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Dr. Deepak Kumar
Assistant Professor and Ramalingaswami Fellow
Department of Pharmaceutical Engineering and Technology, IIT(BHU)
deepak.phe@iitbhu.ac.in
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Area of Interest: 
Medicinal Chemistry, Fluorescence/Bioluminescence Chemistry, Computational Chemistry

Education 
B. Pharmacy, Guru Gobind Singh College of Pharmacy, Kurukshetra University, Haryana.
M. Pharmacy, ISF College of Pharmacy, Punjab Technical University, Punjab.
Ph.D., CSIR-Indian Institute of Integrative Medicine, Jammu, India with Professor (Dr.) Debaraj Mukherjee.
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Postdoctoral Training
University of Illinois (Emeritus Prof.(Dr.) Alan P Kozikowski), Chicago, USA.
University of Massachusetts Medical School (Prof. (Dr.) Stephen C Miller), Massachusetts, USA.
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Employment
Assistant Professor, Department of Pharmaceutical Engg. and Tech., IIT-BHU, Varanasi, UP.

Prestigious Awards
SERB-National Postdoctoral Fellowship
Ramalingaswami Reentry Fellowship

 

Our group is currently working on three different but complementary topics, namely Medicinal Chemistry, Fluorescence/Bioluminescence Chemistry, and Computational Chemistry. Our research lies at the interface between chemistry and biology. 

