ksairam.phe's picture
Dr. Sairam Krishnamurthy
Professor
Department of Pharmaceutical Engineering and Technology IIT BHU
ksairam.phe@iitbhu.ac.in
9935509199
Area of Interest: 
Pharmacology, Neuroscience and Mitochondrial medicine.

EDUCATION

1986-1990         B.Pharm., University of Madras, India

1992-1994         M.Pharm., TN MGR Medical University, India
1998-2001         Ph.D. in Pharmacology, Institute of Medical Sciences, Banaras Hindu University, India

 2002- 2005       Postdoctoral Scholar, College of Pharmacy, University of Kentucky, Lexington, KY. U.S.A.
  2005                Postdoctoral Fellow, Spinal cord and Brain Injury Research Center (SCoBIRC), University of Kentucky Chandler Medical Center, Lexington, U.S.A.
PROFESSIONAL APPOINTMENTS
1990-1992        Asst. Manufacturing Chemist, Ranka Pharmaceuticals (P) Ltd., India
1994-1998        Asst.Prof, Department of Pharmacology, SRM University, College of Pharmacy, India
2006                Scientist-I, Spinal cord and Brain Injury Research Center (SCoBIRC), University of  Kentucky Chandler Medical Center, Lexington, KY. U.S.A.
2006-2009        Reader in Pharmacology, Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221005, India.
2009-2018        Associate Professor, Department of Pharmaceutics, Indian Institute of Technology, (Banaras Hindu University), Varanasi-221005,India.        
2018-Present     Professor, Department of Pharmaceutical Engg &Tech, Indian Institute of Technology, (Banaras Hindu University), Varanasi-221005, India                                                      

 

