dynamics simulations study for the identification of LIM kinase-1 inhibitors. Journal of Biomolecular Structure and Dynamics. 2022 Jul 13:1-5.
  • Ganeshpurkar A, Singh R, Kumar D, Gutti G, Gore P, Sahu B, Kumar A, Singh SK. Identification of sulfonamide-based butyrylcholinesterase inhibitors using machine learning. Future Medicinal Chemistry. 2022 Jul;14(14):1049-70.
  • Rai H, Gupta S, Kumar S, Yang J, Singh SK, Ran C, Modi G. Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid-Beta and Tau Aggregates in Alzheimer’s Disease. Journal of Medicinal Chemistry. 2022 Jun 27;65(13):8550-95.
  • Ganeshpurkar A, Singh R, Kumar D, Gore P, Shivhare S, Sardana D, Rayala S, Kumar A, Singh SK. Identification of sulfonamide based butyrylcholinesterase inhibitors through scaffold hopping approach. International Journal of Biological Macromolecules. 2022 Apr 1;203:195-211.
  • Bajad NG, Swetha R, Gutti G, Singh M, Kumar A, Singh SK. A systematic review of carbohydrate-based bioactive molecules for Alzheimer’s disease. Future Medicinal Chemistry. 2021 Jul;13(19):1695-711.
  • Ganeshpurkar A, Singh R, Singh RB, Kumar D, Kumar A, Singh SK. Identification of potential AChE inhibitors through combined machine-learning and structure-based design approaches. NIScPR (2022)
  • Ganeshpurkar A, Singh R, Shivhare S, Kumar D, Gutti G, Singh R, Kumar A, Singh SK. Improved machine learning scoring functions for identification of Electrophorus electricus’s acetylcholinesterase inhibitors. Molecular Diversity. 2021 Jul 30:1-25.
  • Firdaus Z, Singh SK, Singh TD, Singh M. The scientific community in COVID-19 global pandemic: A systematic update on recent progress and challenges. European Journal of Chemistry. 2021 Jun 30;12(2):222-34.
  • Makar S, Ghosh A, Shivhare S, Kumar A, Singh SK. Molecular Processes Involved in Pancreatic Cancer and Therapeutics. Current Chemical Biology. 2021 Mar 1;15(1):85-108.
  • Bajad NG, Rayala S, Gutti G, Sharma A, Singh M, Kumar A, Singh SK. Systematic review on role of structure based drug design (SBDD) in the identification of anti-viral leads against SARS-Cov-2. Current Research in Pharmacology and Drug Discovery. 2021 Jan 1;2:100026.
  • Ganeshpurkar A, Singh R, Kumar D, Divya, Shivhare S, Kumar A, Singh SK. Computational binding study with α7 nicotinic acetylcholine receptor of Anvylic-3288: an allosteric modulator. Molecular Simulation. 2020 Sep 1;46(13):975-86.
  • Modi A, Singh M, Gutti G, Shanker OR, Singh VK, Singh S, Singh SK, Pradhan S, Narayan G. Benzothiazole derivative bearing amide moiety induces p53-mediated apoptosis in HPV16 positive cervical cancer cells. Investigational New Drugs. 2020 Aug;38:934-45.
  • Singh R, Ganeshpurkar A, Kumar D, Kumar D, Kumar A, Singh SK. Identifying potential GluN2B subunit containing N-Methyl-D-aspartate receptor inhibitors: An integrative in silico and molecular modeling approach. Journal of Biomolecular Structure and Dynamics. 2020 Jun 12;38(9):2533-45.
  • Singh RB, Das N, Singh GK, Singh SK, Zaman K. Synthesis and pharmacological evaluation of 3-[5-(aryl-[1, 3, 4] oxadiazole-2-yl]-piperidine derivatives as anticonvulsant and antidepressant agents. Arabian Journal of Chemistry. 2020 May 1;13(5):5299-311.
  • Makar S, Ghosh A, Kumar A, Singh SK. Recent studies on aromatase and sulfatase involved in breast cancer and their inhibitors. Current Enzyme Inhibition. 2020 Apr 1;16(1):20-44.
  • Ganeshpurkar, A., Singh, R., Gore, P. G., Kumar, D., Gutti, G., Kumar, A., & Singh, S. K. (2020). Structure-based screening and molecular dynamics simulation studies for the identification of potential acetylcholinesterase inhibitors. Molecular Simulation, 46(3), 169-185.
