vkdubey.bce's picture
Dr. Vikash Kumar Dubey
Professor
School of Biochemical Engineering IIT BHU
vkdubey.bce@iitbhu.ac.in
Intercom No: 3723
Area of Interest: 
Cell Death Pathways and Diseases; Protein Biochemistry; Protein Engineering, Biochemical Parasitology; Isolation and Purification of Commercially Important Enzymes

Biography

Prof. Vikash Kumar Dubey is currently Professor at School of Biochemical Engineering, IIT (BHU), Varanasi since May 2018. He is also Associate Dean (Academic Affairs), IIT (BHU) and looking after undergraduate academic affairs. Before joining IIT (BHU), he was Professor (January 2014 to May 2018) at IIT Guwahati where he has also served as Assistant Professor/Associate Professor (2006 onward). He has several administrative experiences at IIT Guwahati at various levels including Head, Chairman (Student Welfare Board), Faculty-in-Charge etc. He is also a member of various national level committees, expert committees, faculty selection committee member etc. He has published over 125 articles in peer reviewed Journal(s) and over 75 conference presentations/proceedings/invited talks. He has seven awarded and licensed USA patents as well as three Indian patents applications to his credit. He has also written several book chapters and one NPTEL online course (40 lectures). His scientific contributions are recognised by several awards, fellowship/membership of national/international scientific societies/ academies, Editorship of several journals etc.  He has guided seventeen PhD students (14 awarded and 03 submitted/pre-PhD given), fourteen MTech students, several postdoctoral fellows, project fellows,  trainees etc.

 Professional Experience

--May 2018- till date : Professor, School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi.
-January 2014-  May 2018: Professor, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati.
-December 2009- January 2014: Associate Professor, Department of Biotechnology, Indian Institute of Technology Guwahati.
-September 2006- November 2009: Assistant Professor, Department of Biotechnology, Indian Institute of Technology Guwahati.
-January 2004- September 2006: Post-Doctoral Research Associate, Florida State University, Tallahassee, Florida, USA.
-September 2002-January 2003: Fellow of Intituto Pasteur-Foundazione Cenci Biolognetti, Rome, Italy.
-Senior Research Fellowship, CSIR, Government of India
-Training Fellowship from Intituto Pasteur-Foundazione Cenci Biolognetti, Rome, Italy.
-Junior Research Fellowship, CSIR, Government of India.
-Qualified national eligibility test (CSIR-NET), for research fellowship and eligibility for lectureship.

Membership of Scientific Society

-Fellow, Royal Society of Biology, United Kingdom
- Fellow: National academy of Biological sciences
-Fellow:Biotechnology Research Society of India
-Fellow:Association of Biotechnology and Pharmacy
-The National Academy of Sciences, India: Life member. ( MNASc)
- Fellow: Society of Applied Biotechnology
- Member, International Society of Infectious Diseases
-Bioinformatics and Drug Discovery Society : Life member.
- Society of Biological Chemist (India): Life member.
-Biotechnology Research Society of India: Life member.
- Leishmaniasis Research Society (India): Life member.
-Association of Biotechnology and Pharmacy: Life member.
- Indian Science Congress Association : Life member.
- National academy of Biological sciences: Life member.

Awards and Recognitions

  • Member, Board of Governors (April 2017-April 2019 ), The Biotech Research Society of India (BRSI).
  • Elected as FRSB (Fellow, Royal Society of Biology, United Kingdom ) : 1-Jan. 2018 onward
  • Vice President , Bioinformatics and Drug Discovery Society [BIDDS] (July 2017 onward)
  • Prize for Biomedical Research Conducted in Underdeveloped areas–2016 by Indian Council for Medical Research, Government of India
  • Dr. P.N. Raju Oration Award-2012 by Indian Council for Medical Research, Government of India
  • Elected as FBRS (Fellow, Biotech Research Society) of India in recognition of outstanding research contributions to Medical Biotechnology (2014)
  • Elected as FABP (Fellow, Association of Biotechnology and Pharmacy ) in recognition of outstanding research contributions to Medical Biotechnology (2014)
  • Prof. Umakant Sinha Memorial Award of the Indian Science Congress Association (ISCA) for the year 2013-2014
  • B.M. Birla Science Prize in Biology for Year 2012 
  • Malviya Memorial Award (Young Faculty) for 2011 by Biotech Research Society of India (Nov., 2012).
  • Elected as Fellow of National Academy of Biological Sciences (July, 2013).
  • Extended Innovative Young Biotechnologist Award by DBT. Government of India (July 2013) [Cash prize Rs. 2 Lakhs for 2 more years with additional project funding].
  • Innovative Young Biotechnologist Award for 2009 (IYBA-2009) by DBT. Government of India February 2010 [Gold medal,Citation,Cash prize Rs. 3 Lakhs for 3 years period along with a major project funding].
  • Young Scientist Award for 2009 by Biotech Research Society of India [The award consists of a citation and medal].
  • Young Scientist Award (2009-10) by National Academy of Agriculture Sciences [Citation, a gold plated silver medal and cash prize of Rs. 25,000]
  • Young Scientist Award for 2009-10 by Indian Society of Chemists and Biologists ( ISCB) [The award consists of a citation, medal and cash prize].
  • Young Scientist Award for 2011 by Society of Applied Biotechnology, Award ceremony was held at Kolhapur, Maharashtra, Feb. 24, 2012.
  • Awarded "Bharat Joyoti Award" for meritorious services and outstanding performance by India International Friendship Society (2012).
  • Associate Fellow: National Academy of Agriculture Sciences, India.
  • Elected as MNASc (Member, The National Academy of Sciences, India). April 2010.

Student Awards (under my supervision)

  • PhD work of Mr. Gundappa Saha has been awarded Prime minister doctoral Fellowship. It is a unique, highest-paying scholarship of Science & Engineering Research Board, Department of Science and Technology, Government of India and Confederation of Indian Industry. He is working on Leishmania project in collaboration with Cadila Pharmaceuticals Limited.
  • Prakash Saudagar and Vikash Kumar Dubey. "Betulin attached to functionalized carbon nanotubes showed better efficacy against Leishmania parasite". 2nd International Conference on Infectious Diseases and Nanomedicine-2015 (ICIDN-2015), Kathmandu, Nepal,December 15-18, 2015. [ Best poster Award ].
  •  

    Mr. Ritesh Kumar , PhD student with Dr. V.K. Dubey, received Best poster Award at International Conference on "Future Prospects of Advancements in Biological Sciences, Health Issues & Environmental Protection; on 07 - 08 Feb, 2014 at Indira Gandhi Pratishthan, Lucknow

  • Ms. Mousumi Das, PhD student with Dr. V.K. Dubey, received Best Oral Presentation Award during International Conference on Health, Environment and Industrial Biotechnology BioSangam -2013. Allahabad, November 21 - 23, 2013
  • Mr. Prakash Saudagar, PhD student with Dr. V.K. Dubey, received Best poster Award during 80th Annual Meeting of Society of Biological Chemists, India held at Lucknow, November 12-15, 2011.
  • Mr. Anil Kumar Shukla, Ph.D student withr Dr. V.K. Dubey, has been awarded travel award by Department of Science and Technology for attending European Molecular Biology Organization (EMBO) meeting 2011 held at Vienna.
  • Ms. Nandini Sarkar, PhD student with Dr. V.K. Dubey, awarded International Union of Biochemistry and Molecular Biology (IUBMB) full travel fellowship to attend 21st IUBMB and 12th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) International Congress of Biochemistry and Molecular Biology held during 2-7 August 2009 in Shanghai, China.
  • Ms. Nandini Sarkar, PhD student with Dr. V.K. Dubey, received Young Scientist Program Award : 21st International Union of Biochemistry and Molecular Biology (IUBMB) and 12th Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) International Congress of Biochemistry and Molecular Biology held during 2-7 August 2009 in Shanghai, China.
  • Ms. Nandini Sarkar, PhD student with Dr. V.K. Dubey, received B.S Narasinga Rao Best poster Award during 77th Annual Meeting of Society of Biological Chemists, India held at IIT Madras, Chennai December 18-20, 2008
  •  
  • Any Other Relevant Information
    • Associate Editor: Scientific Report Nature Publishing Group: July 2015
    • Associate Editor: Journal of Proteins and Proteomics : Dec. 2008 onward [ Publisher:  Springer]
    • Editorial Board Member: Protein and Peptide Letters [Bentham Science Journal; Impact factor 1.99) : Jan. 2014 onward
    • Associate Editor : BMC Biotechnology (Impact factor 2.59) : July 2014 -July 2017
    • Editorial Board member: Dataset Papers in Biology [Biotechnology section and Biophysics section]: 2013-2014
    • Editorial Board member: ISRN Structural Biology (Hindawi Journal): 2013 onward
    • Editorial Board member: Cloning & Transgenesis (Omics Group Journal): 2013 onward
    • Editorial Advisory board: Advances in Natural and Applied Sciences.
    • Editor: Biotechnology and Molecular Biology Reviews : Dec. 2008 onward
    • Editorial Advisory board: International Journal of Medical Sciences and Technology.
    • Editorial Advisory board: International Journal of Life Sciences and Technology.
    • Editorial Advisory board: International Journal of BioSciences, Healthcare Technology and Management (IJBHTM).
    • Editor board member of International Journal of BioSciences and Technology; International Journal of Biological Sciences and Technology; International Journal of BioSciences, Psychiatry and Technology ; International Journal of Innovation; International Journal of BioSciences, Agriculture and Technology.
    • Editorial Review Board member of Scientific Journals International (SJI).
    • Reviewer for several journals like Biochemistry (ACS), Phytochemistry, International Journal of Biological Macromolecules, Biotechnology, Medicinal Chemistry (ACS), Process Biochemistry, Parasitology International, Experimental parasitology, Parasitology Research, Acta Tropica, PLOS journals, and Molecular Biology Reviews etc.
    • https://publons.com/author/1000683/prof-vikash-kumar-dubey#profile)
    • Senior Research Fellowship, CSIR, Government of India.
    • Training Fellowship from Intituto Pasteur-Foundazione Cenci Biolognetti, Rome, Italy.
    • Junior Research Fellowship, CSIR, Government of India.
    • Qualified national eligibility test (CSIR-NET), for research fellowship and eligibility for lectureship.

Publications (May 2018 onward..)

123. Gianni Colotti, Roberto Di Santo, Marina Gramiccia, Trentina Di Muccio, Jay Prakash, Sunita Yadav, Vikash Kumar Dubey, Theo Battista, Aasia Bibi and Andrea Ilari. Structure-guided approach to identify a novel class of anti-leishmaniasis diaryl sulfide compounds targeting the trypanothione metabolism.Amino acid, Accepted, [Publisher: Springer]

122. Prakash J, Yadav S, Saha G, Chiranjivi AK, Kumar S, Sasidharan S, Saudagar P, Dubey VK*. Episomal expression of human glutathione reductase (HuGR) in Leishmania sheds light on evolutionary pressure for unique redox metabolism pathway: Impaired stress tolerance ability of Leishmania donovani. Int J Biol Macromol. 2019 Jan;121:498-507. [*Corresponding author; Publisher: Elsevier].

121. Shyamali Sarma, DavidOrtega, Nigel P.Minton,Vikash Kumar Dubey,Vijayanand S.Moholkar, Homologous overexpression of hydrogenase and glycerol dehydrogenase in Clostridium pasteurianum to enhance hydrogen production from crude glycerol, Bioresource Technology, 2019, 284, 168-177 [Publisher: Elsevier].

120. Verma K, Saha G, Kundu LM, Dubey VK*. Biochemical characterization of a stable azoreductase enzyme from Chromobacterium violaceum: Application in industrial effluent dye degradation. Int J Biol Macromol. 2019, 121:1011-1018. [*Corresponding author; Publisher: Elsevier].

