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Dr. Shreyans Kumar Jain
Assistant Professor
Department of Pharmaceutical Engg, & Technology
sjain.phe@iitbhu.ac.in
+91-8764331736
Area of Interest: 
Medicinal Chemistry of Natural Products

2016-2018 Postdoctoral, Georgetown University, Washington DC, USA
2015-2016 CSIR-RA, CSIR-Indian Institute of Integrative Medicine, Jammu
2011-2015
 
PhD, CSIR-Indian Institute of Integrative Medicine, Jammu
2010-2011 Project Assistant, CSIR-Indian Institute of Integrative Medicine, Jammu
2007-2010 Research Associate, Piramal Life Science. Mumbai
2005-2007
 
M.S. (Pharm), NIPER—Mohali.  
2001-2004
 
B. Pharmacy, Lachoo Memorial College of Science & Technology- Jodhpur
 

Drug Discovery: Medicinal Chemistry of Natural Products (Isolation, Characterization, Analysis and Synthesis)
Biomarker Discovery: LCMS based Metabolomics and Proteomics

Patents

  1. WO2014167580A1, US20160046611, EP2984078, C2909280, IN 2013DE01077, Vishwakarma, R.A.; Jain, S.K.; Bharate, S.B.; Dar, A.H.; Khajuria, A.; Samdarshi, M.; Bhola, S.K.; Qazi, A.K.; Hussain, A.; Sidiq, T.; Uma Shaanker, R.; Ravikanth, G.; Vasudeva, R.; Patel, M.K.; Ganeshaiah, K.N. New chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders.

 

  1. WO2014170914A1, US20160052915, EP2986605, CA2908084, IN2013DE01142, Vishwakarma, R.A.; Bharate, S.B.; Bhushan, S.; Mondhe Dilip Manikrao; Jain, S.K.; Meena, S.; Guru, S.K.; Pathania, A.S.; Kumar, S. Behl Akanksha, Mintoo Mubashir Javed, Bharate Sonali Sandip and Joshi Prashant Cyclin-dependent kinase inhibition by 5,7-dihydroxy-8-(3-hydroxy-1-methylpiperidin-4-yl)-2-methyl-4H-chromen-4-on analogs.

 

  1. WO2014188440A1, US20160122360, EP3004116, CA2913281, IN2013DE01565, Jain, S.K.; Sidiq, T.; Meena, S.; Khajuria, A.; Vishwakarma, R.A.; Bharate, S.B. Tetrahydro-2H-pyrano{3,2-C]-isochromene-6-ones and analogs for the treatment of inflammatory disorders.

 

  1. IN 201611002826. Bharate SB, Singh S, Singh GD, Jain SK, Kumar A, Singh B, Gupta AP, Anand R, Singh A, Kushwaha M, Gupta M, Sharma G, Sharma A, Vishwakarma RA. Standardized extract of Bergenia ciliata for the treatment of inflammatory disorders 

 

  1. Standardized Extract of Dysoxylum binectariferum for the treatment of inflammatory disorders (File in process)

 

  1. Indolylkojyl derivatives as inhibitor of invasion and metastasis in human mammary gland carcinomas. 2016 (application number 201711022402)

 

Total Publications: 32
     Research: 30
     Book Chapter: 1
     Review: 2
Total Impact: 99.625
 