  • John TS, Yadav PK, Kumar D, Singh SK, Hasan SH. Highly fluorescent carbon dots from wheat bran as a novel drug delivery system for bacterial inhibition. Luminescence. 2020 Sep;35(6):913-23.
  • Siddamurthi S, Gutti G, Jana S, Kumar A, Singh SK. Anthraquinone: a promising scaffold for the discovery and development of therapeutic agents in cancer therapy. Future medicinal chemistry. 2020 Mar;12(11):1037-69.
  • Ganeshpurkar A, Makar S, Kumar D, Jana S, Singh SK. Aspartic proteases: Potential drug targets for anticancer drug development. InCancer-Leading Proteases 2020 Jan 1 (pp. 121-163). Academic Press.
  • Makar S, Saha T, Swetha R, Gutti G, Kumar A, Singh SK. Rational approaches of drug design for the development of selective estrogen receptor modulators (SERMs), implicated in breast cancer. Bioorganic Chemistry. 2020 Jan 1;94:103380.
  • Swetha R, Kumar D, Gupta SK, Ganeshpurkar A, Singh R, Gutti G, Kumar D, Jana S, Krishnamurthy S, Singh SK. Multifunctional hybrid sulfonamides as novel therapeutic agents for Alzheimer’s disease. Future Medicinal Chemistry. 2019 Dec;11(24):3161-78.
  • Gutti G, Kakarla R, Kumar D, Beohar M, Ganeshpurkar A, Kumar A, Krishnamurthy S, Singh SK. Discovery of novel series of 2-substituted benzo [d] oxazol-5-amine derivatives as multi-target directed ligands for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry. 2019 Nov 15;182:111613.
  • Gutti G, Arya K, Singh SK. Latent tuberculosis infection (LTBI) and its potential targets: An investigation into dormant phase pathogens. Mini Reviews in Medicinal Chemistry. 2019 Nov 1;19(19):1627-42.
  • Gutti G, Kumar D, Paliwal P, Ganeshpurkar A, Lahre K, Kumar A, Krishnamurthy S, Singh SK. Development of pyrazole and spiropyrazoline analogs as multifunctional agents for treatment of Alzheimer’s disease. Bioorganic Chemistry. 2019 Sep 1;90:103080.
  • Saha T, Makar S, Swetha R, Gutti G, Singh SK. Estrogen signaling: An emanating therapeutic target for breast cancer treatment. European Journal of Medicinal Chemistry. 2019 Sep 1;177:116-43.
  • Mahapatra DK, Bharti SK, Asati V, Singh SK. Perspectives of medicinally privileged chalcone based metal coordination compounds for biomedical applications. European journal of medicinal chemistry. 2019 Jul 15;174:142-58.
  • Jana S, Singh SK. Identification of human tau-tubulin kinase 1 inhibitors: An integrated e-pharmacophore-based virtual screening and molecular dynamics simulation. Journal of Biomolecular Structure and Dynamics. 2019 Apr 2.
  • Sellamuthu S, Kumar A, Nath G, Singh SK. Design, Synthesis and Biological Profiling of Novel Phenothiazine Derivatives as Potent Antitubercular Agents.  Anti-Infective Agents. 2019;17 (1):50-65
  • Jana S, Singh SK. Identification of selective MMP-9 inhibitors through multiple e-pharmacophore, ligand-based pharmacophore, molecular docking, and density functional theory approaches. Journal of Biomolecular Structure and Dynamics. 2019 Mar 4;37(4):944-65.
  • Ganeshpurkar A, Swetha R, Kumar D, Gangaram GP, Singh R, Gutti G, Jana S, Kumar D, Kumar A, Singh SK. Protein-protein interactions and aggregation inhibitors in Alzheimer’s disease. Current topics in medicinal chemistry. 2019 Mar 1;19(7):501-33.
  • Kumar D, Gupta SK, Ganeshpurkar A, Singh R, Kumar D, Das N, Singh SK, et al. Biological profiling of piperazinediones for the management of anxiety.  Pharmacol Biochem Behav. 2019;176:63-71
  • Ganeshpurkar A, Gutti G, Singh SK. Chapter 1 - RNA-Dependent RNA Polymerases and Their Emerging Roles in Antiviral Therapy. In: Gupta SP, editor. Viral Polymerases: Academic Press; 2019: 1-42
  • Makar S, Saha T, Singh SK. Naphthalene, a versatile platform in medicinal chemistry: Sky-high perspective. Eur. J. Med. Chem. 2019;161:252-76