119. Barman J, Kumar R, Saha G, Tiwari K, Dubey VK*. Apoptosis: Mediator Molecules, Interplay with Other Cell Death Processes and Therapeutic Potentials. Curr Pharm Biotechnol. 2018;19(8):644-663.[*Corresponding author; Publisher: Bentham].

118. Saha G, Khamar BM, Singh OP, Sundar S, Dubey VK*. Leishmania donovani evades Caspase 1 dependent host defense mechanism during infection. Int J Biol Macromol. 2018 22;126:392-401[*Corresponding author; Publisher: Elsevier]. Media covereage of the article: https://www.natureasia.com/en/nindia/article/10.1038/nindia.2019.1

117. Najar IN, Sherpa MT, Das S, Verma K, Dubey VK, Thakur N. Geobacillus yumthangensis sp. nov., a thermophilic bacterium isolated from a north-east Indian hot spring. Int J Syst Evol Microbiol. 2018 68(11):3430-3434.

Publications before May 2018
115. 
Anupriya Baranwal, Adarsh Kumar Chiranjivi, Ashutosh Kumar, Vikash Kumar Dubey* , and Pranjal Chandra* Design of commercially comparable nanotherapeutic agent against human disease-causing parasite, Leishmania.  Scientific Reports, 20188(1):8814*Joint Corresponding author; Publisher: Nature Publishing Group]

114. Kartikeya Tiwari and Vikash Kumar Dubey*. Leishmania donovani asparaginase variants exhibit cytosolic localization. . International Journal of Biological Macromol. 2018, 114, 35-39 [*Corresponding author; Publisher: Elsevier].

113. Adarsh Chiranjivi and Vikash Kumar Dubey*. Dihydrolipoamide dehydrogenase from Leishmania donovani: New insights through biochemical characterization. International Journal of Biological Macromol. 2018, 112:1241-124. [*Corresponding author; Publisher: Elsevier].

112. Prachi Bhalla, Sabera Sultana, Adarsh Chiranjivi, Anil Saikia and Vikash Kumar Dubey*. synthesis of Methyl 4-(7-hydroxy-4,4,8-trimethyl-3-oxabicyclo[3.3.1]nonan-2-yl)benzoate and their evaluation as anti-leishmanial: Synergistic effect with Miltefosine. Antimicrobial Agents and Chemotherapy, 2018, pii: AAC.01810-17. doi: 10.1128/AAC.01810-17. [Epub ahead of print] . [*Corresponding author; Publisher: American Society of Microbiology].

111. Kartikeya Tiwari and Vikash Kumar Dubey. * Fresh insights into the pyrimidine metabolism in the trypanosomatids. Parasites & Vectors 2018, In press, [*Corresponding author; Publisher: BioMed Central].

110. Vidhya V. M., Vikash Kumar Dubey and Karthe Ponnuraj. Identification of two natural compound inhibitors of Leishmania donovani Spermidine Synthase (SpdS) through molecular docking and dynamic studies. J Biomol Struct Dyn. 2017 Sep 5:1-16. doi: 10.1080/07391102.2017.1366947. [Publisher: Taylor and Francis].

109. Shalini Singh, Ekta Kumari, Ruchika Bhardwaj, Ritesh Kumar and Vikash Kumar Dubey*. Molecular events leading to death of Leishmania donovani under spermidine starvation after hypericin treatment. Chemical Biology & Drug Design, 2017, 90, 962-971 [*Corresponding author; Publisher: Wiley] Media coverage

108. Ritesh Kumar, Kartikeya Tiwari and Vikash Kumar Dubey*. Methionine aminopeptidase 2 is a key regulator of apoptotic like cell death in Leishmania donovan, Scientific Reports, 2017, 7: 95. [*Corresponding author;Publisher: Nature Publishing Group]. Research Highlight of the article published in Nature India.

107. Ruchika Bhardwaj , Mousumi Das , Shalini Singh, Adarsh Kumar Chiranjivi, Sitraraau Vijaya Prabhu , Sanjeev Kumar Singh and Vikash Kumar Dubey *

Evaluation of CAAX prenyl protease II of Leishmania donovani as potential drug target: infectivity and growth of the parasite is significantly lowered after the gene knockout. European Journal of Pharmaceutical Sciences , 2017, 102,156-160 [*Corresponding author; Publisher: Elsevier].

106. Shyamali Sarma, Avinash Anand, Vikash Kumar Dubey, V.S. Moholkar. Metabolic flux network analysis of hydrogen production from crude glycerol by Clostridium pasteurianum. Bioresource Technology, 2017, S0960-8524(17)30450-9 [ Publisher: Elsevier].

105. Sitrarasu Vijaya Prabhu, Kartikeya Tiwari, Venkatesan Suryanarayanan, Vikash Kumar Dubey* and Sanjeev Kumar Singh*. Exploration of potent molecules against CAAX prenyl protease I of Leishmania donovani through Pharmacophore based virtual screening approach. Combinatorial Chemistry & High Throughput Screening, 2017, 20, 255-271 [*Joint corresponding authors; Publisher: Bentham Science].

104. Sudipta Ghosh, Rajesh K Singh, Vikash Kumar Dubey and Latha Rangan . Antileishmanial Activity of Labdane Diterpenes Isolated from Alpinia nigra Seeds. Letters in Drug Design and Discovery, 2017, 14, 119-124( [Publisher: Bentham Science].

103. Shilpa N. Patere, Pankaj O. Pathak, Anil Kumar Shukla, Rajesh Kumar Singh, Vikash Kumar Dubey, Miten J. Mehta, Anand G. Patil, Vikram Gota, Mangal S. Nagarsenker.. Surface-Modified Liposomal Formulation of Amphotericin B: In vitro Evaluation of Potential Against Visceral Leishmaniasis. AAPS PharmSciTech. 2017, 18, 710-720. [Publisher: Springer@ American Association of Pharmaceutical Scientists].

102. Kartikeya Tiwari , Ritesh Kumar and Vikash Kumar Dubey * . Biochemical characterization of dihydroorotase of Leishmania donovani: Understanding pyrimidine metabolism through its inhibition. Biochimie, 2016, 131, 45-53 [*Corresponding author; Publisher: Elsevier].

101. Ritesh Kumar, Pratyajit Mohapatra and Vikash Kumar Dubey* . Exploring realm of proteases of Leishmania donovani genome and gene expression analysis of proteases under apoptotic condition . Journal of Proteomics & Bioinformatics , 2016, 9: 200-208. doi:10.4172/ jpb.1000407 [*Corresponding author; Publisher: Omics Journal]

100. Ruchika Bhardwaj , Sanjeev Kumar Singh and Vikash Kumar Dubey* . Localization studies on LdBPK _070020, a conserved protein, of Leishmania donovani. Journal of Vector Borne Diseases, 2016, 53, 375-378. [*Corresponding author; Publisher: Medknow@ Indian Council of Medical Research]

99. Shyamali Sarma, Vikash K Dubey and Vijayanand Suryakant Moholkar . Kinetic and thermodynamic analysis (with statistical optimization) of hydrogen production from crude glycerol using Clostridium pasteurianum. International Journal of Hydrogen Energy, 2016, 41, 19972–19989 [Publisher: Elsevier]

98. Shalini Singh and Vikash Kumar Dubey*. Quantitative proteome analysis of Leishmania donovani under spermidine starvation. Plos One, 2016 PLoS ONE 11(4): e0154262. doi:10.1371/journal.pone.0154262 [*Corresponding author].

97. Ruchika Bhardwaj, Ritesh Kumar, Sanjeev Kumar Singh, Chandrabose Selvaraj and Vikash Kumar Dubey*. Understanding the importance of conservative hypothetical protein LdBPK_070020 in Leishmania donovani and its role in subsistence of the parasite. Archives of Biochemistry and Biophysics, 2016, 596, 10-21[*Corresponding author; Publisher: Elsevier].

96. Klionsky DJ, Abdelmohsen K, Abe A, Abedin , MJ, Abeliovich H,---(-----)--- Vikash Kumar Dubey,---(--------)--- Zughaier SM. Guidelines for the use and interpretation of assays for monitoring autophagy, Autophagy. 2016, 12, 1-222

95. Anil K. Saikia*, Sabera Sultana, Ngangbam Renubala Devi,Manash J. Deka,Kartikeya Tiwari, Vikash K. Dubey* Diastereoselective Synthesis of Substituted Hexahydrobenzo[de]isochromans and their Evaluation as Antileishmanial activity, Organic & Biomolecular Chemistry, 2016, 14,:970-9.[Publisher: The Royal Society of Chemistry]

94. Mousumi Das, Shalini Singh and Vikash Kumar Dubey*. Novel inhibitors of ornithine decarboxylase of Leishmania parasite (LdODC): The parasite resists LdODC inhibition by over-expression of spermidine synthase. Chem Biol Drug Des . 2016, 87, 352-360 [*Corresponding author; Publisher: Wiley]

93Shalini Singh , Sitrarasu Vijaya Prabhu, Venkatesan Suryanarayanan, Ruchika Bhardwaj, Sanjeev Kumar Singh and Vikash Kumar Dubey*. Molecular docking and structure based virtual screening studies of CAAX prenyl protease I &II. Journal of Molecular Structure and Dynamics, 2016, 34, 2367-86. [*Corresponding author; Publisher: Taylor and Francis]

92. Sushant Singh and Vikash Kumar Dubey. Multiwalled carbon nanotube-Superoxide dismutase conjugate towards alleviating induced oxidative stress . International Journal of Peptide Research and Therapeutics , 2016, 22, 171-177 [*Corresponding author; Publisher: Elsevier]

91. Mousumi Das, Gundappa Saha and Vikash Kumar Dubey. Novel leads against miltefosine unresponsive Leishmania donovani . Antimicrobial Agents and Chemotherapy , 2015, 59, 7826-9 [*Corresponding author; Publisher: American Society of Microbiology]

90. Shalini Singh, Shyamali Sarma , Shashank P Katiyar , Mousumi Das , Ruchika Bhardwaj , Durai Sundar Vikash Kumar Dubey*. Probing molecular mechanism of hypericin induced parasitic death: An insight into role of spermidine beyond redox metabolism of Leishmania. Antimicrobial Agents and Chemotherapy, 2015, 59,15-24. [*Corresponding author; Publisher: American Society of Microbiology].

89. Mousumi Das, Ritesh Kumar and Vikash Kumar Dubey*. Ornithine decarboxylase of Leishmania donovani: Biochemical properties and possible role of N-terminal extension . Protein and Peptide Letters , 2015, 22,:130-6 [*Corresponding author; Publisher: Bentham Science ].

88. Prakash Saudagar and Vikash Kumar Dubey*. Carbon Nanotube Based Betulin Formulation shows better efficacy against Leishmania parasite . Parasitology International, 2014, 63, 772-6 [*Corresponding author; Publisher: Elsevier]

 87. Prakash Saudagar, Shyam Lal Mudavath, Pipas Saha, Anil K. Saikia, Shyam Sundar and Vikash Kumar Dubey*. In vivo assessment of antileishmanial property of 4-(4,4,8-Trimethyl-7-oxo-3-oxabicyclo[3.3.1]non-2-yl)-benzoic acid methyl ester, an oxabicyclo[3.3.1]nonanones. Letters in Drug Design and Discovery, 2014,11, 937-939 [*Corresponding author; Publisher: Bentham Science ].

86. Saudagar Prakash and Vikash Kumar Dubey*. Molecular Mechanisms of In vitro Betulin Induced Apoptosis of Leishmania donovani. American Journal of Tropical Medicine and Hygiene . 2014, 90, 354-60 [*Corresponding author; Publisher: American Society of Tropical Medicine and Hygiene ].