  1. Prajapati SK, Dangi DS, Krishnamurthy S (2019)Repeated caffeine administration aggravates post-traumatic stress disorder-like symptoms in rats. Physiology & Behavior, (IF-2.635)
  2. S. Hossain SK, Yadav S, MajumdarS , Krishnamurthy S, Pyare R, Roy P.K. (2019) A comparative study of physico-mechanical, bioactivity and hemolysis properties of pseudo-wollastonite and wollastonite glass-ceramic synthesized from solid wastes. Ceramics International (IF-3.450)
  3. Gupta S K, Patel SK, Tomar MS, Singh SK, Mesharam MK and Krishnamurthy S (2019)  Long-term exposure of 2450 MHz Electromagnetic radiation induces stress and anxiety like behavior in rats, Neurochemistry International (IF-3.603)
  4. Mishra A, Krishnamurthy S (2019) Rebamipide Mitigates Impairments in Mitochondrial Function and Bioenergetics with α- Synuclein Pathology in 6-OHDA-Induced Hemiparkinson’s Model in Rats, Neurotoxicity research, 1-21. (IF-2.945)
  5. Gopichand Gutti, Devendra Kumar, Pankaj Paliwal, Ankit Ganeshpurkar, Khemraj Lahre, Ashok Kumar, Sairam Krishnamurthy, Sushil Kumar Singh (2019)  Development of pyrazole and spiropyrazoline analogs as multifunctional agents for treatment of Alzheimer’s disease Bioorganic Chemistry, 103080 (IF-3.929)
  6. Gaurav Kumar, Sumedha Mukherjee, Pankaj Paliwal, Saumitra Sen Singh, Hareram Birla, Surya Pratap Singh, Sairam Krishnamurthy, Ranjana Patnaik Neuroprotective effect of chlorogenic acid in global cerebral ischemia-reperfusion rat model Naunyn-Schmiedeberg's archives of pharmacology, 1-17.
  7. Puja Mishra, Piyoosh Sharma, Prabhash Nath Tripathi, Sukesh Kumar Gupta, Pavan Srivastava, Ankit Seth, Avanish Tripathi, Sairam Krishnamurthy, Sushant Kumar Shrivastava (2019) Design and Development of 1, 3, 4-Oxadiazole Derivatives as Potential Inhibitors of Acetylcholinesterase to Ameliorate Scopolamine-Induced Cognitive Dysfunctions. Bioorganic Chemistry, 103025. (IF-3.929)
  8. Arepalli S K, Tripathi H, Manna PP, Pankaj P, Krishnamurthy S, Shashikant CU Patne, Pyare R, Singh SP (2019) Preparation and in vitro investigation on bioactivity of magnesia-contained bioactive glasses. Journal of the Australian Ceramic Society, 55 (1), 145-155 (IF:0.744)
  9. Arepalli S K, Tripathi H, Manna PP, Pankaj P, Krishnamurthy S, Shashikant CU Patne, Pyare R, Singh SP (2018)  Enhanced in vivo biocompatibility of magnesia-contained bioactive glasses Journal of the Australian Ceramic Society, 55 (2), 337-342 (IF:0.744)
  10. Gaurav Kumar, Pankaj Paliwal, Sumedha Mukherjee, Nishant Patnaik, Sairam Krishnamurthy, Ranjana Patnaik (2019) Pharmacokinetics and Brain Penetration Study of Chlorogenic Acid. Xenobiotica, 49 (3), 339-345. (IF:1.932)
  11. Devendra Kumar, Sukesh K Gupta, Ankit Ganeshpurkar, Ravi Singh, Dileep Kumar, Nitul Das, Sairam Krishnamurthy, Sushil Kumar Singh (2019) Biological profiling of piperazinediones for the management of anxiety. Pharmacology Biochemistry and Behavior 176, 63-71 (IF:2.748)
  12. Piyoosh Sharma, Avanish Tripathi, Prabhash Nath Tripathi, Santosh Kumar Prajapati, Ankit Seth, Manish Kumar Tripathi, Pavan Srivastava, Vinod Tiwari, Sairam Krishnamurthy, Sushant Kumar Shrivastava (2019) Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry (IF:4.519).
  13. Akanksha Mishra, Lalit Pratap Chandravanshi, Surendra Kumar Trigun and Sairam Krishnamurthy (2018) Ambroxol modulates 6-Hydroxydopamine-induced temporal reduction in Glucocerebrosidase (GCase) enzymatic activity and Parkinson’s disease symptoms. Biochemical Pharmacology. 155, 479-493 (IF:4.235)
  14. Arun Kumar Mahanta, Sudipta Senapati, Pralay Maiti, Pankaj Paliwal, Sairam Krishnamurthy, Siva Hemalatha (2018) Nanoparticle Induced Controlled Drug Delivery using Chitosan based Hydrogel and Scaffold: Application to Bone Regeneration. Molecular pharmaceutics 16 (1), 327-338 (IF:4.556)
  15. Bhupinder Kumar, Ashish Ranjan Dwivedi, Bibekananda Sarkar, Sukesh Kumar Gupta, Sairam Krishnamurthy, Anil K Mantha, Jyoti Prakash, and Vinod Kumar (2018) 4, 6-Diphenylpyrimidine Derivatives as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease. ACS Chem. Neurosci., DOI: 10.1021/acschemneuro.8b00220 • Publication Date (Web): 08 Oct 2018(IF-4.211)
  16. Pandey A, Joshi A, Mishra S, Krishnamurthy S, Hemalatha S (2018) Antinociceptive, anti inflammatory and antiarthritic activity of ethanol root extract and fraction of Aganosma dichotoma (Roth) K. Schum. Indian J Exp Biol. Vol.56(09) [September 2018]. http://nopr.niscair.res.in/handle/123456789/44999.(IF-1.475).
  17. Paliwal P, Kumar AS, Tripathi H, Singh SP, Patne SCU, Krishnamurthy S (2018) Pharmacological application of barium containing bioactive glass in gastro-duodenal ulcers. Materials Science and Engineering: C.  92, 424-434 (IF:5.100)
  18. Reddy NR, Krishnamurthy S (2018) Repeated olanzapine treatment mitigates PTSD like symptoms in rats with changes in cell signaling factors. Brain research bulletin. (IF:3.033)
  19. Hussain Y, Krishnamurthy S     (2018)  Piracetam attenuates binge eating disorder related symptoms in rats. Pharmacol Biochem Behav. 169, 35-47. (IF:2.748)
