asraja.phe's picture
Dr. Senthil Raja A.
Associate Professor
Department of Pharmaceutical Engineering & Technology IIT BHU
asraja.phe@iitbhu.ac.in
9453313140
Area of Interest: 
Pharmaceutical and Medicinal Chemistry, Computational Chemistry, Drug Design

Native of Sankagiri, Salem District, Tamilnadu.

Educational Background

  • B Pharm (1999): The Tamilnadu Dr.MGR Medical University, Chennai.
  • M Pharm (2002): Institute of Technology (Banaras Hindu University) Varanasi.
  • PhD (2008): Institute of Technology (Banaras Hindu University) Varanasi.

Teaching Experience: 15 years

Courses Taught

      Undergraduate

  • Essentials of Biochemistry ( CY103, Institute Course)
  • Pharmaceutical Chemistry (PH221)
  • Computational Chemistry (PH421)
  • Computational Drug Design (PH525)

     Postgraduate

  • Spectroscopy (PH503)

     PhD

  • Advanced Spectral Techniques (PH7201)

 

  • Synthetic Medicinal Chemistry - Conventional and Microwave-Assisted Organic Synthesis of Bio-active Compounds.
  • Computational Chemistry & Molecular Modeling - Structure-Based Drug Design and Discovery of Heterocyclic Lead Compounds as Neurotherapeutic agents and Anticancer agents.
  • Papers Published in National & International Journals: 18
  • Abstracts in National & International Conferences: 27

List of Publications
 
  • Raja Ayyannan, S. , M S, Vishnu. , Vangavelu, P. and Kumar, S. (2019), Experimental and computational evaluation of some piperonylic acid derived hydrazones bearing isatin moiety as dual inhibitors of cholinesterases and monoamine oxidases. ChemMedChem. Accepted Author Manuscript. doi:10.1002/cmdc.201900277 
  • Rati K.P.Tripathi, Senthil Raja A. Monoamine Oxidase-B Inhibitors as Potential Neurotherapeutic Agents – An overview and update. Medicinal Research Reviews, 2019,1-104, (DOI: 10.1002/med.21561) (IF: 8.5)
  • Shivani J, Rati K.P.Tripathi, Senthil Raja A. Scaffold Hopping-Guided Design of Some Isatin Based Rigid Analogs as Fatty Acid Amide Hydrolase Inhibitors: Synthesis and Evaluation Biomed Pharmcother, 2018 107,1611–1623 (IF: 2.8)
  • Rati K.P.Tripathi, Vishnu, MS, Sukesh KG, Sairam K, Senthil Raja A Design, synthesis, and pharmacological evaluation of 2-amino-5-nitrothiazole derived semicarbazones as dual inhibitors of MAO and AChE: effect of the size of aryl binding site, J Enz Inhibition Med Chem 2017, 33 (1), 37-57. (IF: 4.2)
  • Rati K.P.Tripathi, Senthil Raja A Evaluation of 2-amino-6-nitrobenzothiazole derived hydrazones as acetylcholinesterase inhibitors: In-vitro assays, molecular docking and theoretical ADMET prediction. Med Chem Res, 2017, 1-17 (IF: 1.2)
  • Rati K.P.Tripathi, Senthil Raja A Anticonvulsant activity, organotypic hippocampal neuroprotection assay and in-silico sodium channel blocking potential of 2-amino-6-nitrobenzothiazole derived semicarbazones. Biomed Pharmcother, 2017, 95, 1451-1460. (IF: 2.8)
  • Rati K.P.Tripathi, Senthil Raja A Design, synthesis and evaluation of some 2-amino-6-nitrobenzothiazole derived hydrazones as MAO inhibitors - Role of methylene spacer group. ChemMedChem, 2016, 11 (14), 1551-1567. (IF: 2.96)
  • Rati K.P.Tripathi, Gopal K. Rai, Senthil Raja A.  Exploration of a library of 3,4-(methylenedioxy)aniline derived semicarbazones as dual inhibitors of monoamine oxidase and acetylcholinesterase: design, synthesis and evaluation. ChemMedChem, 2016, 11 (11) 1145-1160. (IF: 2.96)
  • Rati K.P.Tripathi, Senthil Raja A. Discovery of 3-Hydroxy-3-phenacyloxindole analogues of isatin as potential inhibitors of monoamine oxidase, ChemMedChem, 2016, 11 (1), 119-132. (IF: 2.96)
  • Pankaj Mishra, Senthil R Ayyannan, Gautam Panda. Perspectives on inhibiting beta-amyloid aggregation through structure-based drug design, ChemMedChem, 2015, 10 (9), 1467–1474. (IF: 2.96)
  • Rati K.P.T., Omprakash G, Senthil Raja A. Design, synthesis, in vitro MAO-B inhibitory evaluation, and computational studies of some novel 6-Nitrobenzothiazole-derived semicarbazones, ChemMedChem, 2013, 8(3), 462-474. (IF: 3.1)
  • A S Raja, A K Agarwal, N Mahajan, S N Pandeya and S. Ananthan “Antibacterial and antitubercular activities of some diphenyl hydrazones and semicarbazones” Ind. J. Chem. Sec B, 49B, 10, 2010, 1384-1388. (IF: 0.397)
  • Raja, A. S, Pandeya, S. N., Panda, S. S and Stables, J. P. “Synthesis, anticonvulsant and antidepressant evaluation of semicarbazones of acetophenone Mannich bases” Pharmaceutical Chemistry Journal, V.41, N.6, 15-19 (2007). (IF: 0.452)
  • Pandeya, S. N., Raja, A. S and Nath G. “Synthesis and antimicrobial evaluation of 4- or 6-chloroisatin derivatives” Ind. J. Chem. Sec B, 45B, 2, 2006, 494-499. (IF: 0.397)
  • Pandeya, S. N., Raja, A. S and Nath, G. “Synthesis and antibacterial activities of N-benzylisatin-3-semicarbazones and hydrazones”. Indian Drugs, 41(3), 2004, 134-137.
  • Raja, A. S., Current approaches to validation of analytical chemical methods, The Pharmstudent, 24, 2003, 56-67.
  • Raja, A. S., and Ram Kumar, R., “Analgesic activity of chloroxylon swietenia” Indian Drugs, 40(1), 2003, 275-278.
  • Pandeya, S. N., Raja, A. S and Stables, J. P. “ Synthesis of isatin semicarbazones as potential anticonvulsants – Role of hydrogen bonding” J. Pharm. Pharmaceut. Sci., 5(3), 2002, 275-280. (IF: 1.8)
Research Guidance
  • PhD: 01 completed; 02 ongoing
  • M Pharm: 16 completed; 02 ongoing
  • IDD: 03 completed