85. Vidhyadhar N, Sushant Singh, Abhay N Singh, Vikash Kumar Dubey*. Procerain B, a cysteine protease from Calotropis Procera, requires N-terminus pro-region for activity: cDNA cloning and expression with pro-sequence. Protein Expression and Purification. 2014, 103C:16-22.[*Corresponding author; Publisher: Elsevier]

84. Saravanan Parameswaran, Prakash Saudagar, Vikash Kumar Dubey, Sanjukta Patra. Discovery of novel anti-leishmanial agents targeting LdLip3 lipase. Journal of Molecular Graphics and Modelling 2014, 49, 68–79 [Publisher: Elsevier].

83. Saravanan Parameswaran, Vikash Kumar Dubey, Sanjukta Patra. Emulating structural stability of Pseudomonas mendocina lipase: in silico mutagenesis and moleular dynamics studies. Journal of Molecular Modeling 2014, 20 , 2501 [Publisher: Springer].

82. Mousumi Das, Saudagar Prakash, Shyam Sundar and Vikash Kumar Dubey*. Miltefosine unresponsive Leishmania donovani has better ability of resist reactive oxygen species. FEBS Journal, 2013, 280, 4807–4815 [*Corresponding author; Publisher: Wiley-Blackwell on behalf of the Federation of European Biochemical Societies ].

81 Saudagar Prakash, Pipas Saha , Anil K. Saikia and Vikash Kumar Dubey*. Molecular mechanism underlying antileishmanial effect of oxabicyclo[3.3.1]nonanones: Inhibition of key redox enzymes of the pathogen. European Journal of Pharmaceutics and Biopharmaceutics. 2013, 85, 569-577 [*Corresponding author; Publisher: Elsevier].

80. Sudipta Hazra, Subhalakshmi Ghosh, Madhushree Das Sarma, Mousumi Das, Saudagar Prakash, Vikash Kumar Dubey, Shyam Sundar, Banasri Hazra . Evaluation of a diospyrin derivative as antileishmanial agent and potential modulator of ornithine decarboxylase of Leishmania donovani. Experimental Parasitology, 2013, 135,:407-413 [Publisher: Elsevier].

79. Nandini Sarkar and Vikash Kumar Dubey. Exploring critical determinants of protein amyloidogenesis: A review . Journal of Peptide Science, 2013, 19:529-36 [Publisher: Wiley InterScience]

78. Sushant Singh, Abhay Narayan Singh, Anil Verma and Vikash Kumar Dubey*. Biodegradable Polycaprolactone (PCL) Nanosphere Encapsulating Superoxide Dismutase and Catalase Enzymes. Applied Biochemistry and Biotechnology, 2013, 171,1545-58. [*Corresponding author; Publisher: Springer ]

77. Abhay Narayan Singh, Prity Yadav and Vikash Kumar Dubey*. cDNA cloning and molecular modelling of Procerain B, a novel cysteine protease isolated from Calotropis procera. PLOS ONE, 2013, 8(3): e59806. doi:10.1371/journal.pone.0059806 [*Corresponding author]

76. Abhay Narayan Singh, Sushant Singh and Vikash Kumar Dubey*. Immobilization of Procerain B, a Cysteine Endopeptidase, on Amberlite MB-150 Beads. PLoS ONE 2013, 8(6): e66000.doi: 10.1371/journal.pone.0066000 [*Corresponding author]

75. Sushant Singh, Abhay Narayan Singh, Anil Verma and Vikash Kumar Dubey*. A novel superoxide dismutase from Cicer arietinum L. seedlings: purification and characterization. Protein and Peptide Letters. 2013, 20, 741-8. [*Corresponding author; Publisher: Bentham Science].

74. Sonali Seth, Debamitra Chakrovorty, Vikash Kumar Dubey and Sanjukta Patra. An insight into plant lipase research – challenges encountered. Protein Expression and Purification. 2013 95C: 13-21 [Publisher: Elsevier].

73. N. K. Prasanna Kumari, Vikash Kumar Dubey and Medicherla V. Jagannadham. SDS Induced Refolding of Pre-molten Globule State of Cryptolepain: Differences in Chemical and Temperature-Induced Equilibrium Unfolding of the Protein in SDS-Induced State. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences. 2013, 83, 71-80

72. Rajiv K. Verma, Vijay K. Prajapati, Girijesh K. Verma, Deblina Chakraborty, Shyam Sundar, Madhukar Rai, Vikash Kumar Dubey* and Maya Shankar Singh.* Molecular Docking and in vitro Antileishmanial Evaluation of Chromene-2-thione Analogues. ACS Medicinal Chemistry Letters. 2012, 3, 243-247. [*Joint corresponding author; Publisher: American Chemical Society].

71. Anil K Shukla, Sanjukta Patra and Vikash Kumar Dubey*. PEGylated nanospheres encapsulating antileishmanial drugs for their specific macrophage targeting, reduced toxicity and deliberate intracellular release. Vector-Borne and Zoonotic Diseases, 2012, 12, 953-60 [*Corresponding author]

70. Anil K Shukla, Sanjukta Patra and Vikash Kumar Dubey*. Iridoid glucosides from Nyctanthes arbortristis results in increased Reactive Oxygen Species and cellular redox homeostasis imbalance in Leishmania parasite. European Journal of Medicinal Chemistry , 2012, 54, :49-58 [*Corresponding author; Publisher: Elsevier].

69. Neha Sharma, Anil Kumar Shukla, Mousumi Das and Vikash Kumar Dubey*. Evaluation of plumbagin and its derivative as potential modulator of redox thiol metabolism of Leishmania parasite. Parasitology Research, 2012, 110, 341-348 [*Corresponding author; Publisher: Springer]

68. Abhinav Grover, Shashank Prakash Katiyar, Jeyaraman Jeyakanthan, Vikash Kumar Dubey and Durai Sundar. Blocking protein kinase C signaling pathway: mechanistic insights into the anti-leishmanial activity of prospective herbal drugs from Withania somnifera. BMC Genomics 2012;13 Suppl 7:S20.

67. Ruchika Bhardwaj, Prakash Saudagar and Vikash Kumar Dubey*. Nanobiosciences: A contemporary line for Antiparasitic Drug. Molecular and Cellular Pharmacology, 2012, 4, 97-103 [*Corresponding author].

66. Deblina Chakraborty, Parameswaran Saravanan, Sanjukta Patra and Vikash Kumar Dubey*. Studies on ornithine decarboxylase of Leishmania donovani: Structure modeling and inhibitor docking. Medicinal Chemistry Research, 2012, 167, 439-61 [*Corresponding author; Publisher: Springer].

65. Parameswaran Saravanan, Vikash Kumar Dubey and Sanjukta Patra. Targeting essential cell wall lipase Rv3802c for potential therapeutics against tuberculosis. Journal of Molecular Graphics and Modelling, 2012, 38, 235-42 [Publisher: Elsevier].

64. Manjeet Kumar, Nandini Sarkar, and Vikash Kumar Dubey*. Evaluating quinacrine as a potential amyloid imaging compound: studies on hen egg white lysozyme as model system. Protein and Peptide Lett., 2012, 19, 826-31 [*Corresponding author;Publisher: Bentham Science].

63. Abhinav Grover, Sushil Kumar Shakyawar, Saudagar Prakash, Vikash Kumar Dubey and Durai Sundar. Epitopic analysis of potential vaccine candidate in Leishmania infantum for development of human vaccine. Letters in Drug Design and Discovery, 2012, 9, 698-705 [Publisher: Bentham Science].

62. Abhinav Grover, Shashank Prakash Katiyar, Jeyaraman Jeyakanthan, Vikash Kumar Dubey and Durai Sundar. Mechanistic insights into the dual inhibition strategy for checking leishmaniasis. Journal of Biomolecular Structure & Dynamics. 2012, 30, 474-87 [Publisher: Taylor and Francis].

61. Sushant Singh, Anil Verma and Vikash Kumar Dubey*. Aluminium induced oxidative stress in germinating chickpea ( Cicer arietinum L.) seeds. Brazilian Journal of Plant Physiology, 2012, 24, 47-54 [*Corresponding author].

60. Parameswaran Saravanan, Vikash Kumar Dubey, Sanjukta Patra. Potential Selective Inhibitors against Rv0183 of Mycobacterium tuberculosis Targeting Host Lipid Metabolism. Chemical Biology & Drug Design. 2012, 79, 1056-62 [Publisher: Wiley InterScience] The article is featured as a key scientific article on the Global Medical Discovery web site.

59. Debamitra Chakravorty, Parameswaran Saravanan, Vikash Kumar Dubey, Sanjukta Patra. Unraveling the rationale behind organic solvent stability of lipases. Applied Biochemistry and Biotechnology, 2012, 167, 439 461 [Publisher: Springer]

58. Abhinav Grover, Shashank Prakash Katiyar, Sanjeev Kumar Singh, Vikash Kumar Dubey and Durai Sundar. A Leishmaniasis study: structure-based screening and molecular dynamics mechanistic analysis for discovering potent inhibitors of spermidine synthase. Biochimica et Biophysica Acta - BBA: Proteins and Proteomics, 2012, 1824, 1476-83 [Publisher: Elsevier].

57. Santhosh K. Venkatesan and Vikash Kumar Dubey*. Footprinting of Inhibitor Interactions of in silico identified inhibitors of trypanothione reductase of Leishmania parasite. TheScientificWorldJOURNAL, 2012, Article ID 963658, 13 doi:10.1100/2012/963658 [*Corresponding author]

56. Saudagar Prakash and Vikash Kumar Dubey*. Cloning, expression, characterization, and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani. Biological Chemistry, 2011, 392, 1113-22. [*Corresponding author;Publisher:Walter de Gruyter]

55. Nandini Sarkar; Manjeet Kumar; Vikash Kumar Dubey*. Rottlerin dissolves pre-formed protein amyloid: A study on hen egg white lysozyme. Biochimica et Biophysica Acta-General Subjects, 2011,1810, 809-814 [*Corresponding author; Publisher: Elsevier]

54. Abhay Narayan Singh, Neeraj Suthar, Sushant Singh, and Vikash Kumar Dubey*. Glutaraldehyde activated chitosan matrix for immobilization of a novel cysteine protease, procerain B. Journal of Agricultural and Food Chemistry (ACS), 2011, 59, 6256-62 [*Corresponding author; Publisher:American Chemical Society]

53. Nandini Sarkar, Manjeet Kumar and Vikash Kumar Dubey*. Effect of sodium tetrathionate on amyloid fibril: Insight in to the role of disulfide bond in amyloid progression. Biochimie, 2011, 2011. 93, 962-968 [*Corresponding author; Publisher: Elsevier]. The article is featured as a key scientific article on the Global Medical Discovery web site

52. Nandini Sarkar, Manjeet Kumar and Vikash Kumar Dubey*. Exploring possibility of promiscuity of amyloid inhibitor: Studies on effect of selected compounds on folding and amyloid formation of proteins. Process Biochemistry, 2011, 46, 1179-1185 [*Corresponding author; Publisher: Elsevier].

51.Anil K Shukla, Sanjukta Patra and Vikash Kumar Dubey*. "Evaluation of selected antitumor agents as subversive substrate and potential inhibitor of trypanothione reductase: An alternative approach for chemotherapy of Leishmaniasis". Molecular and Cellular Biochemistry, 2011, 352, 261-70 [*Corresponding author; Publisher: Springer] Research Highlight of the article published in Nature India.

50. Anil K Shukla, Sanjukta Patra and Vikash Kumar Dubey*. Deciphering molecular mechanism underlying antileishmanial activity of Nyctanthes arbortristis, an Indian medicinal plant. Journal of Ethnopharmacology, 2011, 134, 996-998 [*Corresponding author; Publisher: Elsevier]

49. Jihun Lee, Sachiko I. Blaber, Vikash K. Dubey and Michael Blaber. A polypeptide "building block" for the -trefoil fold identified by "top-down symmetric deconstruction. Journal of Molecular Biology, 2011, 407, 744-63. [Publisher: Elsevier].