  • Ganeshpurkar A, Kumar D, Singh SK. Design, synthesis and collagenase inhibitory activity of some novel phenylglycine derivatives as metalloproteinase inhibitors. Int J Biol Macromol.​ 2018;107:1491-500
  • Jana S, Ganeshpurkar A, Singh SK. Multiple 3D-QSAR modeling, e-pharmacophore, molecular docking, and in vitro study to explore novel AChE inhibitors. RSC adv. 2018;8(69):39477-95
  • Kumar D, Ganeshpurkar A, Kumar D, Modi GP, Gupta SK, Singh SK. Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead.Eur. J. Med. Chem. 2018 ;148:436-452
  • Kumar D, Gupta SK, Ganeshpurkar A, Gutti G, Krishnamurthy S, Modi G, et al. Development of Piperazinediones as dual inhibitor for treatment of Alzheimer's disease.Eur. J. Med. Chem. 2018;150:87-101
  • Satheeshkumar S, Mohammad F B, Ashok K, Gopal N, Singh SK. Design, Synthesis and Biological Evaluation of Carbazole Derivatives as Antitubercular and Antibacterial Agents.  Curr Bioact Compd 2018;14:1-15
  • Sellamuthu S, Asseri AH, Goojani HG, Nath G, Singh SK. Preliminary Studies on Ligand-based Design and Evaluation of New Mycobacterial ATP Synthase Inhibitors. Curr Drug Deliv​. 2018;13(1):56-73
  • Sellamuthu S, Gutti G, Kumar D, Kumar D, Singh SK. Carbazole: A Potent Scaffold for Antitubercular Drugs. Mini Rev Org Chem. 2018;15(6):498-507
  • Sellamuthu S, Kumar A, Singh SK. De novo drug design, pharmacophore search and molecular docking for inhibitors to treat TB and HIV co-infection. International Journal of Computational Biology and Drug Design. 2019;12(3):230-50.
  • Singh RB, Singh GK, Chaturvedi K, Kumar D, Singh SK, Zaman MK. Design, synthesis, characterization, and molecular modeling studies of novel oxadiazole derivatives of nipecotic acid as potential anticonvulsant and antidepressant agents. Med Chem Res. 2018;27(1):137-52
  • Swetha R, Gayen C, Kumar D, Singh TD, Modi G, Singh SK. Biomolecular basis of matrix metallo proteinase-9 activity. Future Med. Chem. 2018;10(9):1093-112
  • Ankit G, Devendra K, Singh SK. Strategies for the Synthesis of Hydroxamic Acids. Curr Org Synth. 2018;15(2):154-65
  • Sellamuthu S, Bhat MF, Kumar A, Singh SK. Phenothiazine: A better Scaffold against Tuberculosis. Mini Rev Med Chem. 2018; 18(17) :1442-1451
  • Singh SK, Dutta A, Modi G. α-Synuclein aggregation modulation: an emerging approach for the treatment of Parkinson's disease. Future Med Chem. 2017;9(10):1039-53
  • Sellamuthu S, Singh M, Kumar A, Singh SK. Type-II NADH Dehydrogenase (NDH-2): a promising therapeutic target for antitubercular and antibacterial drug discovery. Expert Opin Ther Targets​. 2017 ;21(6):559-570
  • Singh M, Singh SK, Gangwar M, Nath G, Singh SK. Design, synthesis and mode of action of novel 2-(4-aminophenyl) benzothiazole derivatives bearing semicarbazone and thiosemicarbazone moiety as potent antimicrobial agents. Med Chem Res. 2016;25(2):263-282
  • Singh M, Modi A, Narayan G, Singh SK. Benzothiazole derivatives bearing amide moiety: potential cytotoxic and apoptosis-inducing agents against cervical cancer. Anti-cancer drugs. 2016;27(6):519-532
  • Singh M, Kumar Singh S, Thakur B, Ray P, Singh SK. Design and synthesis of novel Schiff base-benzothiazole hybrids as potential epidermal growth factor receptor (EGFR) inhibitors. Anticancer Agents Med Chem (Formerly Current Medicinal Chemistry-Anti-Cancer Agents). 2016;16(6):722-739
  • Singh M, Kumar Singh S, Gangwar M, Sellamuthu S, Nath G, Singh SK. Design, synthesis and mode of action of some new 2-(4'-aminophenyl) benzothiazole derivatives as potent antimicrobial agents. Lett Drug Des Discov. 2016;13(5):429-437