  20. Paliwal P, Chauhan G, Gautam D, Dash D, Patne SCU, Krishnamurthy S (2018) Indole-3-carbinol improves neurobehavioral symptoms in a cerebral ischemic stroke model Naunyn-Schmiedeberg's archives of pharmacology, 391 (6), 1-13. (IF:2.558)
  21. Gupta SK, Krishnamurthy S  (2018) Electromagnetic radiation 2450 MHz exposure causes cognition deficit with mitochondrial dysfunction and activation of intrinsic pathway of apoptosis in rats. Journal of biosciences. (IF:1.422)
  22. Devendra Kumar, Sukesh K Gupta, Ankit Ganeshpurkar, Gopichand Gutti, Sairam Krishnamurthy, Gyan Modi, Sushil Kumar Singh (2018) Development of Piperazinediones as dual inhibitor for treatment of Alzheimer's disease. European Journal of Medicinal Chemistry 150, 87-101 (IF:4.519)
  23. Samaiya PK, Narayan G, Kumar A, Krishnamurthy S (2018) 2, 4 dinitrophenol attenuates mitochondrial dysfunction and improves neurobehavioral outcomes post-anoxia in neonatal rats. Neurotoxicity Research 1-16 (DOI: 10.1007/s12640-018-9873-7) (IF-2.945)
  24. Tripathi RKP, Sasi V M, Gupta SK, Krishnamurthy S, Ayyannan SR (2018). Design, synthesis, and pharmacological evaluation of 2-amino-5-nitrothiazole derived semicarbazones as dual inhibitors of monoamine oxidase and cholinesterase: effect of the size of aryl binding site. Journal of Enzyme Inhibition and Medicinal Chemistry 33 (1), 37-57. (IF-4.293)
  25. Paliwal P, Dash D, Krishnamurthy S (2018) Pharmacokinetic study of Piracetam in Focal Cerebral Ischemic rats. European Journal of Drug metabolism and pharmacokinetics  43 (2), 205-213. (IF-1.400)
  26. Sharma P, Kumari A, Gulati A, Krishnamurthy S, Hemalatha S (2017) Chrysin isolated from Pyrus pashia fruit ameliorates convulsions in experimental animals. Nutritional Neuroscience, 1-9. (IF-3.765)
  27. Kumar S, Mishra A, Krishnamurthy S (2017) Purinergic Antagonism Prevents Mitochondrial Dysfunction and Behavioral Deficits Associated with Dopaminergic Toxicity Induced by 6-OHDA in Rats. Neurochemical Research,  42 (12),1-17.(IF-2.581)
  28. Tripathi A, Paliwal P, Krishnamurthy S (2017) Piracetam Attenuates LPS-Induced Neuroinflammation and Cognitive Impairment in Rats. Cellular and Molecular Neurobiology, 37 (8),1-14. (IF-2.506)
  29. Prajapati SK, Garabadu D, Krishnamurthy S (2017)  Coenzyme Q10 Prevents Mitochondrial Dysfunction and Facilitates Pharmacological Activity of Atorvastatin in 6-OHDA Induced Dopaminergic Toxicity in Rats. Neurotoxicity Research, 31 (4),1-15 (IF-2.945)
  30. Samaiya PK, Narayan G, Kumar A, Krishnamurthy S (2017) Tempol (4 hydroxy-tempo) inhibits anoxia-induced progression of mitochondrial dysfunction and associated neurobehavioral impairment in neonatal rats. Journal of the Neurological Sciences, 375, 58-67.(IF-2.295)
  31. Garabadu D, Krishnamurthy S (2017) Metformin attenuates hepatic insulin resistance in type-2 diabetic rats through PI3K/Akt/GLUT-4 signalling independent to bicuculline-sensitive GABAA receptor stimulation. Pharmaceutical Biology 55 (1), 722-728. (IF-1.916)
  32. Kushwah S, Kumar A, Basu S, Krishnamurthy S, Kumar A (2017) Comparison of cerebrospinal fluid Cytochrome-c and Caspase-9 as biomarkers for newborns with hypoxic ischemic encephalopathy with non-asphyxiated babies and follow up of these biomarkers after day 7. International Journal of Research in Medical Sciences 3 (8), 2034-2040.
  33. Samaiya PK, Narayan G, Kumar A, Krishnamurthy S (2016) Neonatal anoxia leads to time dependent progression of mitochondrial linked apoptosis in rat cortex and associated long term sensorimotor deficits.  International Journal of Developmental Neuroscience. Aug;52:55-65. (IF-2.046)
  34. Rati K. P. Tripathi, Sairam Krishnamurthy, and Senthil Raja Ayyannan (2016) Discovery of 3-Hydroxy-3-phenacyloxindole Analogues of Isatin as Potential Inhibitors of Monoamine Oxidase. ChemMedChem. 11 (1), 119-132 (IF:2.968)
  35. Garabadu D, Shah A, Singh S, Krishnamurthy S (2015) Protective effect of eugenol against restraint stress-induced gastrointestinal dysfunction: Potential use in irritable bowel syndrome. Pharmaceutical biology 53 (7), 968-974(IF-1.916)
  36. Garabadu D, Ahmad A, Sairam Krishnamurthy (2015) Risperidone Attenuates Modified Stress–Re-stress Paradigm-Induced Mitochondrial Dysfunction and Apoptosis in Rats Exhibiting Post-traumatic Stress Disorder-Like Symptoms. Journal of Molecular Neuroscience, 56 (2), 1-14.(IF-2.757)
  37. Samaiya PK, Sairam Krishnamurthy (2015) Characterization of mitochondrial bioenergetics in neonatal anoxic model of rats. Journal of bioenergetics and biomembranes, 47 (3),1-6.(IF-3.312)
  38. D Garabadu, BCMH Reddy, S Krishnamurthy, (2015), Citalopram Protects Against Cold-Restraint Stress-Induced Activation of Brain-Derived Neurotrophic Factor and Expression of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells in Rats Journal of Molecular Neuroscience, 55 (2), 355-366 .(IF-2.757)
  39. Milind Geed, DebapriyaGarabadu,  Ausaf Ahmad and Sairam Krishnamurthy (2014) Silibinin pretreatment attenuates biochemical and behavioral changes induced by intrastriatal MPP+ injection in rats. Pharmacol. Biochem. Behav. 117,  92–103.(IF-2.820)