The article is featured as a key scientific article on the Global Medical Discovery web site. The article is selected by the Faculty of 1000 (F1000), which places the work in the top 2% of published articles in biology and medicine.

[Cover page article April 15, 2012 issue of Journal of Molecular Biology ].

48. Bankapallai Leela Krishna, Abhay Narain Singh, Sanjukta Patra* and Vikash Kumar Dubey*. Purification, characterization and immobilization of urease from Momordica charantia seeds, Process Biochemistry, 2011, 46 , 1486-1491[*Corresponding authors; Publisher: Elsevier]

47. Abhay Narain Singh and Vikash Kumar Dubey*. Exploring applications of procerain B, a novel protease from Calotropis procera, and characterization by N-terminal sequencing as well as peptide mass fingerprinting. Applied Biochemistry and Biotechnology, 2011, 164, 573-80. [*Corresponding author; Publisher: Springer]

46. Anil K Shukla, Sanjukta Patra; Vikash Kumar Dubey*. Biophysical and folding parameters of trypanothione reductase from Leishmania infantum, Applied Biochemistry and Biotechnology, 2011, 165, 13-23 [*Corresponding author; Publisher: Springer]

45. Santhosh K. Venkatesan, Prakash Saudagar and Vikash Kumar Dubey*. Identification of novel inhibitor of Trypanothione synthtase from two Leishmania species: comparative in silico analysis. Journal of Proteins and Proteomics, 2011, 2, 41-48.

44. Neeraj Suthar and Vikash Kumar Dubey*. In silico approach to counter Leishmania donovani by targeting cysteine protease B : Structure modeling and inhibitor docking. Global Journal of Biochemistry,2011, 2, 49-58.

43. Santhosh K. Venkatesan, Prakash Saudagar, Anil Kumar Shukla and Vikash Kumar Dubey* Screening natural products database for identification of potential antileishmanial chemotherapeutic agents.Interdisciplinary Sciences: Computational Life Sciences, 2011, 3, 1-15 [*Corresponding author; Publisher: Springer]

42. Parameswaran Saravanan, Santhosh K. Venkatesan, C Gopi Mohan, Sanjukta Patra* and Vikash Kumar Dubey* Mitogen-activated protein kinase 4 of Leishmania parasite as a therapeutic target. European Journal of Medicinal Chemistry, 2010, 45, 5662-5670 [*Corresponding authors; Publisher: Elsevier]

41. Debamitra Chakravorty, Parameswaran Saravanan, Vikash Kumar Dubey and Sanjukta Patra. In Silico Characterization of Thermostable Lipases. Extremophiles, 2011, 15, 89-103 [Publisher: Springer].

40. Sushil Kumar Shakyawar, Arun Goyal, Vikash Kumar Dubey* Genome analysis of selected foodborne pathogens for identification of drug targets. Current Trends in Biotechnology and Pharmacy, 2011, 5, 1134-1148.

39. Sushil Kumar Shakyawar, Arun Goyal, Vikash Kumar Dubey* Database of in silico Predicted Potential Drug Target Proteins in Common Bacterial Human Pathogens. American Journal of Drug Discovery and Development, 2011, 1, 70-74.

38.B. Praveen Kumar#, Sushant Singh# and Vikash Kumar Dubey*. Effect of Arsenic stress on Vigna radiate: A Biochemical studies. International Journal of Environmental Science and Engineering Research. 2010. 1, 1-4 [#Equal contribution]

37. Parameswaran Saravanan, Vikash Kumar Dubey and Sanjukta Patra. In silico characterization of thermoactive, alkaline and detergent-stable lipase from a Staphylococcus aureus strain. In Silico Biology, 2010, 10, 265–276

36. Santhosh Kannan, Anil Kumar Shukla and Vikash Kumar Dubey*. Molecular docking studies of selected tricyclic and quinone derivatives on trypanothione reductase of Leishmania infantum. Journal of Computational Chemistry, 2010, 31, 2463-2472 [*Corresponding author; Publisher: Wiley InterScience] Research Highlight of the article published in Nature India.

35. Alka Dwevedi, Vikash Kumar Dubey, Medicherla V. Jagannadham, Arvind M. Kayastha (2010) Insights into pH-Induced Conformational transition of b-Galactosidase from Pisum sativum leading to its Multimerization. Applied Biochemistry and Biotechnology, 162, 2294-2312 [Publisher: Springer]

34. Abhay Narain Singh, Anil Kumar Shukla, M.V. Jagannadham and Vikash Kumar Dubey*. Purification of a novel cysteine protease, procerain B, from Calotropis procera with distinct characteristics compared to procerain. Process Biochemistry, 2010, 45, 399-406 [*Corresponding author; Publisher: Elsevier]

33. Nandini Sarkar and Vikash Kumar Dubey*. Protein nano-fibrilar structure and associated diseases. Current Proteomics, 2010, 7, 116-120. [*Corresponding author Publisher: Bentham Science]

32. Anil K Shukla, Bishal K Singh, Sanjukta Patra, Vikash Kumar Dubey.* Rational approaches for drug designing against leishmaniasis. Applied Biochemistry and Biotechnology, 2010, 160, 2208-2218 [*Corresponding author; Publisher: Springer]

31. Nandini Sarkar, Abhay Narain Singh and Vikash Kumar Dubey*. Effect of curcumin on amyloidogenic property of molten globule like intermediate state of 2,5-Diketo-D-Gluconate Reductase A. Biological Chemistry, 2009, 390, 1057-1061. [*Corresponding author; Publisher: Walter de Gruyter]

30. Neeraj Suthar, Arun Goyal and Vikash Kumar Dubey. Identification of potential drug targets of Leishmania Infantum by in-silico genome analysis. Letters in Drug Design and Discovery, 2009, 6, 620-622, [*Corresponding author; Publisher: Bentham Science]

29. Bishal Kumar Singh and Vikash Kumar Dubey*. In silico studies on tryparedoxin peroxidase of Leishmania infantum: Structural aspects. Current Pharmaceutical Biotechnology, 2009, 10, 626-630. [*Corresponding author Publisher: Bentham Science]

28. Syed Baquer Rizvi , Anil Kumar Shukla and Vikash Kumar Dubey.* A Simple method based on multiple alignment and phylogeny to derive a correlation between the protein fold and sequence via motif search. Interdisciplinary Sciences: Computational Life Sciences, 2009, 1, 235-243. [*Corresponding author; Publisher: Springer].

27. Nandini Sarkar Pramod Kumar Srivastava and Vikash Kumar Dubey*. Understanding the Language of Vitamin C. Current Nutrition & Food Science, 2009, 5, 53-55. [*Corresponding author; Publisher: Bentham Science]

26. Vikash Kumar Dubey*. Structural Genomics on Membrane Proteins. Applied Biochemistry and Biotechnology, 2009, 157, 111. [Corresponding author Publisher: Springer].

25. Anil Kumar Shukla, Utapl Bora and Vikash K. Dubey*. Functional Adaptations in Fibroblast Growth Factor (FGFs) Family. Journal of Proteins and Proteomics, 2009, 1, 11-13. [*Corresponding author; Publisher: Serial Publication (India)]

24. Naresh Kasoju , Shahin Sharif Ali, Vikash Kumar Dubey and Utpal Bora*. Exploiting the potential of Collagen as a Natural Biomaterial in Drug Delivery. Journal of Proteins and Proteomics, 2009, 1, 31-36 [Publisher: Serial Publication (India)]

23. Ritu Tomar, Vikash Kumar Dubey,* and M.V. Jagannadham* Biophysical characterization and folding studies of plant protease, Wrightin: identification folding intermediate under different conditions. The Protein Journal, 2009, 28:213-223 [*Co- corresponding author; Publisher: Springer]

22. Monu Pande, N K Prasanna Kumari, Vikash Kumar Dubey*, Pinky Tripathi, and M.V. Jagannadham*. Stability and Unfolding Studies on Alkaline Denatured State (Ip) of Pepsin. Process Biochemistry, 2009, 44, 906-911 [*Co-corresponding author; Publisher: Elsevier]

21. Ritu Tomar, Vikash Kumar Dubey, and M.V. Jagannadham* Effect of Alkyl Alcohols on partially unfolded state of Proteinase K: differential stability of alpha-helix and beta-sheet rich regions of the enzyme. Biochimie, 2009, 91, 951-960. [Publisher: Elsevier]

20. Bishal K. Singh, Nandini Sarkar, M.V. Jagannadham and Vikash K. Dubey*. Modeled Structure of Trypanothione Reductase of Leismania infantum. BMB Reports Previously known as J Biochem Mol Biol. And listed in journal citation report 2008 with old name), 2008, 41, 444-447. [*Corresponding author; Publisher: Korean Society of Biochemistry and Molecular Biology]

19. Vikash K Dubey* and M.V Jagannadham. Roles for cavities in protein structure: New insights. Current Proteomics, 2008, 5, 157-160 [*Corresponding author; Publisher: Bentham Science].

18. Bishal K. Singh, Nandini Sarkar and Vikash K. Dubey*. Modeled Structure of Trypanothione synthetase of Leishmania infantum for development of novel therapeutics for leishmaniasis. Current Trends in Biotechnology and Pharmacy, 2008, 2, 390-395. [*Corresponding author; Publisher: Association of Biotechnology and Pharmacy (India)]

17. Jihun Lee, Vikash K Dubey, Liam M Longo, Michael Blaber. Logical OR Redundancy within the Asx-Pro-Asx-Gly Type I b-turn Motif. Journal of Molecular Biology, 2008, 377, 1251-1264. [Publisher: Elsevier].

16. Vikash K. Dubey*, Bishal K Singh, Nandini Sarkar, Monu Pande and M.V Jagannadham. Biophysical characterization of Fibroblast Growth Factor homologous Factor-1b (FHF-1b): Sodium dodecyl sulfate promotes two state folding. Protein and Peptide Lett.,2008, 15, 215-218 [*Corresponding author;Publisher: Bentham Science]

15. Vikash K. Dubey*, Monu Pande, Bishal Kumar Singh and Medicherla V. Jagannadham. Realm of Papain-Like Proteases: Applications of their Inhibitors. Afr. Journal of Biotechnology, 2007, 6, 1077-1086. [*Corresponding author; Publisher: Academic Journals]

14. Vikash Kumar Dubey, Jihun Lee, Thayumana Somasundaram, Sachiko Blaber and Michael Blaber. Spackling the crack: stabilizing human fibroblast growth factor-1 by targeting the N- and C-termini b-strand interactions. Journal of Molecular Biology, 2007, 371, 256-268. [Publisher: Elsevier]

13. Sreedevi Nallamsetty, Vikash K. Dubey, Monu Pande, P. K. Ambasht and M.V. Jagannadham. Accumulation of partly folded states in the equilibrium unfolding of ervatamin A: Spectroscopic description of the native, intermediate, and unfolded states. Biochimie, 2007, 89, 1416-24. [Publisher: Elsevier;]

12. Monu Pande, Vikash Kumar Dubey, Vishal Sahu and M.V. Jagannadham. Conformational Plasticity of Cryptolepain: Accumulation of Partially Unfolded States in Denaturants induced Equilibrium Unfolding. Journal of Biotechnology, 2007, 131, 404-414. [Publisher: Elsevier]

11. Monu Pande, Vikash K. Dubey, and Medicherla V. Jagannadham. Crystallization and preliminary x-ray analysis of cryptolepain: A novel glycosylated serine protease from Cryptolepis buchanani. Acta Crystallographica, 2007, F63, 74-77 [Publisher: International Union of Crystallography;]

10. Jihun Lee, Vikash Kumar Dubey, Thayumanasamy Somasundaram and Michael Blaber. Conversion of type I 4:6 to 3:5 ?-turn types in human acidic fibroblast growth factor: Effects upon structure, stability, folding, and mitogenic function. Proteins: Structure Function Bioinformatics, 2006, 62, 686-697. [Publisher: Wiley InterScience]

9. Monu Pande, Vikash K. Dubey, Subhash Chandra Yadav and Medicherla V. Jagannadham. A Novel Serine Protease Cryptolepain, from Cryptolepis buchanani: Purification and Biochemical Characterization. Journal of Agricultural and Food Chemistry (ACS), 2006, 27, 10141-10150. [Publisher: American Chemical Society]

8. Vikash Kumar Dubey, Monu Pande and M.V. Jagannadham. Snapshots of Protein Folding Problem: Implications of Folding and Misfolding Studies. Protein and Peptide Lett., 2006, 13, 883- 888. [Publisher: Bentham Science].

