asraja.phe's picture
Dr. Senthil Raja A.
Associate Professor
Department of Pharmaceutical Engineering & Technology IIT BHU
asraja.phe@iitbhu.ac.in
9453313140
Area of Interest: 
Pharmaceutical and Medicinal Chemistry, Computational Chemistry, Drug Design

Native of Sankagiri, Salem District, TN.

Educational Background

  • PhD (2008): Institute of Technology (Banaras Hindu University) Varanasi.
  • M Pharm (2002): Institute of Technology (Banaras Hindu University) Varanasi.
  • B Pharm (1999): The Tamilnadu Dr.MGR Medical University, Chennai.

Teaching Experience: 16 years

Courses Taught
Undergraduate

  • Essentials of Biochemistry ( CY103, Institute Course)
  • Pharmaceutical Chemistry (PH221)
  • Computational Chemistry (PH421)
  • Computational Drug Design (PH525)

     Postgraduate

  • Spectroscopy (PH503)

     PhD

  • Advanced Spectral Techniques (PH7201)

 

  • Synthetic Medicinal Chemistry - Conventional and Microwave-Assisted Organic Synthesis of Bioactive Compounds.
  • Computational Chemistry & Molecular Modeling - Ligand-based & Structure-Based Drug Design and Discovery of Heterocyclic Compounds as Neurotherapeutic agents and Anticancer agents.
Publications in Journals
  • Raja Ayyannan, S. , M S, Vishnu. , Vangavelu, P. and Kumar, S., Experimental and computational evaluation of some piperonylic acid derived hydrazones bearing isatin moiety as dual inhibitors of cholinesterases and monoamine oxidases. ChemMedChem. 2019, doi:10.1002/cmdc.201900277, (IF: 3.016) 
  • Rati K.P.Tripathi, Senthil Raja A. Monoamine Oxidase-B Inhibitors as Potential Neurotherapeutic Agents – An overview and update. Medicinal Research Reviews, 2019,1-104, (DOI: 10.1002/med.21561) (IF: 8.5)
  • Shivani J, Rati K.P.Tripathi, Senthil Raja A. Scaffold Hopping-Guided Design of Some Isatin Based Rigid Analogs as Fatty Acid Amide Hydrolase Inhibitors: Synthesis and Evaluation Biomed Pharmcother, 2018 107,1611–1623 (IF: 2.8)
  • Rati K.P.Tripathi, Vishnu, MS, Sukesh KG, Sairam K, Senthil Raja A Design, synthesis, and pharmacological evaluation of 2-amino-5-nitrothiazole derived semicarbazones as dual inhibitors of MAO and AChE: effect of the size of aryl binding site, J Enz Inhibition Med Chem 2017, 33 (1), 37-57. (IF: 4.2)
  • Rati K.P.Tripathi, Senthil Raja A Evaluation of 2-amino-6-nitrobenzothiazole derived hydrazones as acetylcholinesterase inhibitors: In-vitro assays, molecular docking and theoretical ADMET prediction. Med Chem Res, 2017, 1-17 (IF: 1.2)