  40. Garabadu D, Sairam Krishnamurthy (2014)  Asparagus racemosus attenuates Anxiety-Like Behavior in Experimental Animal Models. Cellular and molecular neurobiology 34 (4), 511-521.(IF-2.506)
  41. Das N, Garabadu D, Banerjee AG, Sairam Krishnamurthy, Shrivastava SK. (2014) Synthesis and pharmacological evaluation of some N3-aryl/heteroaryl-substituted 2-(2-chlorostyryl)-6, 7-dimethoxy-quinazolin-4 (3H)-ones as potential anticonvulsant agents. Medicinal Chemistry Research, 1-10.(IF-1.402)
  42. Garabadu D, Shah A, Singh S, Sairam Krishnamurthy. (2014) Protective effect of eugenol against restraint stress-induced gastrointestinal dysfunction: Potential use in irritable bowel syndrome, Pharmaceutical Biology, 1-7. (IF-1.337)
  43. Joshi R, Garabadu D, Teja GR, Sairam Krishnamurthy. (2014) Silibinin ameliorates LPS-induced memory deficits in experimental animals. Neurobiology of learning and memory, Dec;116:117-31.3. (IF-3.652)
  44. D Laloo, SK Prasad, Sairam Krishnamurthy, S Hemalatha. (2014) Gastroprotective activity of polyphenolic-rich extract of Potentillamooniana, Pharmaceutical Biology 52 (12), 1532-1542 (IF-1.337)
  45. D Garabadu, Sairam Krishnamurthy. (2014) Diazepam Potentiates the Antidiabetic, Antistress and Anxiolytic Activities of Metformin in Type-2 Diabetes Mellitus with Cooccurring Stress in Experimental Animals, BioMed Research International.(IF-2.706)
  46. Nandi MK, Garabadu D, Sairam Krishnamurthy, TD Singh, VP Singh., (2014) Argyreiaspeciosa attenuates streptozotocine-nicotinamide-induced hyperglycemia in experimental animals of type-2 diabetes mellitus..Der Pharma Chemica 6 (5)
  47. Kumar M, Prasad SK, Sairam Krishnamurthy, Hemalatha S., (2014)  Antihyperglycemic Activity of HouttuyniacordataThunb. inStreptozotocin-Induced Diabetic Rats. Advances in pharmacological sciences.
  48. Sahu Alakh N, Hemalatha S, Sairam K. (2014) Phyto-pharmacological review of mesuaferrea linn. International Journal of Phytopharmacology, 5(1), 6-14.
  49. VPS Manmath K. Nandi, Debapriya Garabadu, Sairam Krishnamurthy, Trayambak D (2014) Methanolic fruit extract of Sesbania grandiflora exhibits anti-hyperglycemic activity in experimental type-2 diabetes mellitus model. Annals of Biological Research 5 (9), 50-58
  50. Sairam Krishnamurthy, Garabadu D and Joy KP. (2013) Risperidone ameliorates post traumatic stress disorder-like symptoms in modified stress re-stress model.Neuropharmacology, 75, 62–77.(IF-4.819)
  51. Damiki Laloo,  Satyendra K. Prasad, Sairam Krishnamurthy, Siva Hemalatha (2013) Gastroprotective activity of ethanolic root extract of Potentillafulgens Wall. ex Hook J Ethnopharmacology, 146 (2),505–514.(IF-2.939)
  52. Sahu Alakh N, Hemalatha S and Sairam Krishnamurthy. (2013) Quality control studies of Argyreiaspeciosa sweet leaves. Int. J. Res. Ayurveda Pharm. 4(4), July-Aug, 495-498.
  53.  SahuAlakh N, Hemalatha S and Sairam Krishnamurthy. (2013) HPTLC fingerprinting and in vitro antioxidant studies of Argyreiaspeciosa sweet leaves and mesuaferrealinn. flowers. Int. J. Res. Ayurveda Pharm. 4(4), July-Aug, 499-502.
  54. SahuAlakh N, Hemalatha S and Sairam K. (2013). Quality Control Studies of MesuaferreaLinn. Flowers. International Journal of Herbal Medicine. 1(2), 124-130.
  55. SahuAlakh N, Hemalatha S, Sairam K. (2013) Gastric-ulcer protective activity of argyreiaspeciosasweet leaves)  International Journal of Biological & Pharmaceutical Research. 2013; 4(12): 1182-1186.
  56. SahuAlakh N, Hemalatha S, Sairam K. (2013) Quantitative Phytochemical and Heavy Metal Estimation of MesuaferreaFlowers and ArgyreiaspeciosaLeaves  Int. J. Pharm. Sci. Rev. Res., 22(2), Sep – Oct 2013( 49), 276-278.
  57.  Patel DK, R Kumar, Sairam Krishnamurthy, Hemalatha S (2013)
    Hybanthusenneaspermus(L.) F. Muell: a concise report on its phytopharmacological aspects. Chinese journal of natural medicines 11 (3), 199-206.(IF-1.114)
  58. Sairam Krishnamurthy, D Garabadu, NR Reddy (2013) Asparagus racemosus modulates the hypothalamic-pituitary-adrenal axis and brain monoaminergic systems in rats. Nutritional neuroscience. 16(6), 255-61.(IF-2.114)
  59. DamikiLaloo,  Satyendra K. Prasad, Sairam Krishnamurthy, Siva Hemalatha(2013) Gastroprotective activity of ethanolic root extract of Potentillafulgens Wall. ex Hook J Ethnopharmacology, 146 (2),505–514.(IF-2.939)
  60. Sairam Krishnamurthy, Garabadu D and Joy KP. (2013) Risperidone ameliorates post traumatic stress disorder-like symptoms in modified stress re-stress model.Neuropharmacology, 75, 62–77.(IF-4.819)
  61. PatelDK  Kumar R..Sairam K.Hemalatha S (2013) Advances in Plant Pharmacology of Hemiphyllum. Chinese Natural Medicine 03,004.
  62. Patel DK, Krishnamurthy S, Hemalatha S (2013) Evaluation of glucose utilization capacity of bioactivity guided fractions of Hybanthus enneaspermus and Pedalium murex in isolated rat hemidiaphragm. Journal of Acute Disease 2 (1), 33-36
  63. Patel D. K., Kumar R., Sairam Krishnamurthy., S. Hemalatha.  (2012) Aphrodisiac activity of ethanolic extract of Pedalium murex Linn fruit. Asian Pacific Journal of Tropical Biomedicine, (2012) Asian Pacific Journal of Tropical Biomedicine, S1568-S1571.