2021​
1. P. Grover, D. K Sharma, A. K. Chhalodia, D. Mukherjee, Mutasynthesis of Medicinally Significant Natural Products through the Manipulation of Gene Governing Starter Unit, Current Organic Chemistry, DOI : 10.2174/1385272825666210603102557 
2. HK Indurthi, R Virdi, P Koli, D Nageswara Rao, DK Sharma,"Seralite SRC-120 resin catalyzed synthesis of bis (indolyl) methanes using indoles and low/high boiling point carbonyl compounds under solvent free conditions" Synthetic Communications, 139-150, 51, 2021.
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2019-20​
1. Papita Koli, Reena, Rukmankesh Mehra, Deepak K. Sharma "Structure‐Activity Relationship of Indolylkojylmethane Based on Antiproliferative Activity against Breast Cancer" ChemistrySelect, 12417-12420, 5, 2020.
2. P. Koli, Reena, H K Indurthi, ''Anticancer Activity of 3,3′‐Diindolylmethane and the Molecular Mechanism Involved in Various Cancer Cell Lines''. ChemistrySelect, 11540-11548, 5, 2020.
3. D. K Sharma, S. T Adams Jr, K. L Liebmann, A. Choi, S. C Miller “Sulfonamides Are an Overlooked Class of Electron Donors in Luminogenic Luciferins and Fluorescent Dyes", Org. Lett. 1641–1644, 21, 2019.
4. D. Nayak, A. Katoch, D. Sharma, M.M. Faheem, S. Chakraborty, P. K. Sahu, N. A. Chikan, H. Amin, A. P. Gupta, S. G. Gandhi, D. Mukherjee, A. Goswami. "Indolylkojylmethane analogue IKM5 potentially inhibits invasion of breast cancer cells via attenuation of GRP78" Breast Cancer Research and Treatment, 307-323, 177, 2019.
5. D. K. Sharma, A. Magotra, A. Gour, A. K. Dash, G. Singh, D. Mukherjee, U. Nandi, " Pharmacokinetic evaluation of medicinally important synthetic N,N′ diindolylmethane glucoside: Improved synthesis and metabolic stability” Bioorg. Med. Chem. Lett. 1007-1011, 29, 2019. 
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2017-18
1. A. Katoch, S. Suklabaidya, S. Chakraborty, D. Nayak, R. U. Rasool, D. Sharma, D. Mukherjee, M. M. Faheem, A. Kumar, P. R. Sharma, S. Senapati, L. D. Kumar, A. Goswami "Dual Role of Par-4 in abrogation of EMT and switching on Mesenchymal to Epithelial Transition (MET) in metastatic pancreatic cancer cells". Molecular Carcinogenesis, 1102-1115, 57, 2018.
2. D. K Sharma, S. T Adams Jr, K. L Liebmann, S. C Miller, "Rapid Access to a Broad Range of 6′-Substituted Firefly Luciferin Analogues Reveals Surprising Emitters and Inhibitors.", Org. Lett. 5836–5839, 19, 2017.
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2014-16
1. D. K. Sharma, S Jaglan, D Mukherjee, "Isolation and conversion of Penicillic acid to 6-iodo-α-pyran-2, 5-dione: A key intermediate for the synthesis of Pectinolide F" Synthetic Communications, 902-908, 46, 2016.
2. D. K. Sharma, V. S. Rajput, S. Singh, R. Sharma, I. A. Khan, D. Mukherjee, "Ligand Free Palladium Catalyzed Synthesis of 3-Aryl/heteroaryl-4-Indolylmaleimide and its Antimicrobial Activity." Chemistry SELECT, 1954-1958, 1, 2016. 
3. D. Nayak, H. Amin, B. Rah, R. ur Rasool, D. K. Sharma, A. P. Gupta, M. Kushwaha, D. Mukherjee, A. Goswami., "A therapeutically relevant 3,3'-diindolylmethane derivative NGD16 attenuates angiogenesis by targeting glucose regulated protein, 78 kDa (GRP78)."Chem. Biol. Interact., 58-67, 232, 2015. 
4. D. K. Sharma, J.Pandey,A. K. Tamrakar,D. Mukherjee, “Synthesis of heteroaryl/arylkojic acid conjugates as stimulators of glucose uptake by GLUT4 translocation” Eur. J. Med. Chem. 727-736, 85, 2014.
5. D. K. Sharma, B. Singh,D. Mukherjee,“Aldol reaction of kojic acid using alumina supported base catalyst and enzymatic resolution of the aldol adduct by CALB” Tetrahedron lett. 5846–5850, 55, 2014.
6. M. Lambu, A. Hussain, D. K. Sharma, S. K. yousuf, B. Singh, A. K. Tripati, D. Mukherjee, “Synthesis of C-spiro-glycoconjugates from sugar lactones via zinc mediated Barbier reaction” RSC Adv., 11023-11028, 4, 2014.
7. D. K. Sharma, A. K. Tripathi, R. Sharma, R. Chib, R. ur Rasool, A. Hussain, B. Singh, A. Goswami, I. A. Khan, D. Mukherjee, “A new class of bactericidal agents against S. aureus, MRSA and VRE derived from bisindolylmethane” Med. Chem. Res., 1643-1653,23, 2014. 
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2011-2013
1. A. Hussain, S. K. Yousuf, D. K. Sharma, M.Lambu, B. Singh, D. Mukherjee,“Design and synthesis of carbohydrate based medium sized sulphur containing benzannulated macrocycles; Applications of Sonogashira and Heck coupling” Tetrahedron, 5517-5524,69, 2013.
2. M. Lambu, S. Kumar, S. K. Yousuf, D. K. Sharma, A. Hussain, A. Kumar, F. Malik, D. Mukherjee, “Medicinal chemistry of dihydropyran based medium ring macrolides related to aspergillides: selective inhibition of PI3K-alpha” J. Med. Chem., 6122–6135, 56, 2013. 
3. D. K. Sharma, M. Lambu, T. Sidiq, A. Khajuria, A. K. Tripathi, S. Khalid Yousuf, D.Mukherjee, "Ammonium chloride mediated synthesis of alkyl glycosides and evaluationof their immunomodulatory activity" RSC Adv., 11450-11455, 3, 2013.
4. D. K. Sharma, A. Hussain, M. Lambu, S. K. Yousuf, S. Maity, B. Singh, D. Mukherjee,“Fe/Al pillard clay catalyzed solvent-free synthesis of bisindolylmethanes using diverslysubstituted indoles and carbonyl compounds” RSC Adv., 2211-2215, 3, 2013.
5. A. Hussain, D. K. Sharma, A. K. Tripathi, B. Singh, D. Mukherjee, “Synthesis of carbohydrate fused chiral macrocyclic benzolactones through Sonogashira reaction” RSC Adv., 19899-19904, 3, 2013.
6. D. K. Sharma, B. Rah, M. Lambu, A. Hussain, S.K. Yousuf, G. jamwal, Z. Ahmed, N. Chanauria, A. Nargotra, A. K. Tripathi, B. Singh, A. Goswami, D. Mukherjee, “Design and synthesis of novel N, N’-glycoside derivatives of 3,3’-diindolylmethanes as potential antiproliferative agents” Med. Chem. Comm. 1082-1091, 3, 2012.
7. A. Hussain, S. K. Yousuf, D. K. Sharma, M. Lambu, A. K. Tripathi, B. Singh, S.Maiety, D. Mukherjee, “Synthesis of benzannulated chiral macrocycles embeddedin acarbohydrate template by intramolecular base free Sonogashira reaction on alumina support" Adv. Synt. And Catal., 1933–1940, 354, 2012. 
8. S. K. Yousuf, A. Hussain, D. K. Sharma, A. H. Wani, B. Singh, S. C. Taneja, D. Mukherjee, “Stereoselective conversion of dihydropyran, dihydrofuran and glycals to 1-azido-2-halo derivatives using NIS/NBS -TMSN3 combination”J. Carbohydrate Chem., 61-74, 30, 2011. 

