sksingh.phe's picture
Dr. Sushil Kumar Singh
Professor
Department of Pharmaceutical Engineering and Technology IIT BHU
sksingh.phe@iitbhu.ac.in
9415812970
Area of Interest: 
Pharmaceutical Chemistry

 
  • Sellamuthu S, Kumar A, Nath G, Singh SK. Design, Synthesis and Biological Profiling of Novel Phenothiazine Derivatives as Potent Antitubercular Agents.  Anti-Infective Agents. 2019;17 (1):50-65
  • Kumar D, Gupta SK, Ganeshpurkar A, Singh R, Kumar D, Das N, Singh SK, et al. Biological profiling of piperazinediones for the management of anxiety.  Pharmacol Biochem Behav. 2019;176:63-71
  • Ganeshpurkar A, Gutti G, Singh SK. Chapter 1 - RNA-Dependent RNA Polymerases and Their Emerging Roles in Antiviral Therapy. In: Gupta SP, editor. Viral Polymerases: Academic Press; 2019: 1-42
  • Makar S, Saha T, Singh SK. Naphthalene, a versatile platform in medicinal chemistry: Sky-high perspective. Eur. J. Med. Chem. 2019;161:252-76
  • Ganeshpurkar A, Kumar D, Singh SK. Design, synthesis and collagenase inhibitory activity of some novel phenylglycine derivatives as metalloproteinase inhibitors. Int J Biol Macromol.​ 2018;107:1491-500
  • Jana S, Ganeshpurkar A, Singh SK. Multiple 3D-QSAR modeling, e-pharmacophore, molecular docking, and in vitro study to explore novel AChE inhibitors. RSC adv. 2018;8(69):39477-95
  • Jana S, Singh SK. Identification of selective MMP-9 inhibitors through multiple e-pharmacophore, ligand-based pharmacophore, molecular docking, and density functional theory approaches. J Biomol Struct Dyn.  2018:1-22
  • Kumar D, Ganeshpurkar A, Kumar D, Modi GP, Gupta SK, Singh SK. Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead.Eur. J. Med. Chem. 2018 ;148:436-452
  • Kumar D, Gupta SK, Ganeshpurkar A, Gutti G, Krishnamurthy S, Modi G, et al. Development of Piperazinediones as dual inhibitor for treatment of Alzheimer's disease.Eur. J. Med. Chem. 2018;150:87-101
  • Satheeshkumar S, Mohammad F B, Ashok K, Gopal N, Singh SK. Design, Synthesis and Biological Evaluation of Carbazole Derivatives as Antitubercular and Antibacterial Agents.  Curr Bioact Compd 2018;14:1-15
  • Sellamuthu S, Asseri AH, Goojani HG, Nath G, Singh SK. Preliminary Studies on Ligand-based Design and Evaluation of New Mycobacterial ATP Synthase Inhibitors. Curr Drug Deliv​. 2018;13(1):56-73
  • Sellamuthu S, Gutti G, Kumar D, Kumar D, Singh SK. Carbazole: A Potent Scaffold for Antitubercular Drugs. Mini Rev Org Chem. 2018;15(6):498-507
  • Sellamuthu S, Kumar A, Singh SK. De novo Drug Design, Pharmacophore Search and Molecular Docking for Inhibitors to treat TB and HIV co-infection. Int J Comput Biol Drug Des. 2018 (in press)
  • Singh RB, Singh GK, Chaturvedi K, Kumar D, Singh SK, Zaman MK. Design, synthesis, characterization, and molecular modeling studies of novel oxadiazole derivatives of nipecotic acid as potential anticonvulsant and antidepressant agents. Med Chem Res. 2018;27(1):137-52
  • Swetha R, Gayen C, Kumar D, Singh TD, Modi G, Singh SK. Biomolecular basis of matrix metallo proteinase-9 activity. Future Med. Chem. 2018;10(9):1093-112
  • Ankit G, Devendra K, Singh SK. Strategies for the Synthesis of Hydroxamic Acids. Curr Org Synth. 2018;15(2):154-65
  • Sellamuthu S, Bhat MF, Kumar A, Singh SK. Phenothiazine: A better Scaffold against Tuberculosis. Mini Rev Med Chem. 2018; 18(17) :1442-1451
  • Singh SK, Dutta A, Modi G. α-Synuclein aggregation modulation: an emerging approach for the treatment of Parkinson's disease. Future Med Chem. 2017;9(10):1039-53
