Dr. Abha Mishra

Professor
Department/School/Unit Name
School of Biochemical Engineering IIT BHU
Phone No(s): 9451887940
Email: abham.bce@iitbhu.ac.in
Area of Interest: Drug Discovery and Development, Precision and Target Oncology, Fermentation Technology and Intellectual Property Rights (IPR).

[1] Raut, S.S., sharma, A., Mishra, P.K. et al. Isolation and characterization of novel bacterial strain from sewage sludge and exploring its potential for hydrogen production. Arch Microbiol 207, 10 (2025). https://doi.org/10.1007/s00203-024-04211-0

[2] Singh, V., Kumar, A., Mishra, V., & Rai, S.N. (Eds.). (2024). Heavy Metal Contamination in the Environment: Health Impacts and Potential Remediation Approaches (1st ed.). CRC Press. https://doi.org/10.1201/9781032685793

[3] Sharma, A., Raut, S.S., Shukla, A. Mishra, A. DDX3X dynamics, glioblastoma's genetic landscape, therapeutic advances, and autophagic interplay. Med Oncol 41, 258 (2024). https://doi.org/10.1007/s12032-024-02525-z

[4] Raut, S.S., Mishra, A. (2024). Gamma Radiation-Based Technologies for Waste Biomass Valorization: Mechanism, Instrument Design, Recent Technical Advances, Limitations, and Future Aspect. In: Verma, P., Kumar, B. (eds) Sustainable Radiation Technologies in Waste-biomass Valorization. Green Chemistry and Sustainable Technology. Springer, Cham. https://doi.org/10.1007/978-3-031-63941-8_10

[5] Sharma, A., Raut, S.S., Dhikale, P., Khushboo, Mishra, A. (2024). Navigating the Landscape of Cancer-Induced Thrombocytopenia: Current Challenges and Emerging Advances. In: Verma, P. (eds) Industrial Microbiology and Biotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-97-6270-5_14

[6] A. D. Tripathi, Y. Labh, S. Katiyar, A. K. Singh, V. K. Chaturvedi, and A. Mishra, “Folate-Mediated Targeting and Controlled Release: PLGA-Encapsulated Mesoporous Silica Nanoparticles Delivering Capecitabine to Pancreatic Tumor,” ACS Appl. Bio Mater., Mar. 2024, doi: 10.1021/acsabm.4c00019.

[7] Tripathi, A.D., Labh, Y., Katiyar, S. et al. Advancements in Nano-Mediated Biosensors: Targeting Cancer Exosome Detection. J Clust Sci 35, 2195–2212 (2024). https://doi.org/10.1007/s10876-024-02676-z

[8] A. D. Tripathi, V. K. Pandey, S. Katiyar, and A. Mishra, “The Emerging Role of Biosensors in the Identification, Characterization, and use of Natural Bioactive Compounds,” in Recent Advances in Biosensor Technology: Volume 2, Bentham Science Publishers, 2023, pp. 1–15. Accessed: Dec. 29, 2024. [Online]. Available: DOIhttps://doi.org/10.2174/97898151237391230101https://www.benthamdirect.com/content/books/9789815136418.chap1

[9] S. Katiyar, A. D. Tripathi, R. K. Singh, A. Kumar Chaurasia, P. K. Srivastava, and A. Mishra, “Graphene-silymarin-loaded chitosan/gelatin/hyaluronic acid hybrid constructs for advanced full-thickness burn wound management,” Int. J. Pharm., vol. 659, p. 124238, Jun. 2024, doi: 10.1016/j.ijpharm.2024.124238.

[10] Shukla, P., Srivastava, P. & Mishra, A. On the potential activity of hyaluronic acid as an antimicrobial agent: experimental and computational validations. Bioprocess Biosyst Eng (2024). https://doi.org/10.1007/s00449-024-03091-4

[11] Saini, R., Kumari, S., Bhatnagar, A. et al. Discovery of the allosteric inhibitor from actinomyces metabolites to target EGFRCSTMLR mutant protein: molecular modeling and free energy approach. Sci Rep 13, 8885 (2023). https://doi.org/10.1038/s41598-023-33065-7

[12] R. Saini, S. Kumari, A. Singh, and A. Mishra, “From nature to cancer therapy: Evaluating the Streptomyces clavuligerus secondary metabolites for potential protein kinase inhibitors,” J. Cell. Biochem., vol. 125, no. 1, p. e30501, 2024, doi: 10.1002/jcb.30501.