  • Singh SK, Chouhan HS, Sahu AN, Narayan G. Assessment of in vitro antipsoriatic activity of selected Indian medicinal plants. Pharm Biol. 2015;53(9):1295-1301
  • Bharti SK, Mahapatra D, Singh SK. Thiazole: A Simple Scaffold with Tremendous Therapeutic Potential. Chemical and Biochemical Engineering: New Materials and Developed Components. Apple academic press. 2015:43.
  • Singh M, Singh SK, Gangwar M, Nath G, Singh SK. Design, synthesis and mode of action of some benzothiazole derivatives bearing an amide moiety as antibacterial agents. RSC adv. 2014;4(36):19013-19023
  • Singh M, Singh SK. Benzothiazoles: how relevant in cancer drug design strategy? Anticancer Agents Med Chem (Formerly Current Medicinal Chemistry-Anti-Cancer Agents). 2014;14(1):127-146
  • Singh M, Gangwar M, Nath G, Singh SK. Synthesis, DNA cleavage and antimicrobial activity of 4-thiazolidinones-benzothiazole conjugates. Indian J Exp Biol. 2014; 52: 1062-1070
  • Kumar D, BG H, Gangwar M, Kumar M, Kumar D, Tilak R, Singh SK., et al. Synthesis, molecular docking and in vitro antimicrobial studies of novel pyrazole analogues of curcumin.Lett Drug Des Discov 2014;11(4):474-483
  • Singh M, Singh SK., T Chhabria M, Vasu K, Pandya D. CoMFA and CoMSIA 3D QSAR Models for a Series of Some Condensed Thieno -2, 3-d- pyrimidin-4 (3H)-ones with Antihistaminic (H1) Activity. Med Chem. 2013;9(3):389-401
  • Saravanan C, Punitha AD, Srivastava AK, Nath G, Singh SK. Antibacterial activity of novel 2-(substituted sulfonamido) benzoic acid derivatives.  J. Pharm. Res. 2013;7(6):525-538
  • Kumar D, Kumar M, Kumar A, Kumar Singh S. Chalcone and curcumin derivatives: a way ahead for malarial treatment. Mini Rev Med Chem.​ 2013;13(14):2116-2133
  • Kumar D, BG H, Gangwar M, Kumar M, Kumar D, Nath G, Singh. SK, et al. Synthesis, molecular docking and in vitro antimicrobial studies of new hexahydroindazole derivatives of curcumin. Lett Drug Des Discov. 2013;10(2):119-128
  • Jain P, Saravanan C, Singh SK. Sulphonamides: deserving class as MMP inhibitors? Eur. J. Med. Chem. 2013;60:89-100
  • Gangwar M, Verma VC, Singh TD, Singh SK, Goel R, Nath G. In-vitro scolicidal activity of Mallotus philippinensis (Lam.) Muell Arg. fruit glandular hair extract against hydatid cyst Echinococcus granulosus. Asian Pac J Trop Biomed.​ 2013;6(8):595-601
  • Sridevi V, Chouhan HS, Singh NK, Singh SK. Antioxidant and hepatoprotective effects of ethanol extract of Vitex glabrata on carbon tetrachloride-induced liver damage in rats. Nat. Prod. Res. 2012;26(12):1135-1140
  • Singh M, Singh SK, Chhabria MT. A novel QSAR model for evaluating and predicting the inhibition activity of H1-receptor antagonists: a series of thienopyrimidine derivatives. J. Drug Deliv. Ther. 2012;2(1).6-15
  • Kumar D, Kumar M, Saravanan C, Singh SK. Curcumin: a potential candidate for matrix metalloproteinase inhibitors. Expert Opin Ther Targets​. 2012;16(10):959-972
  • Gangwar M, Dalai A, Chaudhary A, Singh T, Singh SK, Goel R, et al. Study on activity of alcoholic extract of glands and hairs of fruits of Mallotus philippinensis in murine cestodal infection model. Int J Pharm Pharm Sci. 2012;4:643-655
  • Chouhan HS, Sridevi K, Singh NK, Singh SK. Anti-inflammatory activity of ethanol extract of Vitex glabrata leaves. Pak J Pharm Sci. 2012;25(1):131-144
  • Bhattamisra SK, Singh PN, Singh SK. Effect of standardized extract of Marsilea minuta on learning and memory performance in rat amnesic models. Pharm biol. 2012;50(6):766-772
  • Saravanan C, Singh SK. Status of research on MMPs in India. Expert Opin Ther Targets​. 2011;15(6):715-728
  • Chouhan HS, Singh SK. Phytochemical analysis, antioxidant and anti-inflammatory activities of Phyllanthus simplex. J Ethnopharmacol. 2011;137(3):1337-1344