  • Sellamuthu S, Singh M, Kumar A, Singh SK. Type-II NADH Dehydrogenase (NDH-2): a promising therapeutic target for antitubercular and antibacterial drug discovery. Expert Opin Ther Targets​. 2017 ;21(6):559-570
  • Singh M, Singh SK, Gangwar M, Nath G, Singh SK. Design, synthesis and mode of action of novel 2-(4-aminophenyl) benzothiazole derivatives bearing semicarbazone and thiosemicarbazone moiety as potent antimicrobial agents. Med Chem Res. 2016;25(2):263-282
  • Singh M, Modi A, Narayan G, Singh SK. Benzothiazole derivatives bearing amide moiety: potential cytotoxic and apoptosis-inducing agents against cervical cancer. Anti-cancer drugs. 2016;27(6):519-532
  • Singh M, Kumar Singh S, Thakur B, Ray P, Singh SK. Design and synthesis of novel Schiff base-benzothiazole hybrids as potential epidermal growth factor receptor (EGFR) inhibitors. Anticancer Agents Med Chem (Formerly Current Medicinal Chemistry-Anti-Cancer Agents). 2016;16(6):722-739
  • Singh M, Kumar Singh S, Gangwar M, Sellamuthu S, Nath G, Singh SK. Design, synthesis and mode of action of some new 2-(4'-aminophenyl) benzothiazole derivatives as potent antimicrobial agents. Lett Drug Des Discov. 2016;13(5):429-437
  • Singh SK, Chouhan HS, Sahu AN, Narayan G. Assessment of in vitro antipsoriatic activity of selected Indian medicinal plants. Pharm Biol. 2015;53(9):1295-1301
  • Bharti SK, Mahapatra D, Singh SK. Thiazole: A Simple Scaffold with Tremendous Therapeutic Potential. Chemical and Biochemical Engineering: New Materials and Developed Components. Apple academic press. 2015:43.
  • Singh M, Singh SK, Gangwar M, Nath G, Singh SK. Design, synthesis and mode of action of some benzothiazole derivatives bearing an amide moiety as antibacterial agents. RSC adv. 2014;4(36):19013-19023
  • Singh M, Singh SK. Benzothiazoles: how relevant in cancer drug design strategy? Anticancer Agents Med Chem (Formerly Current Medicinal Chemistry-Anti-Cancer Agents). 2014;14(1):127-146
  • Singh M, Gangwar M, Nath G, Singh SK. Synthesis, DNA cleavage and antimicrobial activity of 4-thiazolidinones-benzothiazole conjugates. Indian J Exp Biol2014; 52: 1062-1070
  • Kumar D, BG H, Gangwar M, Kumar M, Kumar D, Tilak R, Singh SK., et al. Synthesis, molecular docking and in vitro antimicrobial studies of novel pyrazole analogues of curcumin.Lett Drug Des Discov 2014;11(4):474-483
  • Singh M, Singh SK., T Chhabria M, Vasu K, Pandya D. CoMFA and CoMSIA 3D QSAR Models for a Series of Some Condensed Thieno -2, 3-d- pyrimidin-4 (3H)-ones with Antihistaminic (H1) Activity. Med Chem. 2013;9(3):389-401
  • Saravanan C, Punitha AD, Srivastava AK, Nath G, Singh SK. Antibacterial activity of novel 2-(substituted sulfonamido) benzoic acid derivatives.  J. Pharm. Res. 2013;7(6):525-538
  • Kumar D, Kumar M, Kumar A, Kumar Singh S. Chalcone and curcumin derivatives: a way ahead for malarial treatment. Mini Rev Med Chem.​ 2013;13(14):2116-2133
  • Kumar D, BG H, Gangwar M, Kumar M, Kumar D, Nath G, Singh. SK, et al. Synthesis, molecular docking and in vitro antimicrobial studies of new hexahydroindazole derivatives of curcumin. Lett Drug Des Discov. 2013;10(2):119-128
  • Jain P, Saravanan C, Singh SK. Sulphonamides: deserving class as MMP inhibitors? Eur. J. Med. Chem. 2013;60:89-100
  • Gangwar M, Verma VC, Singh TD, Singh SK, Goel R, Nath G. In-vitro scolicidal activity of Mallotus philippinensis (Lam.) Muell Arg. fruit glandular hair extract against hydatid cyst Echinococcus granulosus. Asian Pac J Trop Biomed.​ 2013;6(8):595-601
  • Sridevi V, Chouhan HS, Singh NK, Singh SK. Antioxidant and hepatoprotective effects of ethanol extract of Vitex glabrata on carbon tetrachloride-induced liver damage in rats. Nat. Prod. Res. 2012;26(12):1135-1140