  • Rati K.P.Tripathi, Senthil Raja A Anticonvulsant activity, organotypic hippocampal neuroprotection assay and in-silico sodium channel blocking potential of 2-amino-6-nitrobenzothiazole derived semicarbazones. Biomed Pharmacother, 2017, 95, 1451-1460. (IF: 2.8)
  • Rati K.P.Tripathi, Senthil Raja A Design, synthesis and evaluation of some 2-amino-6-nitrobenzothiazole derived hydrazones as MAO inhibitors - Role of methylene spacer group. ChemMedChem, 2016, 11 (14), 1551-1567. (IF: 3.016)
  • Rati K.P.Tripathi, Gopal K. Rai, Senthil Raja A.  Exploration of a library of 3,4-(methylenedioxy)aniline derived semicarbazones as dual inhibitors of monoamine oxidase and acetylcholinesterase: design, synthesis and evaluation. ChemMedChem, 2016, 11 (11) 1145-1160. (IF: 3.016)
  • Rati K.P.Tripathi, Senthil Raja A. Discovery of 3-Hydroxy-3-phenacyloxindole analogues of isatin as potential inhibitors of monoamine oxidase, ChemMedChem, 2016, 11 (1), 119-132. (IF: 2.96)
  • Pankaj Mishra, Senthil R Ayyannan, Gautam Panda. Perspectives on inhibiting beta-amyloid aggregation through structure-based drug design, ChemMedChem, 2015, 10 (9), 1467–1474. (IF: 3.016)
  • Rati K.P.T., Omprakash G, Senthil Raja A. Design, synthesis, in vitro MAO-B inhibitory evaluation, and computational studies of some novel 6-Nitrobenzothiazole-derived semicarbazones, ChemMedChem, 2013, 8(3), 462-474. (IF: 3.016)
  • A S Raja, A K Agarwal, N Mahajan, S N Pandeya and S. Ananthan “Antibacterial and antitubercular activities of some diphenyl hydrazones and semicarbazones” Ind. J. Chem. Sec B, 49B, 10, 2010, 1384-1388. (IF: 0.397)
  • Raja, A. S, Pandeya, S. N., Panda, S. S and Stables, J. P. “Synthesis, anticonvulsant and antidepressant evaluation of semicarbazones of acetophenone Mannich bases” Pharmaceutical Chemistry Journal, V.41, N.6, 15-19 (2007). (IF: 0.452)
  • Pandeya, S. N., Raja, A. S and Nath G. “Synthesis and antimicrobial evaluation of 4- or 6-chloroisatin derivatives” Ind. J. Chem. Sec B, 45B, 2, 2006, 494-499. (IF: 0.397)
  • Pandeya, S. N., Raja, A. S and Nath, G. “Synthesis and antibacterial activities of N-benzylisatin-3-semicarbazones and hydrazones”. Indian Drugs, 41(3), 2004, 134-137.
  • Raja, A. S., Current approaches to validation of analytical chemical methods, The Pharmstudent, 24, 2003, 56-67.
  • Raja, A. S., and Ram Kumar, R., “Analgesic activity of chloroxylon swietenia” Indian Drugs, 40(1), 2003, 275-278.
  • Pandeya, S. N., Raja, A. S and Stables, J. P. “ Synthesis of isatin semicarbazones as potential anticonvulsants – Role of hydrogen bonding” J. Pharm. Pharmaceut. Sci., 5(3), 2002, 275-280. (IF: 1.8)