SN Publication  
  1.  
Singh, R.; Mandrah, K.; Asati, A.; Patel, D. K.; Goel, B.; Vishwakarma, R. A.; Roy, S. K.; Jain, S. K., Transformation of Santonin to a Naproxen Analogue with Anti-Inflammatory Activity. Journal of Natural Product (ACS) 2019, doi.org/10.1021/acs.jnatprod.8b00318. (As corresponding author) 3.885
  1.  
Pannkuk, E. L., E. C. Laiakis, K. Gill, S. K. Jain, K. Y. Mehta, D. Nishita, K. Bujold, J. Bakke, J. Gahagen, S. Authier, P. Chang and A. J. Fornace Jr 2019, Liquid Chromatography – Mass Spectrometry based Metabolomics of Nonhuman Primates after 4 Gy Total Body Radiation Exposure: Global Effects and Targeted Panels." Journal of Proteome Research. (ACS)  DOI: 10.1021/acs.jproteome.9b00101 4.26
  1.  
Derf, A., S. A. Verekar, S. K. Jain, S. K. Deshmukh, S. B. Bharate and B. Chaudhuri (2018). "Radicicol Rescues Yeast Cell Death Triggered by Expression of Human α-Synuclein and its A53T Mutant, but not by Human βA4 Peptide and Proapoptotic Protein Bax." Bioorganic Chemistry doi.org/10.1016/j.bioorg.2018.12.033. 3.92
  1.  
Jain, S.K. Dysoxylum Binectariferum Hook.f., An Indian Medicinal Plant as a Source for Anti-Cancer Agents, In Plants for Human Survival and Medicine, pp 115-149 © 2019, Editor, Bikarma Singh, New India Publishing Agency, New Delhi, India
(BOOK CHAPTER)
NA
  1.  
Shivavedi, N., Jain, S.K., 2017. Review on the discovery of rohitukine-inspired CDK inhibitors. The Pharmstudent 28, 50–58. (IIT-BHU, Internal publication) NA
  1.  
Cheema, A.; Grindrod, S.; Suy, S.; Zhong, X.; Jain, S.; Mehta, K.; Bandi, G.; Kowalczyk, K.; Lynch, J.; Collins, S.; Dritschilo, A., MP35-11 metabolic biomarkers are predictive of response to radiation therapy in prostate cancer patients. The Journal of Urology 2018,199 (4), e451. 5.3
  1.  
K. Unger, K.Y. Mehta, P. Kaur, Y. Wang, S.S. Menon, S.K. Jain, R.A. Moonjelly, S. Suman, K. Datta, R. Singh, P. Fogel, A.K. Cheema, Metabolomics based predictive classifier for early detection of pancreatic ductal adenocarcinoma, Oncotarget, 9 (2018) 23078-23090. 5.1
  1.  
M. Kushwaha, S.K. Jain, N. Sharma, V. Abrol, S. Jaglan, R.A. Vishwakarma, Establishment of LCMS Based Platform for Discovery of Quorum Sensing Inhibitors: Signal Detection in Pseudomonas aeruginosa PAO1, ACS Chem Biol, 13 (2018) 657-665. (Equal Contribution) 4.9
  1.  
S.B. Bharate, V. Kumar, S.K. Jain, M.J. Mintoo, S.K. Guru, V.K. Nuthakki, M. Sharma, S.S. Bharate, S.G. Gandhi, D.M. Mondhe, S. Bhushan, R.A. Vishwakarma, Discovery and Preclinical Development of IIIM-290, an Orally Active Potent Cyclin-Dependent Kinase Inhibitor, Journal of medicinal chemistry, 61 (2018) 1664-1687. (Equal Contribution) 6.2
  1.  
Sharma, N., Kushwaha, M., Arora, D., Jain, S., Singamaneni, V., Sharma, S., Shankar, R., Bhushan, S., Gupta, P., and Jaglan, S. (2018) New Cytochalasin from Rosellinia sanctae-cruciana, an Endophytic Fungus of Albizia lebbeck, J. Appl. Microbiol. 2018 Mar 24. doi: 10.1111/jam.13764 2.09
  1.  
Sharma, R.; Gatchie, L.; Williams, I. S.; Jain, S. K.; Vishwakarma, R. A.; Chaudhuri, B.; Bharate, S. B., Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme. Bioorg. Med. Chem. Lett. 2017,27 (24), 5400-5403. 2.45
  1.  