  • Singh M, Singh SK, Chhabria MT. A novel QSAR model for evaluating and predicting the inhibition activity of H1-receptor antagonists: a series of thienopyrimidine derivatives. J. Drug Deliv. Ther. 2012;2(1).6-15
  • Kumar D, Kumar M, Saravanan C, Singh SK. Curcumin: a potential candidate for matrix metalloproteinase inhibitors. Expert Opin Ther Targets​. 2012;16(10):959-972
  • Gangwar M, Dalai A, Chaudhary A, Singh T, Singh SK, Goel R, et al. Study on activity of alcoholic extract of glands and hairs of fruits of Mallotus philippinensis in murine cestodal infection model. Int J Pharm Pharm Sci. 2012;4:643-655
  • Chouhan HS, Sridevi K, Singh NK, Singh SK. Anti-inflammatory activity of ethanol extract of Vitex glabrata leaves. Pak J Pharm Sci. 2012;25(1):131-144
  • Bhattamisra SK, Singh PN, Singh SK. Effect of standardized extract of Marsilea minuta on learning and memory performance in rat amnesic models. Pharm biol. 2012;50(6):766-772
  • Saravanan C, Singh SK. Status of research on MMPs in India. Expert Opin Ther Targets​. 2011;15(6):715-728
  • Chouhan HS, Singh SK. Phytochemical analysis, antioxidant and anti-inflammatory activities of Phyllanthus simplex. J Ethnopharmacol. 2011;137(3):1337-1344
  • Chouhan HS, Singh SK. A review of plants of genus Leucas. J Pharmacogn Phytochem 2011;3(2):13-26
  • Chouhan HS, Sahu AN, Singh SK. Fatty acid composition, antioxidant, anti-inflammatory and antibacterial activities of seed oil from Crotalaria juncea Linn. J. Med. Plants Res. 2011;5(6):984-991
  • Chouhan HS, Singh SK. Antibacterial activity of seed and flower parts of Crotalaria juncea Linn. Am-Eurasian J Sci Res. 2010;5(3):212-5
  • Chouhan HS, Singh SK. Synthesis and characterization of some Mannich bases as potential antimicrobial agents. Asian J. Chem. 2010;22(10):7903-7908
  • Bharti SK, Patel SK, Nath G, Tilak R, Singh SK. Synthesis, characterization, DNA cleavage and in vitro antimicrobial activities of copper (II) complexes of Schiff bases containing a 2, 4-disubstituted thiazole. Transition Met. Chem. 2010;35(8):917-725
  • Bharti SK, Nath G, Tilak R, Singh S. Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2, 4-disubstituted thiazole ring. Eur. J. Med. Chem. 2010;45(2):651-660
  • Singh S, Prabha T, Kavitha B, Chouhan H, Bharti SK., Singh SK., Anti-inflammatory and hepatoprotective activities of ethanolic extract of Euphorbia thymifolia Linn. Pharmacologyonline. 2009;1:986-94
  • Shabeer J, Srivastava RS, Singh SK. Antidiabetic and antioxidant effect of various fractions of Phyllanthus simplex in alloxan diabetic rats. J. Ethnopharmacol. 2009;124(1):34-8
  • Bharti SK, Singh SK. Metal based drugs: Current use and future potential. Pharm Lett. 2009;1(2):39-51
  • Bhattamisra SK, Khanna VK, Agrawal AK, Singh PN, Singh SK. Antidepressant activity of standardised extract of Marsilea minuta Linn. J. Ethnopharmacol. 2008;117(1):51-57
  • Jasemine S, Srivastava RS, Singh SK. Hepatoprotective Effect of Crude Extract and Isolated Lignans of Justicia simplex. against CCl4-Induced Hepatotoxicity. Pharm. Biol. 2007;45(4):274-277
  • Bhattamisra S, Singh P, Singh SK., Kumar V. Anxiolytic activity of Marsilea minuta Linn in rodents. Journal of Herbal Medicine and Toxicology. 2007;1(1):15-20
  • Bhattamisra S, Singh P, Singh SK. Behavioural characterization of Marsilea minuta in rodents. Indian J Nat Prod. 2006;22:3-7
  • Bhasin P, Sachdeva N, Pandeya S, Nath G, Singh SK., Synthesis and evaluation of Schiff and N-Mannich bases of isatin as potential antimicrobial agents. Acta Pharm Sci​. 2005;47(1)