Conference Presentations
  1. Sandeep Kumar, Vishnu, MM, Senthil Raja A. “Exploration of a library of benzimidazole derived hydrazones as dual inhibitors of acetylcholinesterase and monoamine oxidases” in the international conference on “Emerging Trends in Drug Discovery and Development” (ETDDD-2018) from 18th -20th January 2018, Department of Agricultural science, BHU.
  2. Shivani Jaiswal, Senthil Raja A, Nira Mishra, Scaffold hopping hided design of some isatin based rigid analogs as fatty acid amide hydrolase inhibitors – synthesis and evaluation. World Health Congress – 2017, 21-22 August 2017, held at Hyderabad.
  3. Vishnu, MM, Senthil Raja A. “Protein crystallography and structure-based drug design – promising tools in the discovery of potent neurotherapeutic agents” in the 45th National Seminar on Crystallography (NSC 45) from 9th - 12th July 2017, IIT (BHU).
  4. Vishnu, MM, Senthil Raja A. Presented research poster in the INDO-GERMAN Workshop on Recent Applications of Carbohydrates in Chemistry and Biology (RACCB-2017), International Workshop, IIT(BHU) during 14th-16th February 2017, titled “Discovery of 2-amino-5-nitrothiazole and 5-aminobenzo[1,3]dioxole derived semicarbazones as dual inhibitors of monoamine oxidase and acetylcholinesterase: Synthesis, in silico and in vitro evaluation”.
  5. Rati K P Tripathi, Senthil Raja Ayyannan. Synthesis and evaluation of some benzothiazole based hydrazones as potential MAO-A inhibitors. International Conference on Multifunctional Materials for Future Applications, during 27 – 29, October 2015, IIT (BHU), Varanasi
  6. Abhimanyu, Rati Kailash Prasad Tripathi, Senthil Raja Ayyannan Anticonvulsant activity of some isomeric dimethyl substituted aryl semicarbazones Tetrahedron Symposium, Asia Edition, Singapore, during October 2014
  7. Rati K. P. Tripathi, Senthil R. Ayyannan Monoamine oxidase inhibitory evaluation of some 3-substituted-3-hydroxyoxindole analogues of isatin International Symposium on Recent Advances in Medicinal Chemistry (ISRAM – 2014), organized NIPER, S. A. S. Nagar during 8th – 10th September, 2014.
  8. Rati K. Tripathi, Senthil R. Ayyannan, Design, synthesis, in-vitro and computational evaluation of some     N-substituted propargylamine derivatives as MAO inhibitors. DSIN-RSC Conference – Overcoming the Bottlenecks in Drug Discovery and Development, organized by Royal Society of Chemistry and Daiichi Sankyo/Ranbaxy Research Laboratories, Gurgaon, Haryana during 20th – 21st March, 2014.
  9. Rati Kailash P. Tripathi, Gopal K. Rai, Senthil R. Ayyannan, Design, synthesis and evaluation of some 6-substituted benzothiazole derived semicarbazones as monoamine oxidase inhibitors, National Symposium on Organic Synthesis and Advanced Materials (NSOSAM – 2014), organized by Department of Chemistry, Faculty of Science, BHU, Varanasi, U.P., during 1st – 2nd March, 2014
  10. Tripathi Rati, Ayyannan Senthil Raja, Design, synthesis, in-vitro and in-silico evaluation of some 3-hydroxy-3-phenacyloxindole analogues of isatin as MAO inhibitors, NIPiCON 2014 – International Conference on Fostering Innovation in Drug Discovery and Development, organized by Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, during 23rd – 25th January, 2014