  64. Patel D. K., Kumar R., Kumar M., Sairam Krishnamurthy, Hemalatha S.  (2012) Evaluation of aldose reductase inhibitory potential of different fraction of Hybanthusenneaspermuslinn f. muell. Asian Pacific Journal of Tropical Biomedicine, 2(2): 134-139.
  65. Kumar R, Patel DK, Prasad SK Sairam Krishnamurthy,Hemalatha S. (2012) Antidiabetic activity of alcoholic root extract of Caesalpiniadigynain streptozotocin-nicotinamide induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine S934-S940.
  66. Patel DK, Kumar R, Sairam KrishnamurthyHemalatha, S (2012)
    Pharmacologically tested aldose reductase inhibitors isolated from plant sources—A concise report.Chinese Journal of Natural Medicines 10 (5), 388-400. (IF-1.114/2014)
  67. Patel DK, Sairam Krishnamurthy, S Hemalatha(2012)
    Evaluation of glucose utilization capacity of bioactivity guided fractions of Hybanthusenneaspermus and Pedalium murex  in isolated rat hemidiaphragm. Journal of Acute Disease 2 (1), 33-36.
  68. D Laloo, M Kumar, SK Prasad, K Sairam, S Hemalatha (2012) Gastroprotective activity of the alcoholic root extract of Potentilla fulgens wall. Reviews on clinical pharmacology and medicinal therapy.(10) 2.
  69. Bithu BS, Reddy NR, Prasad SK, Sairam Krishnamurthy, Hemalatha S (2012) Prosopis cineraria: A potential nootropic agent. Pharmaceutical Biology 50 (10), 1241-1247.(IF-1.206)
  70. Surapaneni DK, Adapa SR, Preeti K, Teja GR, Veeraragavan M, Sairam Krishnamurthy. (2012)  Shilajit attenuates behavioral symptoms of chronic fatigue syndrome by modulating the hypothalamic-pituitary-adrenal axis and mitochondrial bioenergetics in rats. J Ethnopharmacol, Aug 30;143(1):91-9.(IF-2.755)
  71. DebapriyaGarabadu, Ankit Shah, Ausaf Ahmad, Vijaya Joshi, BhagawathiSaxena, GautamPalit, Sairam Krishnamurthy.(2011) Eugenol as an Anti-Stress Agent: Modulation of Hypothalamic-Pituitary-Adrenal Axis Activity and Brain Monoaminergic systems. Stress. Mar;14(2):145-55.(IF-2.553)
  72. Saxena B Sairam Krishnamurthy, Singh S. (2011) Gastroprotective potential of risperidone, an atypical antipsychotic, against stress and pyloric ligation induced gastric lesions.ChemBiol Interact. Apr 25;190(2-3):155-64. (IF-2.865)
  73. Reddy NR, Sairam Krishnamurthy, Chourasia TK, Kumar A, Joy KP. (2011) Glutamate antagonism fails to reverse mitochondrial dysfunction in late phase of experimental neonatal asphyxia in rats.Neurochem Int. Apr;58(5):582-90. (IF-3.601)
  74. Sairam Krishnamurthy, GarabaduD, Reddy R and Joy KP. (2011) Risperidone in ultra low dose protects against stress in the rodent cold restraint model by modulating stress pathways.   Neurochem. Res.  36 (10) 1750-1758.(IF-2.608)
  75. Meena J,Ojha R, Muruganandam  AV and Sairam Krishnamurthy. (2011) Asparagus racemosus competitively inhibits in vitro the acetylcholine and monoamine metabolizing enzymes. Neurosci.Lett.  503(1),  6-9.(IF-2.055)
  76. Patel DK, Kumar R, Prasad SK, Sairam Krishnamurthy, Hemalatha S. (2011) Antidiabetic and in vitro antioxidant potential of Hybanthusenneaspermuslinn f. muell in streptozotocin-induced-diabetic rats. Asian Pacific Journal of Tropical Biomedicine 316-322.
  77. Kumar R. Patel, D. K,.Laloo D, Sairam Krishnamurthy, Hemalatha S. (2011) Inhibitory effect of two Indian medicinal plants on aldose reductase of rat lens an in vitro study. Asian Pacific Journal of Tropical Medicine, 4, ( 9), September, Pages 694-697.
  78. Patel D. K., Prasad S. K, Sairam Krishnamurthy, Hemalatha., S. (2011) Aldose reductase inhibitory principles from the whole plant of Hybanthusenneaspermus (Linn) F. Muell. Asian Pacific Journal of Tropical Disease , 2 (1),S-165-S169.(IF-1.062/2014)
  79. Patel D.K., Kumar R, Sairam Krishnamurthy., Hemalatha S. (2011) Aldose reductase inhibitory activity of alcoholic extract of Pedalium murex Linn. Asian Pac J Trop Biomed, 2, (1), Supplement, January, S265–S269.
  80. Rajesh Kumar, Dinesh K. Patel, Satyendra K. Prasad, DamikiLaloo, Sairam Krishnamurthy, Hemalatha S. (2011) Type 2 antidiabetic activity of bergenin from the roots of CaesalpiniadigynaRottler.Fitoterapia 83 (2),395-401.(IF-2.231)
  81.  Rajesh Kumar, Dinesh Kumar Patel, SatyendraKuldip Prasad, Sairam Krishnamurthy, Siva Hemalatha. (2011) Antidiabetic activity of alcoholic leaves extract of AlangiumlamarckiiThwaites on streptozotocin–nicotinamide induced type 2 diabetic rats. Asian Pacific Journal of Tropical Medicine 4 (11), 904–909.(IF-1.062/2014)
  82. Nickell JR, Sairam Krishnamurthy, Norrholm S, Deaciuc G, Siripurapu KB, Zheng G, Crooks PA, Dwoskin LP.(2010) Lobelane Inhibits Methamphetamine-Evoked Dopamine Release via Inhibition of the Vesicular Monoamine Transporter-2.J PharmacolExpTher.Feb;332(2):612-21. (IF-4.017)
  83. Ohja R, Sahu AN, Muruganandam AV, Singh GK, Sairam rishnamurthy.(2010)Asparagus recemosus enhances memory and protects against amnesia in rodent models. Brain and Cognition.  Oct;74(1):1-9. (IF-2.838)
  84. SahuAlakh N, Hemalatha S, Sairam Krishnamurthy, Laloo D.and Patra A.  (2010) Quality Control Studies of Ochrocarpuslongifolius Flower Buds.   PHCOG J February ;Pharmacognosy Journal2 (6) ,118-123.