  • Balasundari P, Singh S, Kavimani S. Free radical scavenging of xanthones from Swertia chirata Buchham and tumor cell growth inhibition. Main Group Chem. 2005;4(3):177-85
  • Amir M, Kumar S, Singh S. Chemical and biological review of Phyllanthus niruri. Nat. Prod. Updates, 2004;19(4):3-13
  • Kumar K, Singh S, Pandeya S. Synthesis and antibacterial activity of pyridyl thioureas and arylthiosemicarbazones. Boll Chim Farm. 2001;140(4):238-242
  • Srivedi VK, Elayraja, A. and Singh SK. Free radicals are they real villain?. The Pharmstudent. 2003;24:68-72
  • Singh SK, Vidyarthi, D.P.  Pharma-informatics an emerging trend in Pharmaceutical Study. The Pharmstudent. 2003;24:39-41
  • Kumar K, Singh SK, Pandeya S. Synthesis and antibacterial activity of pyridyl thioureas and arylthiosemicarbazones. Boll Chim Farm. 2001;140(4):238-242
  • Ghosal S, Sundaram R, Muruganandam A, Singh SK, Satyan K, Bhattacharya S, et al. The chemistry and action of 6-alkylsalicylates of Indian Ginkgo biloba. Indian J. Chem., Sect B. 1997;36(3):257-263
  • Ghosal S, Lal J, Singh SK, Goel RK, Jaiswal AK, Bhattacharya SK. The need for formulation of Shilajit by its isolated active constituents.Phytother Res. 1991;5(5):211-6
  • Ghosal S, Lal J, Singh SK. The core structure of Shilajit humus. Soil Biol. Biochem. 1991;23(7):673-680
  • Ghoshal S, Datta K, Singh SK, Kumar Y. Significance of Amaryllidaceae alkaloids in a unique plant-insect interaction. Indian J. Chem., Sect B. 1991;30(2):260-264
  • Ghosal S, Datta, K., Singh SK., and Kumar, Y. Telastaside, a Stress-Related Alkaloid-Conjugate from Polytela gloriosa. J Chem Research(s). 1990 :334-335
  • Ghosal S, Singh SK, Unnikrishnan SG. Effects of stress on alkaloid metabolism in Crinum asiaticum. Phytochemistry. 1990;29(3):805-811
  • Ghosal S. Singh SK. Mangicrocin an Adaptogenic Xanthone Carotenoid Glycosidic Conjugate from Saffron. J Chem Research(s). 1989:70-1
  • Ghosal S, Lal, J., Singh, SK, Kumar, Y., and Soti, F. Chemistry of two  bioactive benzopyrone metabolites,. J Chem Research(s). 1989:350-1
  • Ghosal S, Lal J, Singh SK, Dasgupta G, Bhaduri J, Mukhopadhyay M, et al. Mast cell protecting effects of shilajit and its constituents. Phytotherapy Research. 1989;3(6):249-252
  • Ghosal S, Mittal P, Kumar Y, Singh SK. Free and glucosyloxy acetophenones from Pancratium biflorum. Phytochemistry. 1989;28(11):3193-6
  • Ghosal S, Unnikrishnan S, Singh SK. Occurrence of two epimeric alkaloids and metabolism compared with lycorine in Crinum latifolium. Phytochemistry. 1989;28(9):2535-2357
  • Ghosal S, Shanthy A, Singh SK. Isocraugsodine, an n-arylidenephenethylamine from Crinum asiaticum and its ez isomerism. Phytochemistry. 1988;27(6):1849-52
  • Ghosal S, Singh S, Srivastava R. Shilajit. II: Biphenyl metabolites from Trifolium repens. J. Chem. Res., Synop. 1988(6):196-7
  • Ghosal S, Singh SK, Kumar Y, Srivastava R, Goel RK, Dey R, et al. Anti‐ulcerogenic activity of fulvic acids and 4′‐methoxy‐6‐carbomethoxybiphenyl isolated from shilajit. Phytother. Res​. 1988;2(4):187-91
  • Ghosal S, Singh SK, Kumar Y, Unnikrishnan S, Chattopadhyay S. The role of ungeremine in the growth-inhibiting and cytotoxic effects of lycorine: evidence and speculation. Planta medica. 1988;54(02):114-6
  • Ghosal S, Singh SK, Unnikrishnan SG. Phosphatidylpyrrolophenanthridine alkaloids from Zephyranthes flava. Phytochemistry. 1987;26(3):823-8
  • Ghosal S, Kumar, Y., Singh, SK., and Shanthy, A. The occurrence of N- (3-Hydroxy-4-methoxybenzylidine)-4- hydroxyphenethylamine in Crinum augustum and its biogenetic significance. J Chem Research(s). 1986:28-9.