Book Chapters
1. Deepak Kumar, S. K.Yousuf, D. Mukherjee. “Mutasynthesis of medicinally importantnatural products through manipulation of gene governing starter unit” Nat. Prod. Med.Chem. (Research Signpost) 368-391, 2010.
2. Recent Trends in synthesis of chromene....... submitted
 
Patents
Indolylkojylmethane analogues, process of preparation thereof, and use as inhibitor of cancer cell invasion and metastasis.Date of Grant 27/06/2017, D. Mukherjee, A. Goswami, D. Sharma, D. Nayak, S. K. Jain (WO 2019/003237, PCT/IN2018/050060), Country: IN, US, CN, CA, AU, EP

Ph.D.

Harish K Indurthi (Junior Research Fellow, DBT)
Mr. Harish K Indurthi obtained his Bachelor in Pharmacy in 2017 from Acharya Nagarjuna University, Guntur, Andhra Pradesh and Masters from National Institute of Pharmaceutical Education and Research, Mohali, Punjab India in 2019.  He is currently working in DBT sponsored project on bioluminescence-based monitoring of tumor progression and treatment by apoptotic pathway.

Samarpita Das (PhD-IIT Fellowship)
Ms Samarpita Das completed B.Pharm from Gupta College of Technological Sciences affiliated to MAKAUT  (Previously known as WBUT) in 2018 and M.S. (Pharm.) degree from NIPER (Mohali) in 2020. Her PhD research work is synthesis of novel analogues of diindolylmethane for anticancer activity.

M. Pharmacy

Papita Koli
Pulkit Asati
Komal

11. Ms Samarpita Das joined our group (March, 2021) as PhD research fellow. Welcome Samarpita
10. Harish got admission in IIT-BHU PhD course. Congratulation Harish.
9. Harish research paper published in Synthetic Communication, Nov. 2020. Congratulation Harish.
8. Harish K Indurthi has joined our group as DBT-JRF, Nov, 2020. Welcome Harish.
7. Papita Koli review article published in Chemistry Select, Oct. 2020. Congratulation Papita.
6. Papita Koli research paper published in Chemistry Select, Sep. 2020. Congratulation Papita.
5. Harish K. Indurthi got selected as JRF in DBT sponsored research grant, March, 2021.
4. Papita Koli has joined our group for M. Pharm Research Project, Feb, 2020. Welcome Papita.
3. Deepak received seed grant from IIT-BHU, Jan. 2020
2. Deepak recevied prestigious Ramalingaswami research grant for 5 years, Dec. 2019.
1. Dr. Deepak K Sharma joined Assistant Professor in Department of Pharmaceutical Engg and Tech. IIT-BHU, November, 2019.

We are always interested in applications from qualified candidates having their own fellowship at postdoctoral and research associate levels.
Please send your cover letter and resume to deepak.phe@itbhu.ac.in
Part-time students and summer students are encouraged to apply.