7. Vikash K. Dubey, Ashu Saha, M.V. Jagannadham and A.M. Kayastha. Effect of Organic solvent on molten globule state of procerain: b-sheet to l-helix switchover in presence of TFE. Protein and Peptide Lett., 2006, 13, 545-547. [Publisher: Bentham Science]

6. Vikash K. Dubey, Jihun Lee, and Michael Blaber. Redesigning Symmetry-Related "Mini-Core" Regions of FGF-1 to Increase Primary Structure Symmetry: Thermodynamic and Functional Consequences of Structural Symmetry. Protein Science, 2005, 14, 2315-2323. [Publisher: Protein Society (USA)]

5. Carlo Travaglini-Allocatelli, Stefano Gianni, Vikash K. Dubey, Alessandro Borgia, Adele Di Matteo, Daniele Bonivento, Francesca Cutruzzola, Kara L. Bren, Maurizio Brunori. An obligatory intermediate in the folding pathway of cyctochrome C552 from Hydrogenobacter thermophilus. J. Biol Chem., 2005, 280, 25729-25734. [Publisher: American Society of Biochemistry and Molecular Biology].

4. Stephen R. Brych, Vikash K. Dubey, Ewa Bienkiewicz, Jihun Lee, Timothy M. Logan and Michael Blaber. Symmetric primary and tertiary structure mutations within a symmetric superfold: A solution and not a constraint to achieving a foldable polypeptide? Journal of Molecular Biology, 2004, 344, 769-780. [Publisher: Elsevier ]

3. Monica Sundd, Suman Kundu, Vikash Kumar Dubey and M.V. Jagannadham. Unfolding of ervatamin C in the presence of organic solvents: Sequential unfolding of the protein in O-state. Journal of Biochemistry and Molecular Biology, 2004, 37, 586-596. [Publisher:Korean Society of Biochemistry and Molecular Biology]

2. Vikash Kumar Dubey and M.V. Jagannadham. Differences in the unfolding of procerain induced by pH, GuHCl, urea and temperature. Biochemistry (ACS), 2003, 42, 12287-12297. [Publisher: American Chemical Society]

1. Vikash Kumar Dubey and M.V. Jagannadham. Procerain, a stable cysteine protease from Calotropis procera. Phytochemistry, 2003, 62, 1057-1071. [Publisher: Elsevier]

S.No.   Author/Co-authors Year of Title of Book(s)/ Book Chapters Details of Publisher
 
1 Bishal Kumar Singh and Vikash Kumar Dubey 2014 Leishmaniasis: Trypanothione metabolism as potential drug targets for rational drug designing (Chapter 20). In Recent Developments in Biotechnology (J.N. Govil Ed). Vol 9; pp 455-471  
Studium Press LLC, USA
ISBN: 1-62699-024-7
2 Vikash Kumar Dubey and Suman Kundu 2014 Processing of Recombinant Proteins (Chapter 34), In Gene and its Engineering. H. K. Das.Ed Wiley
ISBN: 978-81-265-4928-3
3 Ritesh Kumar, Shalini Singh and Vikash Kumar Dubey 2015 Bioinformatics Tools to Analyze Proteome and Genome Data, In: Advances in the Understanding of Biological Sciences Using Next Generation Sequencing (NGS) Approaches Editors: Sablok , G., Kumar , S., Ueno , S., Kuo , J., Varotto , C. Page 179-194 Springer
ISBN: 978-3-319-17157-9
4 Prepared 40 LECTURES online for National program for Enhanced learning (NPTEL), an initiative of IITs and IISc (funded by MHRD).http://nptel.ac.in/courses/102103017/
 
5 Database prepared: http://www.iitg.ac.in/vdubey/DTPdB/index.php

 

 

Year Title International/
National
Status
 
2013 Oxabicyclo derivatives as novel antileishmanial compound. (63/KOL/2013 ) National Published but award Pending
2012 Mutants of human fibroblast growth factor having increased stability and/or mitogenic potency . USA Patent issued [No. 8,119,776 (2012)] US patent/ International/ Awarded
2012 Mutants of human fibroblast growth factor having increased stability and/or mitogenic potency . USA Patent issued [No. 8,153,770 (2012)]. US patent/ International/ Awarded
2012 Mutants of human fibroblast growth factor having increased stability and/or mitogenic potency . USA Patent issued [No. 8,153,771 (2012)]. US patent/ International/ Awarded
2010 Iridoid glucosides from Nyctanthes arbortristis as new class of inhibitor of Trypanothion reductase of leishmania parasite. (306/KOL/2010). National Pending
2010 Mutants of human fibroblast growth factor having increased stability and/or mitogenic potency. USA Patent issued [No. 7,659,379 (2010)]. US patent/ International/ Awarded
2009 A novel cysteine protease, procerain B, from Calotropis procera. (1346/KOL/2009). National Pending
2009 Mutant polypeptides of Fibroblast Growth Factor-1. USA Patent issued [No. 7,595,296 (2009)]. US patent/ International/ Awarded
2010 Mutant polypeptides of Fibroblast Growth Factor-1. USA Patent issued [No. 7696171(2010)]. US patent/ International/ Awarded
2010 Mutant polypeptides of Fibroblast Growth Factor-1. USA Patent issued [No. 7776825 (2010)]. US patent/ International/ Awarded

After May 2018

1. Vikash Kumar Dubey, Understanding redox metabolism and host defence mechanism of Leishmani donovani for possible therapeutics. Invited Talk, Emerging Trends in Disease Model Systems, 25-27 March 2019, National Centre for Cell Sciences, Pune.

2. Gundappa Saha, Bakulesh M Khamar, Manish Kumar Vikash Kumar Dubey. Leishmani donovani  targets host proteins to alter the regulation of pyroptosis for their survival.  Emerging Trends in Disease Model Systems, 25-27 March 2019, National Centre for Cell Sciences, Pune (P-11). Selected among best posters presentations for Award

3. Gundappa Saha, Bakulesh M Khamar, Manish Kumar Vikash Kumar Dubey. Blimp-1 playing a role in the regulation of pyroptosis during Leishmani donovani infection. Recent Advancements in Biochemical Engineering and Biotechnology, 15-16 March 2019, IIT (BHU) Varanasi (AB-02). Poster  and Oral presentation by Gundappa Saha. Best oral presentation among young investigators

4. Kamalesh Verma, Lal Mohan Kundu and Vikash Kumar Dubey. Studies on stable azoreductase enzyme from Chromobacterium violaceum: application in industrial effluent dye degradation. Recent Advancements in Biochemical Engineering and Biotechnology, 15-16 March 2019, IIT (BHU) Varanasi (AB-05).

5. Adarsh Kumar Chiranjivi, Pranjal Chandra and Vikash Kumar Dubey. Site directed mutagenesis of Leishmani donovani  Dihydrolipoamide dehydrogenase to investigate role of Cysteine 38, Alanine 48, Aspartate 49 and Alanine 54 in regulation of catalytic activity. Recent Advancements in Biochemical Engineering and Biotechnology, 15-16 March 2019, IIT (BHU) Varanasi (AB-18).

Before May 2018
NOT UPDATED........

78. Kartikeya Tiwari and Vikash Kumar Dubey. Role of aspartate metabolism in the growth and infectivity of Leishmania donovani. 3rd International Conference on perspective of cell signaling and molecular medicine, 08-10 Jan 2016 at Bose Institute, Kolkata.

77. Kartikeya Tiwari and Vikash Kumar Dubey. Unraveling the role of L-asparaginase in the growth and infectivity of Leishmania donovani. 57 th Annual conference of Association of Microbiologists of India & International Symposium on Microbes and Biosphere: What's New What's Next, 24 -27 Nov, 2016 at Gauhati University. Assam, India

76. Kartikeya Tiwari and Vikash Kumar Dubey . Investigating pyrimidine metabolism of Leishmania donovani through dihydroorotase mediated inhibition. 9 th TCS Annual event and Flow Cytometry workshop on “Flow Application on Basic, Applied and Clinical Biology” (FABACTCS 2016), 03- 05 Nov, 2016 at IIT Guwahati, Guwahati. Assam, India.

75. Kartikeya Tiwari and Vikash Kumar Dubey . Exploring Leishmania donovani dihydroorotase as an effective drug target for antileishmanial therapy. Recent Developments In Medical Biotechnology And Structure Based Drug Designing (RDMBSBDD), 06-07 Dec 2015 at IIT Guwahati. Assam, India.

74. Ritesh Kumar and Vikash Kumar Dubey. Mechanistic elucidation of apoptosis in Leishmania : the important role of noncaspase proteases. 9 th TCS Annual event and Flow Cytometry workshop on “Flow Application on Basic, Applied and Clinical Biology” (FABACTCS 2016), 03- 05 Nov, 2016 at IIT Guwahati, Guwahati. Assam, India.

73. Ritesh Kumar and Vikash Kumar Dubey. Effect of TNP-470 on the apoptotic processes of miltefosine treated Leishmania donovani . 57 th Annual conference of Association of Microbiologists of India & International Symposium on Microbes and Biosphere: What's New What's Next, 24-27 Nov, 2016 at Gauhati University, Guwahati. Assam, India.

72. Ritesh Kumar and Vikash Kumar Dubey. Understanding the role of methionine aminopeptidase 2 in programmed cell death of Leishmania donovani by studying the knockout mutants. 3 rd International Conference on perspective of cell signaling and molecular medicine, 08-10 Jan 2016 at Bose Institute, Kolkata.

71. Prachi Bhalla, Anil Kumar Saikia and Vikash Kumar Dubey. Synthesis of second generation of Antileishmanial drugs. 9 th TCS Annual event and Flow Cytometry workshop on “Flow Application on Basic, Applied and Clinical Biology” (FABACTCS 2016), 03- 05 Nov, 2016 at IIT Guwahati, Guwahati. Assam, India.

70. Gundappa Saha, Bakulesh M Khamar and Vikash Kumar Dubey. Role of host Caspase 1 in the progression of Leishmania donovani infinfection. Cell Biology of Infection, October 13-14, 2016 at National Centre for Biological Sciences, TIFR, Bangalore, India.

69. Vikash Kumar Dubey. Recent development in Leishmania research: Promising drug candidates in pipeline. 8 th National symposia cum workshop on Recent Trends in Structural Bioinformatics and Computer Aided Drug Design 2016, February 16-19, 2016, Algappa University, Karaikudi[Invited talk].

68. Vikash Kumar Dubey. Admiring spermidine for its assorted functions: An integrated computational and Biochemical studies.. 7 th National symposia cum workshop on Recent Trends in Structural Bioinformatics and Computer Aided Drug Design 2015, February 24-27, 2015, Algappa University, Karaikudi[Invited talk].

67. Ruchika Bharadwaj and Vikash Kumar Dubey. “Investigating the role of a conserved hypothetical protein of Leishmania donovani “. 83 rd Annual Meeting of Society of Biological Chemists (SBCI), 17-21 December 2014, KIIT, Bhubaneswar.