Current Students

  • Ms. Shivani Jaiswal (PhD Thesis)
  • Ms. Ojaswi Sinha (PhD Thesis)
  • Mr. J Harish (MPharm Thesis) 
  • Mr. Samarth D (MPharm Thesis) 
  • Mr. Vaibhav Raj (IDD Thesis)

Former Students

  • Ms. Rati K P Tripathi (MPharm 2011; PhD 2016)
  • Mr. Vishnu MS (IDD, 2018)
  • Mr. Pavan Kumar (MPharm, 2018)
  • Mr. Shiladitya Palit (MPharm, 2018)
  • Mr. Vipin Arya (MPharm, 2017)
  • Mr. Sandeep Kumar (MPharm, 2017)
  • Ms. Dipika (IDD, 2017)
  • Ms. Kanchan Verma (M Pharm, 2016)
  • Ms. Ruchi S Pathak (MPharm. 2016)
  • Mr. Bhanu Pratap (IDD, 2016)
  • Mr. Ankita Kausal (MPharm. 2014)
  • Mr. Omprakash Goshain (MPharm, 2011)
  • Mr. Shaik Mohammed Ayyaz (IDD, 2011)
  • Mr. Gopal K Rai (MPharm. 2010)
  • Mr. Abhimanyu (MPharm. 2009)
  • Mr. Chhanda Charan Danta (MPharm. 2009)
  • Mr. Anjaneyulu Putta (MPharm. 2007)
  • Mr. Nishant Mahajan (MPharm 2005)
  • Association of Pharmaceutical Teachers of India (APTI)
  • Indian Pharmacy Graduates Association (IPGA)
  • Pharmaceutical Society, BHU
  • Mahamana Malaviya Foundation
  • Delivered an invited lecture on “Research-based undergraduate curriculum for sustainable development” during the National Seminar organized at School of Education, Gandhigram Rural Institute, Dindigul (TN), during Jan 2019.
  • Delivered an invited talk on "Role of chemists in current drug discovery and development" at Shanmuga College of Pharmacy, Sankari (TN), during Jan 2019.
  • Delivered an invited lecture on “Current approaches to Molecular Modeling” during the National Seminar organized at Nirmala College of Pharmacy, Muvaatuuzha (Kerala), during Nov 2016.
  • Delivered an invited lecture on “Modern drug design tools – Approaches and challenges” during the one day workshop organized at JKKNCP, Komarapalayam (TN) during Feb 2010.
  • Delivered an invited lecture on “Principles, challenges, and applications of drug design” during the workshop on Drug Design and Molecular Modeling at JKKNCP, Komarapalayam (TN) during Jul 2008.
  • Delivered a lecture on "Drug Design – Modern approaches and Challenges" during a one-day Workshop at Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamilnadu. (2006)
  • Delivered an invited lecture on “Method validation and applications” during the AICTE sponsored workshop organized at Lachoo Memorial College of Science & Technology (Pharmacy Wing), Jodhpur during May 2004. 
  • Germany
  • The Netherlands
  • Singapore
Curricular Activities
  • APAN India Fellow awarded by ERNET India, 32nd Asia-Pacific Advanced Network (APAN) Meeting held at New Delhi, during 22-26, August 2011.
  • Travel Grant Award by Department of Biotechnology, New Delhi for presenting a research paper in the International Conference "MedChem Europe 2011" held at Germany.
  • Junior Research Fellowship awarded by UGC during 2000-2002.
Extra-Curricular Activities
  • Won Silver Medal (Inter IIT Staff Volleyball Championship) during the 25th Inter IIT Staff Sports Meet 2018 held at IIT, Guwahati. 
  • Won Bronze Medal (Inter IIT Staff Volleyball Championship) during the 24th Inter IIT Staff Sports Meet 2017 held at IIT, Madras.
  • Won Bronze Medal (Inter IIT Staff Volleyball Championship) during the 23rd Inter IIT Staff Sports Meet 2016 held at IIT, Kanpur.
  • Won Gold Medal (Inter IIT Staff Volleyball Championship) during the 22nd Inter IIT Staff Sports Meet 2014 held at IIT, Bombay.
  • Represented IIT (BHU), as Vice Caption of IIT Volleyball team during the 22nd Inter IIT Staff Sports Meet 2014 held at IIT, Bombay.
  • Represented IIT (BHU) in the IIT Volleyball team during the 21st Inter IIT Staff Sports Meet 2013 held at IIT, Guwahati.
  • Represented IT-BHU Volleyball team during Spardha (Annual All India Sports Festival) 2002 and secured First position in the event.
  • Represented IT-BHU Volleyball team during Spardha (Annual All India Sports Festival) 2001 and secured Second position in the event.