  • Ghosal S, Kumar, Y., Singh, SK. and Kumar, A. Ungeremine and criasbetaine two anti – tumor alkaloids from Crinum asiaticum. J Chem Research(s). 1986:112-3
  • Ghosal S, Kumar Y, Chakrabarti DK, Lal J, Singh SK. Parasitism of Imperata cylindrica on Pancratium biflorum and the concomitant chemical changes in the host species. Phytochemistry. 1986;25(5):1097-102
  • Ghosal S, Kumar Y, Singh SK, Kumar A. Chemical Constituents of Amaryllidaceae. Part 21. Ungeremine and Criasbetaine, Two Anti‐tumour Alkaloids from Crinum asiaticum. Indian J. of chem​. 1986;17(33):112-113
  • Ghosal S, Kumar Y, Singh SK, Shanthy A. Chemical constituents of amaryllidaceae. XIX: The occurrence of N-(3-hydroxy-4-methoxybenzylidene)-4'-hydroxyphenethylamine in Crinum augustum and its biogenetic significance. J. Chem. Res., Synop. 1986(1):28-9
  • Ghosal S, Singh SK, Srivastava RS. Alkaloids of Zephyranthes flava. Phytochemistry. 1986;25(8):1975-8
  • Ghosal S, Biswas K, Saini K, Singh S. Regioselective Cleavage Of Methylenedioxy Ring In Xanthones: An Entry Into Immuno‐Stimulant 7‐Glucosyloxypolymethoxyxanthones.Indian J. of chem​. 1985;16(21):106-107
  • Ghosal S, Jaiswal DK, Singh SK, Srivastava RS. Dichotosin and dichotosinin, two adaptogenic glucosyloxy flavans from Hoppea dichotoma. Phytochemistry. 1985;24(4):831-3
  • Ghosal S, Singh SK, Srivastava RS. Flavans from Zephyranthes flava. Phytochemistry. 1985;24(1):151-3

Drug Development through Design and synthesis of new chemical entities & isolation of active constituents from Medicinal plants for major diseases/disorders of human by both conventional and advanced techniques

  • Design and synthesis of novel Matrix Metallo Proteinase (MMP-2 & 9) Inhibitors as Therapeutic Agents for Alzheimer’s Disease Funded by DBT, New Delhi( Ongoing-Major:PI)
  • Isolation of marker compounds from natural sources funded by Drug Research & Development Centre, Kolkata( Completed-Minor:PI)
  • Isolation of marker compounds from Withania somnifera funded by Natreon Inc, Kolkata (Completed-Minor:PI)
  • Ethno medicinal plants as a source of new therapeutic agents against psoriasis Funded by NMPB,AYUSH New Delhi(Completed-Major:PI)
  • Cestocidal activity of glands and hairs of fruits of Mallotus phillippinensis (Kampillaka Plant) funded by ICMR, New Delhi(Completed- Major::Co-PI)
  • M Pharm Students: 40 (completed)
  • Ph D Students: 07 (completed); 07 (ongoing)
  • Organizing secretary, Pharmaco-Therapeutics and Formulation Development (PTFD-2005), Varanasi.
  • Joint Secretary and chairman Registration committee, 59th Indian Pharmaceutical Congress held at Varanasi during Dec 2007
  • Organizing Chairman, Emerging Trends in Drug Discovery & Development(ETDDD-2018), Varanasi