  • Chouhan HS, Singh SK. A review of plants of genus Leucas. J Pharmacogn Phytochem 2011;3(2):13-26
  • Chouhan HS, Sahu AN, Singh SK. Fatty acid composition, antioxidant, anti-inflammatory and antibacterial activities of seed oil from Crotalaria juncea Linn. J. Med. Plants Res. 2011;5(6):984-991
  • Chouhan HS, Singh SK. Antibacterial activity of seed and flower parts of Crotalaria juncea Linn. Am-Eurasian J Sci Res. 2010;5(3):212-5
  • Chouhan HS, Singh SK. Synthesis and characterization of some Mannich bases as potential antimicrobial agents. Asian J. Chem. 2010;22(10):7903-7908
  • Bharti SK, Patel SK, Nath G, Tilak R, Singh SK. Synthesis, characterization, DNA cleavage and in vitro antimicrobial activities of copper (II) complexes of Schiff bases containing a 2, 4-disubstituted thiazole. Transition Met. Chem. 2010;35(8):917-725
  • Bharti SK, Nath G, Tilak R, Singh S. Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2, 4-disubstituted thiazole ring. Eur. J. Med. Chem. 2010;45(2):651-660
  • Singh S, Prabha T, Kavitha B, Chouhan H, Bharti SK., Singh SK., Anti-inflammatory and hepatoprotective activities of ethanolic extract of Euphorbia thymifolia Linn. Pharmacologyonline. 2009;1:986-94
  • Shabeer J, Srivastava RS, Singh SK. Antidiabetic and antioxidant effect of various fractions of Phyllanthus simplex in alloxan diabetic rats. J. Ethnopharmacol. 2009;124(1):34-8
  • Bharti SK, Singh SK. Metal based drugs: Current use and future potential. Pharm Lett. 2009;1(2):39-51
  • Bhattamisra SK, Khanna VK, Agrawal AK, Singh PN, Singh SK. Antidepressant activity of standardised extract of Marsilea minuta Linn. J. Ethnopharmacol. 2008;117(1):51-57
  • Jasemine S, Srivastava RS, Singh SK. Hepatoprotective Effect of Crude Extract and Isolated Lignans of Justicia simplex. against CCl4-Induced Hepatotoxicity. Pharm. Biol. 2007;45(4):274-277
  • Bhattamisra S, Singh P, Singh SK., Kumar V. Anxiolytic activity of Marsilea minuta Linn in rodents. Journal of Herbal Medicine and Toxicology. 2007;1(1):15-20
  • Bhattamisra S, Singh P, Singh SK. Behavioural characterization of Marsilea minuta in rodents. Indian J Nat Prod. 2006;22:3-7
  • Bhasin P, Sachdeva N, Pandeya S, Nath G, Singh SK., Synthesis and evaluation of Schiff and N-Mannich bases of isatin as potential antimicrobial agents. Acta Pharm Sci​. 2005;47(1)
  • Balasundari P, Singh S, Kavimani S. Free radical scavenging of xanthones from Swertia chirata Buchham and tumor cell growth inhibition. Main Group Chem. 2005;4(3):177-85
  • Amir M, Kumar S, Singh S. Chemical and biological review of Phyllanthus niruri. Nat. Prod. Updates, 2004;19(4):3-13
  • Kumar K, Singh S, Pandeya S. Synthesis and antibacterial activity of pyridyl thioureas and arylthiosemicarbazones. Boll Chim Farm. 2001;140(4):238-242
  • Srivedi VK, Elayraja, A. and Singh SK. Free radicals are they real villain?. The Pharmstudent. 2003;24:68-72
  • Singh SK, Vidyarthi, D.P.  Pharma-informatics an emerging trend in Pharmaceutical Study. The Pharmstudent. 2003;24:39-41
  • Kumar K, Singh SK, Pandeya S. Synthesis and antibacterial activity of pyridyl thioureas and arylthiosemicarbazones. Boll Chim Farm. 2001;140(4):238-242
  • Ghosal S, Sundaram R, Muruganandam A, Singh SK, Satyan K, Bhattacharya S, et al. The chemistry and action of 6-alkylsalicylates of Indian Ginkgo biloba. Indian J. Chem., Sect B. 1997;36(3):257-263
  • Ghosal S, Lal J, Singh SK, Goel RK, Jaiswal AK, Bhattacharya SK. The need for formulation of Shilajit by its isolated active constituents.Phytother Res. 1991;5(5):211-6
  • Ghosal S, Lal J, Singh SK. The core structure of Shilajit humus. Soil Biol. Biochem. 1991;23(7):673-680