  85. Sahu A N, Hemalatha S, Sairam Krishnamurthy. (2010) Phytochemical quantitative estimation and pesticide residue determination of Mesua ferreaflowers. Journal of Medicinal and Aromatic Plant Sciences 32 (4)  187-192.
  86. Rao Ch.V, Vijayakumar M, Krishnamurthy S, Vikas Kumar (2008) Antidiarrhoeal activity of the standardised extract of Cinnamomum tamala in experimental rats. J Nat Med(Tokyo) 2008 Oct;62(4):396-402. (0.424/2007)
  87. Gireesh KS, Debapriya G, Muruganadam AV, Joshi VK, Krishnamurthy S (2009). Antidepressant activity of Asparagus racemosus in animal models of depression. Pharmacol. Biochem. Behav. 2009 Jan;91(3):283-90 (2.35/2007)
  88. Sajeli Begum A., Bhagawati Saxena, Madhur Goyal, Rakesh Ranjan, Vijaya B. Joshi, Ch V. Rao, Krishnamurthy S, Mahendra Sahai. Study of anti-inflammatory, analgesic and antipyretic activities of seeds of Hyoscyamus niger and isolation of a new coumarinolignan. Fitoterapia 2009 Apr;81(3):178-84. (1.2/2008)
  89. Sullivan P, Krishnamurthy S, Pandya J, Rabchevsky AG (2007) Temporal characterization of mitochondrial bioenergetics and effect of mitochondrial targeted compounds in spinal cord injury. J. Neurotrauma 24:991-999. (3.640/2007)
  90. Goel R K, Sairam K, Dorababu M, Prabha T and Rao  Ch V (2005) Effect of standardized extract of Ocimum sanctum Linn. on gastric mucosal offensive and defensive factors. Indian J Exp Biol 43:715-721.
  91. Sairam K, Hemalatha S, Kumar A, Srinivasan T, Ganesh J, Shankar M and Venkataraman S (2003) Evaluation of anti-diarrhoeal activity in seed extracts of Mangifera indica. J Ethnopharmacol 84:11-15. (1.269/2003)
  92. Sairam K, Priyambada S, Aryya NC and Goel RK (2003)  Anti-gastroduodenal ulcerogenic activity of Asparagus racemosus- an experimental, biochemical and histological study. J Ethnopharmacol 86:1-10. (1.269/2003)
  93. Goel RK, Sairam K, Travares IA and Raman A (2003) In vitro evaluation of Bacopa monniera on accumulation of prostaglandins and anti-Helicobacter pylori activity. Phytomedicine10:523-527. (1.138/2003)
  94. Sairam K, Saravanan KS, Banerjee R and Mohanakumar KP (2003) Non-steroidal anti-inflammatory drug sodium salicylate, but not diclofenac or celecoxib, protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats. Brain Res 966:245-252.(2.474/2003)
  95. Bhattacharya SK, Bhattacharya A, Sairam K and Ghosal S (2002) Effect of bioactive tannoid principles of Emblica officinalis on ischemia-reperfusion induced oxidative stress on rat heart. Phytomedicine 9:171-174. (0.935/2002)
  96. Bhattacharya SK, Bhattacharya D, Sairam K and Ghosal S (2002) Effect of Withania somnifera glycowithanolides on rat model of tardive dyskinesia. Phytomedicine 9:167-170. (0.935/2002)
  97. Sairam K, Dorababu M , Goel RK and  Bhattacharya SK (2002) Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats. Phytomedicine 9:207-211. (0.935/2002)
  98. Sairam K, Rao Ch.V, Dora Babu M, Agrawal VK and Goel RK (2002) Antiulcerogenic effect of methanolic extract of Emblica officinalis: an experimental study. J Ethnopharmacol 82:1-9. (1.269/2003)
  99. Datla GK, Sairam K, Priyambada S, Debnath PK and Goel RK (2002)  Antiulcerogenic activity of Satavari mandur-an Ayurvedic herbo-mineral preparation. Indian J Exp Biol40:1173-1177.
  100. Rao Ch V, Sairam K and Goel RK (2001) Experimental evaluation of Emblica officinalis fruit on gastric ulcers and mucosal offensive and defensive factors in rats. Acta Pharmaceutica Turcica XLIII: 155-160.(0/2001)
  101. Sairam K, Rao CH V, Dora Babu M and Goel RK (2001) Prophylactic and curative effects of Bacopa monniera in gastric ulcer models. Phytomedicine 8:423-430. (0.935/2002)
  102. Sairam K, Rao Ch V and Goel RK (2001) Effect of Convolvulus pluricaulis Chois on gastric ulceration and secretion in rats. Indian J Exp Biol 39:350-354.
  103. Bhattacharya SK, Bhattacharya A, Das K, Muruganantham AV and Sairam K (2001) Further investigations on the antioxidant activity of Ocimum sanctum using different paradigms of oxidative stress in rats. Natural Remedies 1:1-13.
  104. Sairam K, Rao Ch V and Goel RK (2001) Effect of Centella asiatica Linn on physical and chemical factors induced gastric ulceration and secretion in rats. Indian J Exp Biol 39:137-142.
  105. Goel RK, Sairam K, Rao Ch V and Raman A (2001) Role of gastric antioxidant and anti-H.pylori activities in the antiulcerogenic activity of plantain banana (Musa sapientum Linn var. paradisiaca). Indian J Exp Biol 39:719-722.
  106. Bhattacharya SK, Bhattacharya A, Sairam K and Ghosal S (2000) Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Phytomedicine 7:463-469.(0.779/2000)
  107. Rao Ch. V, Sairam K and Goel RK (2000) Experimental evaluation of Bacopa monniera on rat gastric ulceration and secretion. Indian J Physiol Pharmacol 44: 435-441.
  108. Agrawal AK, Rao Ch.V, Sairam K, Joshi VK and Goel RK (2000) Effect of Piper longum Linn, Zingiber officianalis Linn and Ferula species on gastric ulceration and secretion in rats. Indian J Exp Biol 38:994-998.
  109. Sairam K, Rao Ch V and Goel RK (2000) Effect of Ocimum sanctum Linn on peptic ulcers and gastric mucosal offensive and defensive factors. Biomedicine 20:260-267