  66. Shalini Singh, Mousumi Das, Ruchika Bhardwaj and Vikash Kumar Dubey. Is Spermidine Synthase only a redox enzyme in Leishmania donovani ? 83 rd Annual Meeting of Society of Biological Chemists (SBCI), 17-21 December 2014, IIT, Bhubaneswar.

65. Sushant Singh, Anil Verma and Vikash Kumar Dubey . Oxidative Stress Environment Superoxide Dismutase; A Novel Antioxidative Protein Alleviating The Oxidative Stress Environment. Sustainable Development of Environmental Systems. IIT Guwahati, June 20-21, 2014

64 Ritesh Kumar and Vikash Kumar Dubey. Exploring the world of proteases in search of caspase like activity in Leishmania donovani. International Conference on "Future Prospects of Advancements in Biological Sciences, Health Issues & Environmental Protection, 07 - 08 Feb, 2014 at Indira Gandhi Pratishthan, Lucknow . [ Best poster presentation Award].

63 Ankur Kumar, Shalini Singh, Mousumi Das, Vikash Kumar Dubey . Validation of CAAX prenyl protease as a novel drug target against leishmaniasis. International Conference on "Future Prospects of Advancements in Biological Sciences, Health Issues & Environmental Protection, 07 - 08 Feb, 2014 at Indira Gandhi Pratishthan, Lucknow .

62 Ashish Kumar Singh and Vikash Kumar Dubey. Glutamine Synthetase as a novel drug target against Leishmaniasis. International Conference on "Future Prospects of Advancements in Biological Sciences, Health Issues & Environmental Protection. 07 - 08 Feb, 2014 at Indira Gandhi Pratishthan, Lucknow .

60 Mousumi Das and Vikash Kumar Dubey. Exploring ornithine decarboxylase of Leishmania donovani for potential drug against leishmaniasis. International Conference on Health, Environment and Industrial Biotechnology BioSangam -2013. Allahabad, November 21 - 23, 2013. [Oral Presentation; Best oral presentation Award].

59. Shalini Singh, Mousumi Das, Ankur Kumar and Vikash Kumar Dubey. Over-expression, purification and characterization of CAAX prenyl protease I and CAAX prenyl protease II of Leishmania donovani . Indraprastha International Conference on Biotechnology (IICB-2013), October 22-25, 2013, New Delhi.

58. Shilpa N. Patere, Pankaj O. Pathak 1 , Mangal S Nagarsenke , Anil Kumar Shukla , Rajesh Kumar Singh Vikash Kumar Dubey and Dibyendu Bhattacharya. Surface modified liposomal formulation of Amphotericin B for treatment of visceral leishmaniasis . 6 th International Conference organized by SAC- ACCP on Innovations in 21 st century: Clinical Pharmacology in current and future environment, on 21 - 22 April 2013, Mumbai (India)

57. Vikash Kumar Dubey. Betraying the redox system for leishmania parasite. International Meeting on Emerging Diseases and Surveillance (IMED 2013). Vienna, Austria. February 15–18, 2013.

56. Prakash Saudagar and Vikash K. Dubey*. Oxabicyclo derivatives as a new class of antileishmanial agents:target identification and understanding molecular mechanism of parasite death. International Meeting on Emerging Diseases and Surveillance (IMED 2013). Vienna, Austria. February 15–18, 2013. [DST Travel Award].

55. Vikash Kumar Dubey. Discovery of novel anti-leishmanial compounds by targeting redox metabolism of the parasite: Integrated computational and Biochemicalapproaches. Workshop on “Basics of Molecular Modelling and Computer-Aided Drug Designing”. College of Veterinary Science, Assam Agricultural University, Guwahati, January 8-10, 2013 [Invited as resource person and delivered a lecture].

54. Vikash Kumar Dubey and Nandini Sarkar. Exploring possibility of promiscuity of amyloid inhibitors. International Interdisciplinary Science Conference 2012 on protein folding and Diseases. Jamia Milia Islamia University, New Delhi, December 8-10, 2012.

53. Sushant Singh and Vikash Kumar Dubey*. Biomarkers: effect of pollutants on biological systems. Quality improvement programme (QIP) on “Green Chemistry and Clean Technology”. Organized by the Centre for Environment, IIT Guwahati. Guwahati, November 26-28, 2012. [Oral presentation].

52. Vikash Kumar Dubey. The complexity in Biology derives from simple Biochemistry. 9th BRSI Convention & International Conference on Industrial Biotechnology, Punjabi University, Patiala, November 21-23, 2012 [Malviya Memorial Award (Young Faculty) lecture]. [Invited talk].

51. Sushant Singh, Abhay Narayan Singh, Anil Verma and Vikash Kumar Dubey*. Nanoencapsulating superoxide dismutase/catalase towards enhancing antioxidative defense against generated oxidative stress. 81st Annual Meeting of the Society of Biological Chemists (India) & Symposium on Chemistry and Biology: Two Weapons against Diseases. Science city, Kolkata. November 8-11, 2012.

50. Abhay Narayan Singh and Vikash Kumar Dubey*. Procerain B; an industrially important cysteine protease. 81st Annual Meeting of the Society of Biological Chemists (India) & Symposium on Chemistry and Biology: Two Weapons against Diseases. Science city, Kolkata. November 8-11, 2012.

49. Anil Kumar Shukla, Sanjukta Patra and Vikash Kumar Dubey*. Redox metabolism of Leishmania parasite: Ideal target for drug development against leishmaniasis, 15th International Congress on Infectious Diseases, Bangkok, Thailand, June 13-16, 2012 [Abstract No. 21.002. [Oral presentation].

48. Sushant Singh, Abhay Narayan Singh, Anil Verma and Vikash Kumar Dubey*. Response to metal stress in plant: Superoxide dismutase, its purification and characterization from Cicer arietinum L.seedlings. One day symposium on “Environment and Us”. IIT Guwahati, Guwahati. June 05, 2012.

47. Vikash Kumar Dubey. Fun with Flagellated parasite. Second National Conference on Biotechnology, Bioinformatics and Bioengineering. Kolhapur, Maharashtra, February 24-25, 2012. [Invited talk].

46. Vikash Kumar Dubey. Computer added drug designing: targeting redox metabolism of Leishmania parasite. Workshop on "Bioinformatics: Application in Agriculture and Medical Sciences. Banaras Hindu University, Varanasi. Feb. 16-18, 2012. [Invited talk].

45. Vikash Kumar Dubey. Application of Bioinformatics in Protein Sciences. Workshop on "Bioinformatics: Application in Agriculture and Medical Sciences. Banaras Hindu University, Varanasi. Feb. 16-18, 2012. [Invited talk].

44. Anil Kumar Shukla, Sanjukta Patra and Vikash Kumar Dubey*. Targeting redox system of Leishmania parasite for drug discovery.18th International Conference of ISCB-2012 at IASST, Guwahati, India, Jan. 28-30, 2012.

43. Manjeet Kumar and Vikash Kumar Dubey*. Quinacrine a potential biomarker to trace amyloid plaque: studies on A 40 peptide and hen egg white lysozyme amyloid as model system. Annual Meeting of Indian Biophysical Society, held at University of Madras, Chennai, India. January 19-21, 2012.

42. Saravanan P, Vikash Kumar Dubey and Sanjukta Patra. Potential inhibitors targeting LdLip3 to combat Leishmaniasis. Annual Meeting of the Indian Biophysical Society organized by University of Madras, Chennai, India. January 19-21, 2012.

41. Saudagar Prakash and Vikash Kumar Dubey*. Trypanothion synthetase: A validated drug target enzyme from Leishmania donovani. The 18th International Conference (POST ISCBC-2012) IASST Guwahati, Assam, India. January 28-30, 2012.

40. Abhay Narayan Singh and Vikash Kumar Dubey*. Procerain B: an industrially important cysteine protease; Purification, characterization and cloning. The 18th International Conference (POST ISCBC-2012) IASST Guwahati, Assam, India. January 28-30, 2012.

39. Saravanan P, Aviansh H, Vikash Kumar Dubey and Sanjukta Patra. Targeting essential cell wall lipase rv3802c to combat tuberculosis: homology modeling, virtual screening and comparative docking studies. Open Source Computer-Aided for Translational Medicine organized by IMTECH, Chandigarh, India. Febuary 22-25, 2012. [Oral presentation].

38. Vikash Kumar Dubey, Anil Kuamr Shukla and Prakash Saudagar Dubey. Current trends in anti-leishmanial drug discovery. International conference on New Horizones in Biotechnology, Trivandrum, India, November 21-24, 2011. [Invited talk].

37. Prakash Saudagar and Vikash Kumar Dubey*. Trypanothione Synthetase from L. donovani : Cloning, expression, characterization, and inhibition studies. 80th Annual Meeting of Society of Biological Chemists, held at Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow, India, November 12-15, 2011. [Best poster Award].

36. Prity Yadav, Abhay Narayan Singh and Vikash Kumar Dubey*. Heterologous expression of a novel plant cysteine protease: procerain B in E. coli and site directed mutagenesis to study the amino acids at catalytic triad. 80th Annual Meeting of Society of Biological Chemists, held at Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow, India, November 21-24, 2011. [Oral presentation].

35. Mousumi Das and Vikash Kumar Dubey*. Exploring ornithine decarboxylase for novel drugs against Leishmania donovani. 80th Annual Meeting of Society of Biological Chemists, held at Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow, India, November 12-15, 2011.

34. Manjeet Kumar and Vikash Kumar Dubey*. Quinacrine: as potential antemortem diagnostic dye for Alzheimer's disease. 80th Annual Meeting of Society of Biological Chemists, held at Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow, India, November 12-15, 2011.

33. Ruchika Bhardwaj, Anil Kumar Shukla and Vikash Kumar Dubey*. Synthesis of Chitosan-PEG coated Gold nanoparticles entrapping doxorubicin for evaluation of anti-leishmanial activity and targeted delivery to macrophage. 80th Annual Meeting of Society of Biological Chemists, held at Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow, India, November 12-15, 2011.

32. Shyamali Sarma and Vikash Kumar Dubey*. Cloning, expression and characterization of spermidine synthase, a drug target enzyme of Leishmania donovani. 80th Annual Meeting of Society of Biological Chemists, held at Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow, India, November 12-15, 2011.

31. Sushant Singh, Abhay Narayan Singh, Anil Verma, Vikash Kumar Dubey*. Heavy metal stress induced Superoxide dismutase: Purification and characterization from Cicer arietinum L. seedlings. 80th Annual Meeting of Society of Biological Chemists, held at Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow, India, November 12-15, 2011.

30. Abhay Narayan Singh and Vikash Kumar Dubey*. Physiochemical characterization, immobilization and cloning of procerain B: an industrially important plant cysteine protease. 80th Annual Meeting of Society of Biological Chemists, held at Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow, India, November 12-15, 2011.

29. Anil Kumar Shukla and Vikash Kumar Dubey. Synthesis of PEGylated nanospheres encapsulating doxorubicin and mitomycin C for their specific macrophage targeting, reduced toxicity and enhanced antileishmanial activity. 3rd EMBO meeting, Vienne, September 10-13, 2011. [DBT Travel Award].

28. Sushant Singh, Anil Verma and Vikash Kumar Dubey*. Effects of increasing Aluminium metal stress in germinating chickpea (Cicer arietinum) seeds. International Conference on Climate Change and Water: Assessing vulnerability, impact, and adaptation in the Eastern Himalayas. IIT Guwahati, Assam, January 3-5, 2011.

27. Abhay Narayan Singh and Vikash Kumar Dubey*. Procerain B a potential candidate for protease industry. World Congress on Biotechnology, Hyderabad, India, March 21-23, 2011.

26. Neha Sharma, Anil Kumar Shukla and Vikash Kumar Dubey*. Evaluation of Plumbagin and its derivative as potential modulator of Redox Thiol Metabolism of Leishmania parasite. World Congress on Biotechnology, Hyderabad, India, March 21-23, 2011.