  • Ghosal S, Datta K, Singh SK, Kumar Y. Significance of Amaryllidaceae alkaloids in a unique plant-insect interaction. Indian J. Chem., Sect B. 1991;30(2):260-264
  • Ghosal S, Datta, K., Singh SK., and Kumar, Y. Telastaside, a Stress-Related Alkaloid-Conjugate from Polytela gloriosa. J Chem Research(s). 1990 :334-335
  • Ghosal S, Singh SK, Unnikrishnan SG. Effects of stress on alkaloid metabolism in Crinum asiaticum. Phytochemistry. 1990;29(3):805-811
  • Ghosal S. Singh SK. Mangicrocin an Adaptogenic Xanthone Carotenoid Glycosidic Conjugate from Saffron. J Chem Research(s). 1989:70-1
  • Ghosal S, Lal, J., Singh, SK, Kumar, Y., and Soti, F. Chemistry of two  bioactive benzopyrone metabolites,. J Chem Research(s). 1989:350-1
  • Ghosal S, Lal J, Singh SK, Dasgupta G, Bhaduri J, Mukhopadhyay M, et al. Mast cell protecting effects of shilajit and its constituents. Phytotherapy Research. 1989;3(6):249-252
  • Ghosal S, Mittal P, Kumar Y, Singh SK. Free and glucosyloxy acetophenones from Pancratium biflorum. Phytochemistry. 1989;28(11):3193-6
  • Ghosal S, Unnikrishnan S, Singh SK. Occurrence of two epimeric alkaloids and metabolism compared with lycorine in Crinum latifolium. Phytochemistry. 1989;28(9):2535-2357
  • Ghosal S, Shanthy A, Singh SK. Isocraugsodine, an n-arylidenephenethylamine from Crinum asiaticum and its ez isomerism. Phytochemistry. 1988;27(6):1849-52
  • Ghosal S, Singh S, Srivastava R. Shilajit. II: Biphenyl metabolites from Trifolium repens. J. Chem. Res., Synop. 1988(6):196-7
  • Ghosal S, Singh SK, Kumar Y, Srivastava R, Goel RK, Dey R, et al. Anti‐ulcerogenic activity of fulvic acids and 4′‐methoxy‐6‐carbomethoxybiphenyl isolated from shilajit. Phytother. Res​. 1988;2(4):187-91
  • Ghosal S, Singh SK, Kumar Y, Unnikrishnan S, Chattopadhyay S. The role of ungeremine in the growth-inhibiting and cytotoxic effects of lycorine: evidence and speculation. Planta medica. 1988;54(02):114-6
  • Ghosal S, Singh SK, Unnikrishnan SG. Phosphatidylpyrrolophenanthridine alkaloids from Zephyranthes flava. Phytochemistry. 1987;26(3):823-8
  • Ghosal S, Kumar, Y., Singh, SK., and Shanthy, A. The occurrence of N- (3-Hydroxy-4-methoxybenzylidine)-4- hydroxyphenethylamine in Crinum augustum and its biogenetic significance. J Chem Research(s). 1986:28-9.
  • Ghosal S, Kumar, Y., Singh, SK. and Kumar, A. Ungeremine and criasbetaine two anti – tumor alkaloids from Crinum asiaticum. J Chem Research(s). 1986:112-3
  • Ghosal S, Kumar Y, Chakrabarti DK, Lal J, Singh SK. Parasitism of Imperata cylindrica on Pancratium biflorum and the concomitant chemical changes in the host species. Phytochemistry. 1986;25(5):1097-102
  • Ghosal S, Kumar Y, Singh SK, Kumar A. Chemical Constituents of Amaryllidaceae. Part 21. Ungeremine and Criasbetaine, Two Anti‐tumour Alkaloids from Crinum asiaticum. Indian J. of chem​. 1986;17(33):112-113
  • Ghosal S, Kumar Y, Singh SK, Shanthy A. Chemical constituents of amaryllidaceae. XIX: The occurrence of N-(3-hydroxy-4-methoxybenzylidene)-4'-hydroxyphenethylamine in Crinum augustum and its biogenetic significance. J. Chem. Res., Synop. 1986(1):28-9
  • Ghosal S, Singh SK, Srivastava RS. Alkaloids of Zephyranthes flava. Phytochemistry. 1986;25(8):1975-8
  • Ghosal S, Biswas K, Saini K, Singh S. Regioselective Cleavage Of Methylenedioxy Ring In Xanthones: An Entry Into Immuno‐Stimulant 7‐Glucosyloxypolymethoxyxanthones.Indian J. of chem​. 1985;16(21):106-107
  • Ghosal S, Jaiswal DK, Singh SK, Srivastava RS. Dichotosin and dichotosinin, two adaptogenic glucosyloxy flavans from Hoppea dichotoma. Phytochemistry. 1985;24(4):831-3
  • Ghosal S, Singh SK, Srivastava RS. Flavans from Zephyranthes flava. Phytochemistry. 1985;24(1):151-3