  11. Rati Kailash P. Tripathi, Gopal K. Rai, Senthil Raja A., Design, synthesis, in-vitro biological and computational evaluation of 2-Amino-6-nitrobenzothiazole based hydrazones as potential monoamine oxidase inhibitors, 6th International RBF Symposium, organized by Zydus Research Centre, Ahmedabad during 4th – 6th February, 2013
  12. Nazmi Z, Tripathi R. K. P., Acharya P. C., Raja A. S., Design, synthesis and anticonvulsant evaluation of some novel Schiff bases of 2-amino-5-[4-substituted aryloxymethyl]-1,3,4-thiadiazol-2-amines, 64th Indian Pharmaceutical Congress, organized by SRM University, Chennai during 7th – 9th December, 2012
  13. Senthil Raja Ayyannan, Paras Nath Singh, Surendra Nath Pandeya, James P Stables, “Design and synthesis of conformationally rigid analogs of isatin semicarbazones as potential anticonvulsants – Development of a pharmacophore model” Research paper presented in the “MedChem Europe 2011” held on 28-29 March 2011, Germany.
  14. Senthil Raja A, Rati K.P.T and Gopal K.R. Design, synthesis, antidepressant and monoamine oxidase inhibitory properties of Schiff’s bases of 2-amino-4-choroquinazoline, poster presented in the International conference “RAPS 2010” held on 22-23 December 2010, BHU, India.
  15. Senthil Raja A, Omprakash G and Chhanda Charan D. Pharmacophore based design and synthesis of new quinazoline-4(3H)-one derivatives as anticonvulsant agents - poster presented in the International conference “RAPS 2010” held on 22-23 December 2010, BHU, India.
  16. Pandeya S N, Raja A S, Singh P N, Stables J P. Design and Synthesis of N-allylisatin-3-semicarbazones as Potential Anticonvulsants: Development of a New Pharmacophore Model - Research paper presented during 2009 AAPS Annual Meeting and Exposition, being held November 8-12 at the Los Angeles Center in Los Angeles, California.
  17. Raja A S, Putta A, Acharya P C, Nath G. “Synthesis and preliminary antibacterial investigation of 4-Fluoro and 2,4-dichloro substituted aryl semicarbazones” - Paper presented in the 57th Indian Pharmaceutical Congress 2007, held at Varanasi.
  18. Pandeya S N, Raja A S, Kumar A. “Synthesis, anticonvulsant and neurotoxic activity of salicylic acid hydrazones and Schiff’s bases” -Paper presented in the 57th Indian Pharmaceutical Congress 2007, held at Varanasi.
  19. Pandeya, S. N., Raja, A. S., Panda, S. S and Ananthan, S “Synthesis and preliminary antibacterial and antimycobacterial investigation of semicarbazones of acetophenone Mannich bases”- Paper presented in the 57th Indian Pharmaceutical Congress 2005, held at Hyderabad.
  20. Pandeya, S. N., Raja, A. S. and Mahajan, N. “Antidepressant and sedative-hypnotic activity of some isatin semicarbazones and hydrazones”- Paper presented in the 56th Indian Pharmaceutical Congress 2004 held at Kolkata.
  21. Pandeya, S. N, Raja, A. S., Agrawal, A. K., Thakkar, D and Mahajan, N. “Synthesis and CNS evaluation of Phenoxy/p-bromophenoxy acetic acid hydrazones (Schiff bases) - Paper presented in the 56th Indian Pharmaceutical Congress 2004 held at Kolkata.
  22. Nagori, B. P. and Raja, A. S. “Current approaches to the validation of analytical methods”- Paper presented in a national seminar at Jai Narayan Vyas University, Jodhpur in 2004.