25. Vikash Kumar Dubey, Subversive substrate of Trypanothione Reductase: a key for anti-leishmanial drug discovery. International conference on Genomics Science-Recent Trend (ICGS-2010). Madurai Kamraj University, Madurai, Nov. 12-14, 2010. [Special Invited talk as recipient of Young Scientist Award of Biotech Research Society].[Invited talk].

24. Vikash Kumar Dubey. Potential therapeutics against Leishmaniasis: Deciphering the molecular mechanism underlying the activity of antitumor agents as antileishmanial and their potential for therapy. National Conference on Biological Chemistry (NCBC-2010), Gitam Universuty, Visakhapatnam, November 29-30, 2010. [Invited talk].

23. S. Basak, Tushar, A. Das, V.K. Dubey and L. Rangan. Phylogenic analysis of Zingiberaceae native to Northeast India using RAPIS marker. International conference on Genomics Science-Recent Trend (ICGS-2010). Madurai Kamraj University, Madurai, Nov. 12-14, 2010.

22. Anil Kumar Shukla and Vikash Kumar Dubey*. Biophysical properties of TryR from Leishmania infantum: a step towards drug development for Leishmaniasis. International Conference on Frontiers on Biological Sciences. NIT, Rourkela. October 1-3, 2010.

21. Prakash Saudagar, Santhosh Kannan Venkatesan and Vikash Kumar Dubey* Molecular modeling, virtual screening and comparative analysis of. Trypanothione Synthetase from L. donovani and L. major for the identification of new inhibitors as a drug. International Conference on Frontiers on Biological Sciences. NIT, Rourkela. October 1-3, 2010. [Oral presentation].

20. Sushant Singh, Anil Verma and Vikash Kumar Dubey*. Oxidative stress analysis in germinated Chickpea seeds under copper ions. International Conference on Frontiers on Biological Sciences (INCOFIBS). NIT, Rourkela. October 1-3, 2010. [Oral presentation].

19. Anil Kumar Shukla and Vikash Kumar Dubey*. Molecular Mechanism underlying the Anti-leishmanial activity of Nyctanthes arbortristis. 4th International conference on 'Current trends in drug discovery research (CTDDR-2010). Central Drug Research Institute, Lucknow. February 17-21, 2010.

18. Nandini Sarkar and Vikash K. Dubey*. Effect of small molecule aggregators on amyloid formation of proteins. Symposium on Recent Trends in Biophysics. Organized Indian Biophysical Society, Banaras Hindu University, Varanasi, February 13-15, 2010.

17. Anil Kumar Shukla, Santhosh Kannan V. and Vikash Kumar Dubey*. Studies on Trypanothione Reductase from Leishmania infantum. 78th Annual Meeting of Society of Biological Chemists, India held at National Centre for Cell Science and University of Pune, Oct. 30-Nov. 1, 2009.

16. Santhosh Kannan V, Anil Kumar Shukla and Vikash Kumar Dubey*. Structure based virtual screening approach to identify potential inhibitors of Trypanothione reductase from Leishmania infantum. 78th Annual Meeting of Society of Biological Chemists, India held at National Centre for Cell Science and University of Pune, Oct. 30-Nov. 1, 2009.

15. Abhay Narain Singh, and Vikash Kumar Dubey*. Procerain B a novel cysteine protease from the latex of medicinal plant Calotropis procera. 78th Annual Meeting of Society of Biological Chemists, India held at National Centre for Cell Science and University of Pune, Oct. 30-Nov. 1, 2009.

14. Nandini Sarkar, Abhay Narain Singh, Vikash K. Dubey*. Identification of amyloidogenic folding intermediate state of 2,5-Diketo-D-Gluconate Reductase A: Effect of Curcumin on Amyloid formation.21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology held on 2-7 August 2009 and Young Scientist Program held on July30-August 2, 2009 in Shanghai, China. [The work was selected for IUBMB full travel fellowship funding and Young Scientist Program Award].

13. Abhay Narain Singh, Bishal Kumar Singh, and Vikash Kumar Dubey*. Drug designing against leishmaniasis by targeting parasite specific trypanothione metabolic pathway. NE Conference of Medical Microbiologysts-09. Guwahati Medical College Guwahati, April 24-26, 2009.

12. Nandini Sarkar, and Vikash Kumar Dubey*. Studies on 2,5 Diketo D Gluconate Reductase: Identification of Amyloid forming folding intermediate under acidic condition. 77th Annual Meeting of Society of Biological Chemists, India held at IIT Madras, Chennai December 18-20, 2008. [Received B.S Narasinga Rao Best Poster presentation Award].

11. Bishal Kumar Singh, and Vikash Kumar Dubey*. Structure of Trypanothione Reductase of Leishmania infantum: A therapeutic target for drug discovery. International conference on Biotechnology, Vellore Institute of Technology, India. February 6-8, 2008.

10. Jihun Lee, Vikash Dubey, L. Longo and Michael Blaber A Logical OR Redundancy within the Asx-Pro-Asx-Gly Type I b-turn Motif. 22nd Annual Symposium of The Protein Society. July 19-23, 2008 at the San Diego, California, USA. [Published in Protein Science, Vol 17, Suppl. 1, p232, 2008].

9. Vikash Kumar Dubey, Jihun Lee, Thayumanasamy Somasundaram and Michael Blaber. Stability, folding and functional consequences of imposed primary structure symmetry of FGF-1. Research Fair, College of Medicine, Florida State University, Tallahassee, USA, Feb., 28, 2006.

8. Jihun Lee, Vikash Kumar Dubey, and Michael Blaber. Effect of type I 3:5 G1 bulge ?-turn on protein stability and folding kinetics. Research Fair, College of Medicine, Florida State University, Tallahassee, USA, Feb., 28, 2006.

7. Vikash Kumar Dubey and Michael Blaber. Redesigning symmetry-related mini-core regions of FGF-1 to increase primary structure symmetry. 19th Annual Symposium of Protein Society. Boston, USA. July 29 - Aug. 3, 2005. [Published in Protein Science, Vol 14, Suppl. 1, p75, 2005].

6. Vikash K. Dubey, Stephen R. Brych, Jihun Lee, and Michael Blaber. Protein symmetry, stability and function, CALCON 2004 - the 59th Annual Calorimetry Conference, Santa Fe, New Mexico, USA, June 27 - July 1, 2004.

5. Carlo Travaglini-Allocatelli, Stefano Gianni, M.G. Bigotti Alessandro Borgia, Vikash K. Dubey, Francesca Cutruzzola and Maurizio Brunori. The folding landscape of cytochrome c family: tarps, intermediate and pathways. European Molecular Biology Organizations meeting on Protein folding and misfolding. Rome, Italy, April 3-5, 2003.

4. Vikash Kumar Dubey and M.V. Jagannadham. Equilibrium Unfolding of procerain: Sequential unfolding in molten globule like state. European Molecular Biology Organizations meeting on Protein folding and misfolding. Rome, Italy, April 3-5, 2003.

3. Vikash Kumar Dubey and M.V. Jagannadham. Procerain, a stable cysteine protease from Calotropis procera. International Symposium on Stabilization of Enzyme and Biosensors, Chennai, India. November 24-29, 2001.

2. Attended research scholars conference on Frontier areas of science, engineering and technology (VISION-2001) at Department of physics, Banaras Hindu University, Varanasi, India, May 6, 2001.

1. Vikash Kumar Dubey and M.V. Jagannadham. Cleavage of one specific disulfide bond of Ervatamin C. National Symposium on Biophysics, at Institute of Chemical Biology, Calcutta, India, January 15-17, 2001.

Sponsored Projects @ IIT (BHU) Varanasi (May 2018 onward..)
Sponsoring Organisation  Period  Title of Project  PI, /Co-PI
 CSIR  2019 - 2022  How Beclin 1 mediates cross-talk between apoptosis and autophagy via its C- terminal fragment?
Project approved: http://csirhrdg.res.in/SiteContent/ManagedContent/ContentFiles/20190412142442539rs_a19_medi.pdf
 P.I
IIT (BHU) Varanasi  2018-2019 Engineering recombinant human IL-2 fused Leishmanial surface antigens.  P.I

Sponsored Projects @ IIT Guwahati (2016-2018)

Sponsoring Organisation Period Title of Project PI, /Co-PI
 
DBT 2015-18
(Completed)
Unit of excellence in Molecular and Biochemical Parasitology: Investigation on evolutionary pressure for unique redox metabolism of Leishmania parasite PI
DBT 2015-17
(Completed)
 
Optimization of novel antileishmania scaffold 4-(4,4,8-Trimethyl-7-oxo-3-oxabicyclo[3.3.1]non-2-yl)-benzoic acid methyl ester, a oxabicyclo[3.3.1]nonanones: A mechanistic study PI
DBT 2017-2020
 
Understanding the mechanism of ABC-type metal sequestering proteins: structure-based novel drug development against human pathogens
Co-P.I
DBT 2014-2017
(Completed)
 
Identification of novel drug targets of Leishmania donovani: Studies on CAAX prenyl protease I and II of the pathogen PI
DBT 2012-2015
(Completed)
 
 
X-ray crystallographic structure elucidation of key drug target enzymes of Leishmania donovani. PI
DBT 2012-2015
(Completed)
 
Studies on trypanothione synthetase, a key enzyme of redox metabolism of Leishmania donovani. PI
DST 2012-2015
(Completed)
 
Variation in proteome profile of legume plants in response to heavy metal toxicity. PI
DBT 2011 – 2014
(Completed)
 
Betraying the parasite's redox system: Studies on spermidine synthase of Leishmania donovani PI
DBT 2011 - 2014
(Completed)
Studies on Peptide-conjugated nanoparticles mediated antileishmanial drug delivery to macrophages. PI
DBT 2010-2015
Extended for two years (2013-2015)
(Completed)
DBT-Innovative Young Scientist Award
Deciphering the molecular mechanism underlying the activity of antitumor agents as antileishmanial agents and their potential for therapy.
PI
ICMR 2011 - 2014
(Completed)
 
An integrated computational and biochemical approach to target ornithione decarboxylase, a key enzyme involved in synthesis of trypanothione for antileishmanial drug discovery. PI
CSIR 2009-2012
(Completed)
Studies on effect of small molecule compounds on folding and amyloid formation of proteins PI
DBT 2009-2012 (Completed)
 
Studies on Trypanothione Reductase from Parasites: Structure, Function, Folding and Potential for Chemotherapy PI
DIT 2008-2010 (Completed) Development of novel therapeutics against leishmaniasis. PI
DBT 2007-2010 (Completed) Folding Studies of 2, 5-Diketo-D-gluconate Reductase PI
DST 2007-2010 (Completed) Structural Properties and folding mechanism of apocytichrome C552 from Hydrogenobactor Thermophilus (DST-SERC FAST Young Scientist Grant PI
DBT 2010- DBT-Bioinformatics Infrastructure facility Co-Cordinator
DBT 2012-2015
(Completed)
Studies on structure of enzymes and their interaction with nanostructured materials for bioelectronics devices and other applications. CO-PI
DBT 2012-2015
(Completed)
Structural and functional studies of translation initiation factor from Pyrococcus horikoshii. CO-PI
DBT 2012-2015
(Completed)
Structure, Function, Dynamics and structural studies on Matrix metalloprotenases CO-PI
DIT 2007-2010 (Completed) Protein stability prediction of lipases – in silico studies CO-PI
DBT 2010-2013
(Completed)
Biochemical and Functional Characterization of RIO kinase (s) from as a potential drug target. CO-PI