Drug Development through Design and synthesis of new chemical entities & isolation of active constituents from Medicinal plants for major diseases/disorders of human by both conventional and advanced techniques

  • Design and synthesis of novel Matrix Metallo Proteinase (MMP-2 & 9) Inhibitors as Therapeutic Agents for Alzheimer’s Disease Funded by DBT, New Delhi( Completed-Major:PI)
  • Isolation of marker compounds from natural sources funded by Drug Research & Development Centre, Kolkata( Completed-Minor:PI)
  • Isolation of marker compounds from Withania somnifera funded by Natreon Inc, Kolkata (Completed-Minor:PI)
  • Ethno medicinal plants as a source of new therapeutic agents against psoriasis Funded by NMPB,AYUSH New Delhi(Completed-Major:PI)
  • Cestocidal activity of glands and hairs of fruits of Mallotus phillippinensis (Kampillaka Plant) funded by ICMR, New Delhi(Completed- Major::Co-PI)
  • M Pharm Students: 46 (completed)
  • Ph D Students: 13 (completed); 03 (ongoing)
  • Organizing secretary, Pharmaco-Therapeutics and Formulation Development (PTFD-2005), Varanasi.
  • Joint Secretary and chairman Registration committee, 59th Indian Pharmaceutical Congress held at Varanasi during Dec 2007
  • Organizing Chairman, Emerging Trends in Drug Discovery & Development(ETDDD-2018), Varanasi