Qadri, M.; Nalli, Y.; Jain, S. K.; Chaubey, A.; Ali, A.; Strobel, G. A.; Vishwakarma, R. A.; Riyaz-Ul-Hassan, S., An Insight into the Secondary Metabolism of Muscodor yucatanensis: Small-Molecule Epigenetic Modifiers Induce Expression of Secondary Metabolism-Related Genes and Production of New Metabolites in the Endophyte. Microbial ecology 2017,73 (4), 954-965. 3.6
  1.  
Meena, S.; Singh, R.; Vishwakarma, R. A.; Aga, M. A.; Jain, S. K (corresponding author)., SeO2 mediated efficient synthesis of amides and α-ketoamides of secondary amines with wide substrate scope. Tetrahedron Letters 2016,57 (33), 3715-3717. 2.2
  1.  
Kumar, V.; Guru, S. K.; Jain, S. K.; Joshi, P.; Gandhi, S. G.; Bharate, S. B.; Bhushan, S.; Bharate, S. S.; Vishwakarma, R. A., A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties. Bioorganic & Medicinal Chemistry Letters 2016,26 (15), 3457-3463. 2.45
  1.  
Khan, S.; Pandotra, P.; Manzoor, M.; Kushwaha, M.; Sharma, R.; Jain, S.; Ahuja, A.; Amancha, V.; Bhushan, S.; Guru, S.; Gupta, A.; Vishwakarma, R.; Gupta, S.,, Terpenoid and flavonoid spectrum of in vitro cultures of Glycyrrhiza glabra revealed high chemical heterogeneity: platform to understand biosynthesis, Plant Cell, Tissue and Organ Culture (PCTOC), 2016, 124, 3, 507-516 2.0
  1.  
Singh, B.; Jain, S. K.; Bharate, S. B.; Kushwaha, M.; Gupta, A. P.; Vishwakarma, R. A., Simultaneous quantification of five bioactive flavonoids in high altitude plant Actinocarya tibetica by LC-ESI-MS/MS.J. AOAC Int. 2015, 98 (4), 907-12. 0.96
  1.  
Jain, S. K.; Singh, S.; Khajuria, A.; Guru, S. K.; joshi, p.; Meena, S.; Nadkarni, J.; Singh, A.; Bharate, S. S.; Bhushan, S.; Bharate, S. B.; Vishwakarma, R. A., Pyrano-isochromanones as IL-6 inhibitors: Synthesis, in-vitro and in-vivo anti-arthritic activity. J. Med. Chem. 2014, 57, 7085-7097. 5.44
  1.  
Joshi, P.; Singh, S.; Wani, A.; Sharma, S.; Jain, S. K.; Singh, B.; Gupta, B.; Satti, N.; Koul, S.; Khan, I. A.; Kumar, A.; Bharate, S. B.; Vishwakarma, R. A., Osthol and curcumin as inhibitors of human Pgp and multidrug efflux pumps of Staphylococcus aureus: Reversing the resistance against frontline antibacterial drugs. Med. Chem. Commun. 2014, 5, 1540-1547. 2.6
  1.  
Jain, S. K.; Aravinda Kumar, K. A.; Bharate, S. B.; Vishwakarma, R. A., Facile access to amides and hydroxamic acids directly from nitroarenes. Org.  Biomol. Chem. 2014, 12, (33), 6465-6469. 3.56
  1.  
Jain, S. K.; Meena, S.; Gupta, A. P.; Kushwaha, M.; Uma Shaanker, R.; Jaglan, S.; Bharate, S. B.; Vishwakarma, R. A., Dysoxylum binectariferum bark as a new source of anticancer drug camptothecin: Bioactivity-guided isolation and LCMS-based quantification. Bioorg. Med. Chem. Lett. 2014, 24, (14), 3146-3149 2.4
  1.  
Jain, S. K.; Meena, S.; Qazi, A. K.; Hussain, A.; Bhola, S. K.; Kshirsagar, R.; Pari, K.; Khajuria, A.; Hamid, A.; Shaanker, R. U.; Bharate, S. B.; Vishwakarma, R. A., Isolation and biological evaluation of chromone alkaloid dysoline, a new regioisomer of rohitukine from Dysoxylum binectariferum. Tetrahedron Lett. 2013, 54, (52), 7140-7143 2.2
  1.  
Jain, S. K.; Pathania, A. S.; Parshad, R.; Raina, C.; Ali, A.; Gupta, A. P.; Kushwaha, M.; Aravinda, S.; Bhushan, S.; Bharate, S. B.; Vishwakarma, R. A., Chrysomycins A-C, antileukemic naphthocoumarins from Streptomyces sporoverrucosus. RSC Adv. 2013, 3, (43), 21046-21053. 3.7
  1.  