Administrative experiences outside the Institute
-January 2019:  Board of studies, Chemical Technology, Guru Gobind Singh Indraprastha University, Delhi (two years from 16.01.2019)
-December 2018:  DBT-NER Technical Expert Committee (TEC) in the area of knowledge Generation and DISCOVERY Research, New Tool & Technology (three years from Dec. 2018)
-December 2018:  DBT-NER Scientific and Technical Appraisal and Advisory Group (STAGE)   (three years from Dec. 2018)
-August 2018: Subject Expert, Jharkhand Public Service Commission, Ranchi
-December 2018: Special Invitee, EMEQ Task Force Committee, SERB, Government of India
-July 2015 – May 2018:  DBT Nominee for Institutional Biosafety Committee, National Research Centre on Pig, Indian Council of Agricultural Research, Guwahati
-Member, Faculty selection, IIT, Central University and NIT
-Reviewed Research projects for Italian Ministry of Health; BIRAC, DBT, Govt of India; SERB, DST, Govt of India
-
Reviewed projects for Shastri Indo-Canadian Institute
-PhD thesis reviewer of several institutes including BHU, CDRI, NII, JNU, NEHU, IITs, NIPER, Utkal University etc
 
Administrative experiences at IIT (BHU) Varanasi (May 2018 onward)

-Associate Dean (Academic Affairs): 1-July 2019 onward
-Member, Library Committee (2018-2019)
-Member, Departmental Faculty Affairs Committee
-Member, Purchase committee (2018-19)
-Member, Department postgraduate Committee (DPGC).
-Member, Department undergraduate Committee (DUGC)
 
Administrative experiences at IIT Guwahati (September 2006 - May 2018)

Period Organisation Nature of Responsibility Designation
August 2015 – May 15, 2018 Centre for the Environment, IIT Guwahati Overall administration of the centre Head
December 2014 – November 2015 Student Welfare, IIT Guwahati Coordinating welfare activities of students Chairman
November 2014 – April 2017
 
Red Ribbon Club, IIT Guwahati HIV awareness among IIT Guwahati community Faculty In-Charge (Nodal Programme Officer), Red Ribbon Club
May 2009- May 2014 National Programme for Technology Enhanced Learning (NPTEL) Coordinating course development related to Biotechnology Coordinator (Biotechnology subject) National Programme for Technology Enhanced Learning
October 2007 to April 2009. Department of Biotechnology, IIT Guwahati All issues related to undergraduate courses of department Member, Department Undergraduate Programme Committee:
May 2009-May 2011 Department of Biotechnology, IIT Guwahati All issues related to undergraduate courses of department Member Secretary: Department Undergraduate Programme Committee
May 2009-May 2011 IIT Guwahati All issues related to undergraduate courses of the Institute Member, Institute Undergraduate Programme Committee (IUPC):
May 2011- May 2018 Department of Biotechnology, IIT Guwahati All issues related to undergraduate courses Member Department Undergraduate Programme Committee
December 2006 to April 2009. Department of Biotechnology, IIT Guwahati Writing all reports related to department Coordinator: Departmental report writing:
June 2012 -May 2013 Department of Biotechnology, IIT Guwahati Coordinating all equipment purchases for laboratory set-up Coordinator, Purchase committee for Equipment (Biotechnology)
June 2010-April 2011 Department of Biotechnology, IIT Guwahati Coordinating all issues related to space utilization, equipment purchases and repair Coordinator: Technical committee, Department of Biotechnology
March 2010-April 2012 Department of Chemical Engineering, IIT Guwahati All academics issue of Postgraduate students of the department External member, Department Postgraduate Programme Committee: (Dept. of Chemical Engineering, IITG):
May 2009 -May 2013 Department of Biotechnology, IIT Guwahati All academics issue of Postgraduate students of the department Member: Department Postgraduate Programme Committee
Sep. 2014-October 2015 IIT Guwahati Club Recreation and cultural activities of IIT Guwahati fraternity Vice President: IIT Guwahati Club
(IIT Guwahati director being President)
-Very actively involved in GATE examination (pre examination confidential duty and post examination duty.
-Member of various committees at IIT Guwahati (Campus well being committee; ant-ragging committee, convocation committee  etc)
-Member: Committee for space utilization: May 2013- May 2016
- Member: Technical committee, Department of Biotechnology : October 2007-May 2010.
- Member: Faculty recruitment Committee of the department: May 2009-May 2010.
- Faculty Advisor: 2005 B.Tech batch: October 2007- April 2009.
- Member: Purchase committee of the Department (2007-08).

 

 

               -Recent Advancements in Biochemical Engineering and Biotechnology (http://rabeb2019.iitbhu.ac.in/ ) March 15-16, 2019 at IIT (BHU) Varanasi
-

Recent Developments in Medical Biotechnology and Structure-Based Drug Designing   December 6th to 7th , 2015 (at IIT Guwahati)

        -Conference on Bioinformatics and Computer Aided Drug Design [CBCADD 2015] December 7th, 2015 (at IIT Guwahati)

            - Symposium cum Workshop on "Advances in Computational Biology and Computer Aided Drug Design"  June 24th to 26th, 2015 (at IIT Guwahati)

       -QIP SHORT-TERM COURSE on "Advances In Drug Discovery" ( 20th-24th July 2009) (at IIT Guwahati)

       -National Conference on recent Advancements in Environmental Research, June 4-5, 2016 (at IIT Guwahati)

       -Organized several events as member of organizing committee

Research Group at IIT (BHU) Varanasi: 
Dr. Sunita Yadav (Postdoctoral Fellow; NPDF)
Mr. Debanjan Kunau (PhD Student)
Ms. Kumari Prerna  (PhD Student)
Mr. Umesh Bhati (MTech student)

Note:  I am looking for self-motivated PhD candidates to join the group. Applicants for postdoctoral fellowship through external funding may also discuss about research interests .

Ongoing Students at IIT Guwahati

Mr. Adarsh Kumar Chiranjivi, PhD Student
Mr. Gundappa Saha, PhD Student (Prime Minister Doctoral Fellow)
Mr. Kamlesh Verma, PhD Student

Trained several postdocs, Research fellows, trainees etc
Completed PhD/MTech students  @ IIT Guwahati (14 PhD completed ; 15 MTech completed)

S.No. Name Year of Completion Title of Thesis
List of completed PhD students  (Completed 14)
  1.  
Dr. Nandini Sarkar
Placement after PhD:Assistant Professor, Dept. of Biotech. and Medical Engg., NIT Rourkela
2011 Studies on effect of small molecule compounds on protein folding misfolding and amyloidogenesis
  1.  
Dr. Anil Kumar Shukla
Placement after PhD : Postdoctoral Fellow, National Institutes of Health/NCI-Frederick, USA
2012 Targeting Redox Metabolism of Leishmania Parasite for Potential Chemotherapy of Leishmaniasis.
 
  1.  
Dr. Abhay Narain Singh
Placement after PhD : Postdoctoral Fellow, University of Oxford, United Kingdom
2013 Studies on Procerain-B, a Novel Cysteine Protease from Calotropis Procera
 
  1.  
Dr. Prakash Saudagar
Placement after PhD : Assistant Professor, Dept. of Biotechnology, NIT Warangal
2013 Insights into redox metabolism of Leishmania parasite: Studies on key enzymes for novel drug candidates.
  1.  
Dr. Sushant Singh
Placement after PhD : Postdoctoral Fellow, The Ohio State University, USA
2014 Studies on Superoxide Dismutase:  An antioxidative protein from Cicer arietinum L. seedlings
  1.  
Dr. S. Basak
Placement after PhD : Post doctoral Fellow, National Centre for Biological Sciences, Bangalore
2014 Molecular phylogeny of zingiberoideae
  1.  
Dr.Rohitas Deshmukh
Placement after PhD : Assistant Professor, Shri Shankaracharya Group of Institutions, Chattisgarh
2014 Investigation of Macrophage medicated homeostatsis during malaria
  1.  
Dr. P. Saravanan
Placement after PhD : Dr. D. S. Kothari Postdoctoral Fellowship , Anna University , Chennai
2014 Bioinformatics  approach to understand and exploit the potential of Lipases
  1.  
Dr. Mousumi Das 
Placement after PhD : Post doctoral fellow at Moffitt Cancer Center, Tampa, USA
2015 Studies on redox system of Leishmania donovani: Understanding drug resistance process and discovery of novel drug candidates.
  1.  
Dr. Shalinis Singh
Placement after PhD : Postdoctoral Fellow, University of Oxford, United Kingdom
2016 Studies on identification of novel drug targets and discovery of novel drug candidates by exploring Leishmania Biochemistry
  1.  
Dr. Ruchika Bhardwaj

Placement after PhD : National postdoctoral fellow at JNCASR, Bangalore

 

2016 Studies on identification and in vivo function of novel drug target enzymes of Leishmania donovani using biomolecular approaches
  1.  
Dr.Ritesh Kumar

Placement after PhD : Post doctoral Fellow, Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA.

 

2017 Exploring role of Methionine aminopeptidase 2 and other non-caspase proteases in program cell death of L. donovani
  1.  

Dr.Kartikeya Tiwari

Placement after PhD : Postdoctoral Fellow Indiana University School of Medicine , USA
 

2017 Physiological relevance of pyrimidine and aspartate metabolism in L. donovani through inhibition and knockout studies
  1.  

Dr.Shyalami Sarma

Placement after PhD : Postdoctoral Fellow IIT Bombay

 

2018 Biohydrogen production from Crude Glycerol: Process Optimization and Intensification
List of M.Tech students (Completed:  15)
  1.  
Ms. Aamen Talukdar 2018 Studies on Leishmania donovani theranostic
  1.  
Ms. Prachi Bhalla
Placement after M.Tech :
Research Fellow,
PGIMER, Chandigarh
 
2017 Synthesis of new oxabicyclic derivatives  and its evaluation as antileishmanial
  1.  
Ms. Sona Sharma
 
2016 Development of Novel antileishmanial compounds
  1.  
Ms. Ekta Kumari
Placement after M.Tech : Joining PhD, Technische Universitaet Dresden, Germany
2015 Integrated computational and Biochemical studies on Glutamine synthetase of Leishmania donovani
  1.  
Mr. Ashish Kumar Singh
Placement after M.Tech : PhD student,Ludwig-Maximilians-Universitat (LMU) Munich,Germany
2014 Studies on Glutamine Synthetase of Leishmania donovani
 
  1.  
Mr. Ankur Kumar
Placement after M.Tech : PhD Student, Indian Institute of Technology Delhi
2014 Studies on CAAX Prenyl protease I of Leishmania donovani
 
  1.  
Mr. Robin Sachdeva
Placement after M.Tech : PhD student, University of Heidelberg, Germany
2013

Studies on identification of novel drug target of Leishmania donovani

  1.  
Mr. Preet Lal
Placement after M.Tech : PhD Student, Universitá degli Studi di Trento, Italy
2013  
  1.  
Ms.Ruchika Bhardwaj
Placement after M.Tech : PhD student, Indian Institute of Technology Guwahati
2012 Synthesis of Chitosan reduced Gold nanoparticles associated doxorubicin for evaluation of anti-leishmanial activity
  1.  
Ms. Prity Yadav
Placement after M.Tech : PhD Student, National Institute of Immunology, New Delhi
2012 Soluble expression of procerain B in E.
  1.  
Ms. Neha Sharma
Placement after M.Tech : PhD student,Ludwig-Maximilians-Universitat (LMU) Munich,Germany
2011 Study on various potential modulators of Redox Metabolism of Leishmania parasite.
 
  1.  
Ms. Deblina Chakraborty
Placement after M.Tech : PhD student,Ludwig-Maximilians-Universitat (LMU) Munich,Germany
2011 Studies on CAAX prenyl protease I of Leishmania donovani
  1.  
Mr. B. Praveen Kumar
Placement after M.Tech : CCMB, Hyderabad
2010 Effect of heavy metals on plants
  1.  
Ms. Sumithra 2010  
  1.  
Mr. B. Leela Krishna
Placement after M.Tech : PhD student, Institute of Microbial Technology, Chandigarh
2010 Isolation and purification of urease from plant sources