Review

  1. Goel RK and Sairam Krishnamurthy (2001) Antiulcer drugs from indigenous sources with emphasis on Musa sapientum, tamrabasma, Asparagus racemosus and Zingiber officinale. Indian J Pharmacol 34:100-110. 
  • Project Title: Evaluation of anti-depressant activity of Asparagus racemosus,
            Principal Investigator: Sairam Krishnamurthy
             Sponsor: Seed grant, Banaras Hindu University.2007
  • Project Title: “Phytochemical Standardization and Pharmacological Evaluation of Some Potential Anti-Gastroduodenal Ulcer Plants”.
             Principal Investigator: Dr. A.N. Sahu, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University).

            Co- Principal Investigator: Sairam Krishnamurthy
             Sponsor: AICTE (Govt. of India) , 2007-2009.

  • Project Title: “Pharmacological Evaluation of Atypical Anti-psychotics for Anti-Post Traumatic Stress Disorder Activity in Rodent Models”.

        Principal Investigator: Sairam Krishnamurthy
         Co- Principal Investigator: Prof.K.P.Joy, Department of Zoology, Banaras Hindu University.
        Sponsor: CSIR (Govt. of India), 2009-2012..

  • Project Title “Experimental and clinical basis of novel treatment strategy using mitochondrial modulators in neonatal anoxic injury”.

       Principal Investigator: Sairam Krishnamurthy
      Co-Principal Investigators: Prof. Ashok Kumar, Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, and Prof. Gopeshwar Narayan,  Department of Molecular and Human Genetics, Banaras Hindu University, Varanasi 221005, India.
       Sponsor: DBT (Govt. of India); 2012-16.

  • Project Title: “Design, Synthesis and in vitro Anticancer Evaluation of Some Novel Curcumin Analogs;

         Principal Investigator: Sairam Krishnamurthy
          Co- Principal Investigator: Dr.Senthil Raja A , Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology      (Banaras Hindu University)
         Sponsor : M/S Disto Pharmaceuticals Pvt. Ltd. India; 2012

  • Project Title: “Chemical and pharmacological characterization of Shatavarin IV from Asparagus racemosus and its semi-synthetic analogues for antidepressant activity”;

           Principal Investigator: Sairam Krishnamurthy
          Co- Principal Investigators: Prof.R.S. Srivastava, Prof. S.Hemalatha, Dr.Senthil Raja A ., Dr.A.N.Sahu,  Department of Pharmaceutical             Engineering and Technology, Indian Institute of Technology (Banaras Hindu University).
         Sponsor: Sprouting grant- Indian Institute of Technology (Banaras Hindu University), 2013-2015
 

  • Project Title: “Pharmacological evaluation of sertraline in alcohol preferring post-traumatic stress disorder rats”:
Principal Investigator: Sairam Krishnamurthy
Sponsor: Faculty-grant- Indian Institute of Technology (Banaras Hindu University), 2016.
  • Project Title: “Experimental Evaluation of Geroprotective Activity of Some Compounds”.
 Principal Investigator: Sairam Krishnamurthy
Sponsor: Natreon Inc.USA., 2016-2018.

 

  • Project Title: “Evaluation of some compounds in experimental Alzheimer’s Disease” .
 Principal Investigator: Sairam Krishnamurthy
Sponsor: Natreon Inc.USA,. 2016-2018.

 

  • Project Title: “Pharmacological effect of novel formulation in experimental allergic encephalomyelitis rodent model”.
 Principal Investigator: Sairam Krishnamurthy
 Sponsor: M/S Disto Pharmaceuticals Pvt. Ltd. India. 2016.

 

  • Project Title: “Pharmacology of Natural Drugs in Obesity and Eating Disorders”.
 Principal Investigator: Sairam Krishnamurthy
Sponsor: Natreon Inc.USA.,.2018-2020.
  • Project Title:”Development of novel near infrared fluorescence imaging probes for detecting amyloid beta species in eyes of Alzheimer’s disease animal model “

 
Principal Investigator: Dr. G.P.. Modi, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University).
Co- Principal Investigator: Sairam Krishnamurthy
Sponsor : ICMR  2019-2022
 

  • Project Title: “Pharmacological evaluation of anti-diabetic effects of some natural drugs”.

 
Principal Investigator: Sairam Krishnamurthy
Sponsor: Natreon Inc.USA.,.2019-2021.
 