Research Guidance
  • PhD: 01 completed; 02 ongoing
  • M Pharm: 18 completed; 02 ongoing
  • IDD: 05 completed

Current Students

  • Ms. Shivani Jaiswal (PhD Thesis)
  • Ms. Ojaswi Sinha (PhD Thesis)
  • Mr. Sandeep Kumar (PhD Thesis)
  • Mr. P. Pegu (M Pharm Thesis)
  • Ms. Surabhi (M Pharm Thesis)

Former Students

  • Ms. Rati K P Tripathi (MPh 2011; PhD 2016)
    • Current position: Assistant Professor, Parul University, Baroda.
  • Mr. J Harish (MPharm Thesis) 
    • Current position: Chemist, Cadilla Pharmaceuticals, Ahmadabad.
  • Mr. Samarth D (MPharm Thesis) 
    • Current position: Assistant Professor, TMU, Moradabad..
  • Mr. Vaibhav Raj (IDD Thesis)
  • Mr. Vishnu MS (IDD, 2018)
  • Mr. Pavan Kumar (MPharm, 2018)
    • Current position: Chemist, Syngene Ltd, Bangalore.
  • Mr. Shiladitya Palit (MPharm, 2018)
    • Current position: Chemist, Dr. Reddy;s Lab, Hyderabad.
  • Mr. Vipin Arya (MPharm, 2017)
    • Current position: Chemist, Sun Pharmaceuticals, Gurgaon.
  • Ms. Dipika (IDD, 2017)
  • Ms. Kanchan Verma (M Pharm, 2016)
  • Ms. Ruchi S Pathak (MPharm. 2016)
  • Mr. Bhanu Pratap (IDD, 2016)
  • Mr. Ankita Kausal (MPharm. 2014)
  • Mr. Omprakash Goshain (MPharm, 2011)
  • Mr. Shaik Mohammed Ayyaz (IDD, 2011)
  • Mr. Gopal K Rai (MPharm. 2010)
  • Mr. Abhimanyu (MPharm. 2009)
  • Mr. Chhanda Charan Danta (MPharm. 2009)
  • Mr. Anjaneyulu Putta (MPharm. 2007)
  • Mr. Nishant Mahajan (MPharm 2005)
  • Association of Pharmaceutical Teachers of India (APTI), Bangalore.
  • Indian Pharmacy Graduates Association (IPGA), New Delhi.
  • Pharmaceutical Society, BHU.
  • Mahamana Malaviya Foundation, Varanasi.
  • Delivered an invited lecture on “Emerging trends in Data Science - A boon for better healthcare” at Nandha College of Arts & Science, Erode (TN), on 01 Jul 2019.
  • Delivered an invited talk on "Role of chemists in current drug discovery and development" at Shanmuga College of Pharmacy, Sankagiri (TN), during 24 Jan 2019.
  • Delivered an invited lecture on “Research-based undergraduate curriculum for sustainable development” during the National Seminar organized at School of Education, Gandhigram Rural Institute, Dindigul (TN), on 18 Jan 2019.
  • Delivered an invited lecture on “Current approaches to Molecular Modeling” during the National Seminar organized at Nirmala College of Pharmacy, Muvaatupuzha (Kerala), on 05 Nov 2016.
  • Delivered an invited lecture on “Modern drug design tools – Approaches and challenges” during the one day workshop organized at JKKNCP, Komarapalayam (TN) on 16 Feb 2010.
  • Delivered an invited lecture on “Principles, challenges, and applications of drug design” during the workshop on Drug Design and Molecular Modeling at JKKNCP, Komarapalayam (TN) during Jul 2008.
  • Delivered a lecture on "Drug Design – Modern approaches and Challenges" during a one-day Workshop at Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamilnadu (TN). (2006)
  • Delivered an invited lecture on “Method validation and applications” during the AICTE sponsored workshop organized at Lachoo Memorial College of Science & Technology (Pharmacy Wing), Jodhpur (Rajasthan) during May 2004. 
  • Germany
  • The Netherlands
  • Singapore
Curricular Activities
  • APAN India Fellow awarded by ERNET India, 32nd Asia-Pacific Advanced Network (APAN) Meeting held at New Delhi, during 22-26, August 2011.
  • Travel Grant Award by Department of Biotechnology, New Delhi for presenting a research paper in the International Conference "MedChem Europe 2011" held at Germany.
  • Junior Research Fellowship awarded by UGC during 2000-2002.
Extra-Curricular Activities
  • Won Silver Medal (Inter IIT Staff Volleyball Championship) during the 25th Inter IIT Staff Sports Meet 2018 held at IIT, Guwahati. 
  • Won Bronze Medal (Inter IIT Staff Volleyball Championship) during the 24th Inter IIT Staff Sports Meet 2017 held at IIT, Madras.
  • Won Bronze Medal (Inter IIT Staff Volleyball Championship) during the 23rd Inter IIT Staff Sports Meet 2016 held at IIT, Kanpur.
  • Won Gold Medal (Inter IIT Staff Volleyball Championship) during the 22nd Inter IIT Staff Sports Meet 2014 held at IIT, Bombay.
  • Represented IIT (BHU), as Vice Caption of IIT Volleyball team during the 22nd Inter IIT Staff Sports Meet 2014 held at IIT, Bombay.
  • Represented IIT (BHU) in the IIT Volleyball team during the 21st Inter IIT Staff Sports Meet 2013 held at IIT, Guwahati.
  • Represented IT-BHU Volleyball team during Spardha (Annual All India Sports Festival) 2002 and secured First position in the event.
  • Represented IT-BHU Volleyball team during Spardha (Annual All India Sports Festival) 2001 and secured Second position in the event.