S.No.

Title

Inventor Name

Status

1

A Pharmaceutical Composition of Sulfonamide derivatives for the Treatment of Alzheimer’s Disease.

Prof. Sushil Kumar Singh,

Dr. Gyan Prakash Modi,

Dr. Devendra Kumar,

Ms. Swetha Rayala,

Mr. Chadrim Gayen,

Mr. Ankit Ganeshpurkar

Granted

Patent no. 404586

 

2

Novel Quinolinyl piperazine derivatives as dual inhibitors of β secretase (BACE1) and acetylcholine esterase (AChE) for the management of Alzheimer’s disease.

Prof. Sushil Kumar Singh,

Dr. Ashok Kumar,

Dr. Dileep Kumar,

Dr. Devendra Kumar,

Mr. Gopichand Gutti,

Mr. Ankit Ganeshpurkar

Application filed

Application No.

201911032481

Date of filing: 10/8/2019

3

Novel sulfonamide derivatives of para amino benzoic acid as selective Butrylcholinesterase (BuChE) inhibitors for the treatment of Alzheimer’s disease. 

Prof. Sushil Kumar Singh,

Dr. Ashok Kumar,

Mr. Ankit Ganeshpurkar

Dr. Devendra Kumar,

Mr. Ravi Singh,

Mr. Gore Pravin Gangaram

Mr. Gopichand Gutti

Application filed

Application No.

201911044199

Date of filing: 31/10/2019

4

Multitarget-directed triazole bridged cycloaryl analogues for treatment of Alzheimer’s disease

Prof. Sushil Kumar Singh,

Dr. Ashok Kumar,

Mr. Gopichand Gutti

Mr. Ankit Ganeshpurkar

Dr. Devendra Kumar,

Mr. Ravi Singh,

Application filed

Application No.

202011047641

Date of filing: 31/10/2020