  1.   “Disubstituted Piperidine and Piperazine Compounds”. By Peter A. Crooks, Linda P. Dwoskin , Guangrong Zheng, Marlon Jones, Dennis K. Miller, Seth Norrholm and Sairam Krishnamurthy (Docket No. 64684-024),U.S. Patent Application, filed April 1st, 2004
  2. “2,6-Disubstituted Piperidines and Pierazine Compounds”. By Peter A. Crooks, Linda P. Dwoskin , Marlon D. Jones, Dennis K. Miller, Seth D. Norholm, Guangrong Zheng and Sairam Krishamurthy, U.S. Patent Application No. 10/813,647, March 31st, 2004.
  3. “2,6 -Disubstitued Piperidines and Piperazine Compounds”. By Peter A. Crooks, Linda P. Dwoskin , Guangrong Zheng, Dennis K. Miller, Seth D. Norholm, Sairam Krishamurthy and Marlon D. Jones, U.S. Patent No.US2004/266824, December 30th, 2004
  4. “2, 6-Disubstituted Piperidines and Piperazine Compounds”. By Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng, Dennis K. Miller, Seth D. Norholm, Sairam Krishnamurthy  and Marlon D. Jones, U.S. Patent No. 7,368,443, May 6th, 2008.
  5. “An Oral Composition Of Indole-3-Carbinol and A Method Of Preparation Thereof” by Sairam Krishnamurthy , Pankaj Paliwal and Gaurav Chauhan. Indian Patent filed on July 28, 2017, Application No. 201711026941.
  6. “An Oral Bioactive Glass Formulation Containing Aqueous Micronized Barium Oxide for Treating Gastro-Duodenal Ulcers” by Sairam Krishnamurthy, Pankaj Paliwal and Sampath Kumar Arepalli. Indian Patent filed on September 8, 2017, Application No. 201711031854.
  7. “A Bioactive Glass Based Formulation for Treating Cerebral Ischemic Reperfusion Injury And Method Thereof” by Sairam Krishnamurthy and Pankaj Paliwal. Indian Patent filed on September 11, 2017, Application No. 201711032099.
  8. “A Bioactive Glass Scaffold and A Method of Preparation Thereof” by Sairam Krishnamurthy, Pankaj Paliwal, Shreyasi Majumdar and Sampath Kumar Arepalli. Indian Patent filed on 6th oct2017. Application No. 201711035474.
  9. “Formulation of silver containing bioactive glass” by Sairam Krishnamurthy, Pankaj Paliwal Indian Patent filed on 11th May 2018. Application No.  201811017805
  10.  “A Novel Formulation of Dabigatran Solid Dispersion Formulation and a Method of Preparation Thereof” by Sairam Krishnamurthy, Pankaj Paliwal. Indian Patent filed on 3rd  August 2018. Application No.  201811029316.
  11. “A novel barium bioactive glass (BaBG) formulation and a method thereof” by Sairam Krishnamurthy, Pankaj Paliwal and Smriti Gupta Indian Patent filed on September 10, 2018, under Application No. 201811033966.
  12. “A bioactive glass drug formulation for bone repair and regeneration and a method of preparation thereof” by Sairam Krishnamurthy and Pankaj Paliwal; Indian Patent filed on October 25, 2018, under Application No. 201811040152.
  13. A novel anti‐coagulant formulation and a method of preparation thereof by Sairam Krishnamurthy Pankaj Paliwal, Gyan Prakash Modi, Gopichand Gutti, and Sushil K Singh; Indian Patent filed on March 27, 2019, under Application No. 201911012094.
  14. Material for faster bone healing Pralay Maiti, Arun Kumar Mahanta, Sairam Krishnamurthy and Pankaj Paliwal; Indian Patent filed on April 02, 2019, under Application No. 201911013103.

Pre-clinical drug discovery

  • Animal model development and validation:

Development of a chronic model for PTSD for pharmacological evaluation of experimental drugs.

  • Neuropharmacology:

Fields of research:  Post-traumatic stress disorder, Parkinson’s disease, Alzheimer’s disease, Multiple sclerosis, Cerebral Ischemia, Neonatal Anoxia and circadian rhythm disorders.

  • Target identification and validation:

Characterization of mitochondria as a target for PTSD in animal models.
Role of GABA receptors as alternate targets for treatment of type2 diabetes mellitus.
Characterization of mitochondria as a target for neonatal asphyxia.
Alternative mechanism of action of selective serotonin reuptake inhibitors.
Glucocerobosidase as a target for Parkinson’s disease.

  • New drug discovery:

Collaborative research on development of compounds for treatment of Alzheimer’s disease. .

  • Pharmacology of Biomaterials:

Development and validation of inorganic biomaterials for pharmacological use.

  • Ethnopharmacology:

Pharmacological evaluation of Indian traditional drugs.

  • Toxicology:

Preclinical toxicity testing.

  • Biomagnetism:

Biological effects electromagnetic radiations.
 

  1. Sairam Krishnamurthy, Rao Ch V  and Goel RK . 1999. Drug Prescription in Elderly. Journal of Internal Medicine of India 2:288-291.
  2. Sairam K and Sailaja Vani Batchu (2003) Treatment of Gastroduodenal ulcers: An Ayurvedic Perspective. In: Scientific Basis of Ayurvedic Therapy, Misra LK (editor), CRC press California, USA: pp.393-410.
  3. DebapriyaGarabadu and Sairam Krishnamurthy (2013) Temporal Effect of Repeated Stress on Type-2 Experimental Diabetes In: Diabetes Mellitus and Human Health Care A Holistic Approach to Diagnosis and Treatment.Editors: Anne George, MD., Robin Augustine and Mathew Sebastian, MD(eds), Apple Academic Press Inc, USA: Chapter 9.
  4. Paliwal P., Krishnamurthy S., Kumar G., Patnaik R. (2019) Critical Role of Mitochondrial Autophagy in Cerebral Stroke. In: Patnaik R., Tripathi A., Dwivedi A. (eds) Advancement in the Pathophysiology of Cerebral Stroke. 73-82.Springer, Singapore
  5. Kumar G., Mukherjee S., Paliwal P., Tripathi A.K., Krishnamurthy S., Patnaik R. (2019) Stem Cell-Based Therapy for Ischemic Stroke. In: Patnaik R., Tripathi A., Dwivedi A. (eds) Advancement in the Pathophysiology of Cerebral Stroke. 103-121. Springer, Singapore
  All Since 2014
Citations 4252 2205
h-index 34 29
i10-index 57 54

Google citation as on 16-9-19
Nature citation:
Gupta SK, Krishnamurthy S  (2018) Electromagnetic radiation 2450 MHz exposure causes cognition deficit with mitochondrial dysfunction and activation of intrinsic pathway of apoptosis in rats. Journal of biosciences. Cited by Nature-India; 3G mobile phone, wi-fi frequencies damage rat brains; 25 June 2018; | doi:10.1038/nindia.2018.79