gpmodi.phe's picture
Dr. Gyan Prakash Modi
Assistant Professor
Department of Pharmaceutical Engineering and Technology IIT BHU
gpmodi.phe@iitbhu.ac.in
7310008444
Area of Interest: 
Drug Discovery and Development

 

  1. Biomolecular basis of Matrix Metallo Protenase -9 (MMP-9) activity. (Accepted for Publication in Furture Medicinal Chemistry)
  2. Secreatase Inhibitors for The Tretatment of Alzheimer’s Disease: Long Road ahead (Accepted for Publication in  European J of Med. Chem.)
  3. Inhibition of IMPDH from Bacillus anthracis: Mechanism revealed by pre-steady state kinetics. Yang Wei, Petr Kuzmic, Runhan Yu, Gyan Modi and Lizbeth Hedstrom (Journal of Biochemistry, 2016, 55 (37), 5279-88)
  4. Inhibitors of IMPDH from mycobacterium tuberculosis with antitubercular activity. Magdalena Makowska-Grzyska, Youngchang Kim, Suresh Kumar Gorla, Yang Wei, Kavitha Mandapati, Minjia Zhang, Natalia Maltseva, Gyan Modi, Helena I. Boshoff, Minyi Gu, Courtney Aldrich, Gregory D. Cuny, Lizbeth Hedstrom and Andrzej Joachimiak. (Plos One, Pubished on Oct. 6, 2015, DOI:10.1371/journal.pone.0138976)
  5. Dopamine D3 agonists in the treatment of Parkinson’s disease. Banibrata Das, Gyan Modi, Aloke Dutta (Invited review in Current Topics in Medicinal Chemistry, 2015,15, 10, 908-926)
  6. Understanding the structural requirements of hybrid (S)-6-((2-(4-phenylpiperazin-1-yl)ethyl)(propyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol and its analogs as D2/D3 receptor ligands: A three-dimensional quantitative structure-activity relationship (3D QSAR) investigation. Gyan Modi, Horrick Sharma, Prashant Kharkar*, Aloke K. Dutta*, (MedChemComm, 2014, 5, 1384-1399)
  7. Multifunctional D2/D3 agonist D-520 with high in vivo efficacy: Modulation of toxicity of alpha synuclein aggregates. Gyan Modi, Chandrashekhar Voshavar, Sanjib Gogoi, Mrudang Shah, Tamara Antonio, Maarten E.A. Reith, Aloke K. Dutta (ACS Chemical Neuroscience, 2014, 5, 700-717).
  8. Structural modifications of neuroprotective anti-Parkinsonian (-)-N6-(2-(4-(Biphenyl-4-yl)piperazin-1-yl)-ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (D-264): An effort towards the improvement of brain penetration property of the parent molecule. Gyan Modi, Tamara Antonio, Maarten Reith, Aloke Dutta. (J. Med. Chem., 2014, 57, 1557-1572).
  9. Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency. Sanjib Gogoi, Swati Biswas, Gyan Modi, Tamara Antonio, Maarten Reith,  Aloke K. Dutta. (Medicinal Chemistry Letter, 2012, 3(12), 991-996)
  10. Further structure activity relationship studies on 4-((((3S,6S)- 6-Benzhydryltetrahydro-2H-pyran-3- yl)amino)methyl)phenol: Identification of compounds with triple uptake inhibitory activity as potential antidepressant agents.  Bhaskar Gopishetty, Stuart Hazeldine, Soumava Santra, Mark Johnson, Gyan Modi, Solav Ali, Juan Zhen, Maarten Reith, and Aloke Dutta. (J. Med. Chem., 2011, 54, 2924–2932)