Jain, S. K.; Pathania, A. S.; Meena, S.; Sharma, R.; Sharma, A.; Singh, B.; Gupta, B. D.; Bhushan, S.; Bharate, S. B.; Vishwakarma, R. A., Semisynthesis of Mallotus B from Rottlerin: Evaluation of Cytotoxicity and Apoptosis-Inducing Activity. J. Nat. Prod. 2013,76, (9), 1724-1730 3.9
  1.  
Jain, S. K.; Meena, S.; Singh, B.; Bharate, J. B.; Joshi, P.; Singh, V. P.; Vishwakarma, R. A.; Bharate, S. B., KF/alumina catalyzed regioselective benzylation and benzoylation using solvent-free grind-stone chemistry. RSC Adv. 2012, 2, (24), 8929-8933. 3.7
  1.  
Jain, S. K.; Bharate, S. B.; Vishwakarma, R. A., Cyclin-dependent kinase inhibition by flavoalkaloids. Mini-Rev. Med. Chem. 2012, 12, (7), 632-649. 2.4
  1.  
Singh, B.; Guru, S. K.; Kour, S.; Jain, S. K.; Sharma, R.; Sharma, P. R.; Singh, S. K.; Bhushan, S.; Bharate, S. B.; Vishwakarma, R. A., Synthesis, antiproliferative and apoptosis-inducing activity of thiazolo[5,4-d]pyrimidines. Eur. J. Med. Chem. 2013,70, 864-74. 3.5
  1.  
Mudududdla, R.; Jain, S. K.; Bharate, J. B.; Gupta, A. P.; Singh, B.; Vishwakarma, R. A.; Bharate, S. B., ortho-Amidoalkylation of Phenols via Tandem One-Pot Approach Involving Oxazine Intermediate. J. Org. Chem. 2012, 77, (19), 8821-8827 4.5
  1.  
Bharate, J. B.; Guru, S. K.; Jain, S. K.; Meena, S.; Singh, P. P.; Bhushan, S.; Singh, B.; Bharate, S. B.; Vishwakarma, R. A., Cu-Mn spinel oxide catalyzed synthesis of imidazo[1,2-a]pyridines through domino three-component coupling and 5-exo-dig cyclization in water. RSC Adv. 2013, 3, (43), 20869-20876. 3.7
  1.  
Singh, B.; Sidiq, T.; Joshi, P.; Jain, S. K.; Lawaniya, Y.; Kichlu, S.; Khajuria, A.; Vishwakarma, R. A.; Bharate, S. B., Anti-inflammatory and immunomodulatory flavones from Actinocarya tibetica Benth. Nat. Prod. Res. 2013, 27, (23), 2227-2230. 0.57
  1.  
Bharate, S. B.; Singh, B.; Bharate, J. B.; Jain, S. K.; Meena, S.; Vishwakarma, R. A., QSAR and pharmacophore modeling of N-acetyl-2-aminobenzothiazole class of phosphoinositide-3-kinase-alpha inhibitors. Med. Chem. Res. 2013, 22, 890–899. 1.24
  1.  
Sharma, R.; Guru, S.K.; Jain, S.K.; Pathania, A.S.; Vishwakarma, R.A.; Bhushan, S.; Bharate, S.B. 3-(2,6-Dichloro-benzyloxy)-11-oxo-olean-12-ene-29-oic acid, a semisynthetic derivative of glycyrrhetic acid: Synthesis, antiproliferative, apoptotic and anti-angiogenesis activity. Med. Chem. Comm.2014, DOI: 10.1039/C4MD00344F 2.5
  1.  
Mishra, P. D.; Verekar, S.; Kulkarni, A. A.; Roy, S. K.; Jain, S.; Balakrishnan, A.; Vishwakarma, R. A.; Deshmukh, S., Anti-inflammatory and anti-diabetic naphthoquinones from an endophytic fungus Dendryphion nanum (Nees) S.Hughes. Indian J. Chem. Sec. B 2013,52B, 565-567. 0.9
  1.  
Singh, I. P.; Jain, S. K.; Kaur, A.; Singh, S.; Kumar, R.; Garg, P.; Sharma, S. S.; Arora, S. K., Synthesis and antileishmanial activity of piperoyl-amino acid conjugates. Eur J Med Chem 2010,45 (8), 3439-45. 3.5
  1. Postdoctoral Fellowship at Waters Innovation Center for Metabolomics
  2. Award for outstanding contribution to compound library on CSIR Foundation day Sep 26, 2015
  3. Best Research Paper award on CSIR Foundation day Sep 26, 2015
  4. Best Patent award on CSIR Foundation day Sept 26, 2014
  5. Award CSIR Research Associateship 2014-2015
  6. Award CSIR SRF 2012
  7. Qualified NIPER entrance for admission in MS (Pharm).
  8. Qualified GATE 2003AIR -108 (97.94 pecentile).
  9. Qualified GATE 2003-2004: AIR -102 (98.94 pecentile).