[13] Kumari, S., Saini, R., Bhatnagar, A., & Mishra, A. (2023). A comprehensive review on ayurvedic herb Leptadenia reticulata (Jeevanti): a phytochemistry and pharmacological perspective. Natural Product Research38(23), 4234–4260. https://doi.org/10.1080/14786419.2023.2282119

[14] Kumari, S., Saini, R., Bhatnagar, A., & Mishra, A. (2023). Exploring plant-based alpha-glucosidase inhibitors: promising contenders for combatting type-2 diabetes. Archives of Physiology and Biochemistry130(6), 694–709. https://doi.org/10.1080/13813455.2023.2262167

[15] A. D. Tripathi, S. Katiyar, and A. Mishra, “Glypican1: A potential cancer biomarker for nanotargeted therapy,” Drug Discov. Today, vol. 28, no. 8, p. 103660, Aug. 2023, doi: 10.1016/j.drudis.2023.103660.

[16] Soumya Katiyar1, Shikha Kumari2, Ritika Singh3, Abhay Dev Tripathi4, Divakar Singh5, Pradeep K. Srivastava6, Abha Mishra7, “Recent Advances in the Application of Nano-Biosensor in Tissue Engineering,” in Recent Advances in Biosensor Technology: Volume 1, Bentham Science Publishers, 2023, pp. 112–146. [Online]. Available: DOIhttps://doi.org/10.2174/97898151237391230101

[17] Shukla, P., Srivastava, P., Mishra, A. (2023). Hyaluronic Acid Microbial Synthesis and Its Explicit Uses in the Development of Nutraceuticals, Biomedicine, and Vaccine Development. In: Verma, P. (eds) Industrial Microbiology and Biotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-99-2816-3_13

[18] A. Bhatnagar and A. Mishra, “Development of Daruharidra (Berberis aristata) Based Biogenic Cadmium Sulfide Nanoparticles: Their Implementation as Antibacterial and Novel Therapeutic Agents against Human Breast and Ovarian Cancer,” http://www.eurekaselect.com, Accessed: Dec. 29, 2024. [Online]. Available: https://www.eurekaselect.com/article/136173

[19] A. Mishra and A. Bhatnagar, “23 - Green synthesis of nanoparticles by endophytes,” in Endophytic Association: What, Why and How, M. Shah and D. Deka, Eds., in Developments in Applied Microbiology and Biotechnology. , Academic Press, 2023, pp. 487–502. doi: 10.1016/B978-0-323-91245-7.00013-4.

[20] A. Bhatnagar, R. Saini, P. Dagar, and A. Mishra, “Molecular modelling and in vitro studies of Daruharidra as a potent alpha-amylase inhibitor,” J. Biomol. Struct. Dyn., vol. 41, no. 9, pp. 3872–3883, Jun. 2023, doi: 10.1080/07391102.2022.2058093.

[21] A. Bhatnagar, E. Tamboli, and A. Mishra, “Wastewater treatment and Mycoremediation by P. ostreatus mycelium,” IOP Conf. Ser. Earth Environ. Sci., vol. 775, no. 1, p. 012003, Jun. 2021, doi: 10.1088/1755-1315/775/1/012003.

Indo-US Conference on Bioengineering and Regenerative Medicine, ICBR-20,  27-29Feb, School of Biochemical Engineering, Organizing Secretary.

 

PG dissertation guided-55 Awarded; 04 ongoing

Ph.D.s- 09 as Supervisor (awarded); 03 submitted; 04 ongoing

Ph.D. students Co-guided: 09 (04 awarded; 05ongoing)

 

 

S.No.

Project title

Funding agency

Status (Ongoing/completed/ Submitted)

1.

Production of epsilon poly

lysine and its specific conjugates for

effective drug targeting,

DRDO

Completed

2.

Studies on production and

properties of glucoamylase by some new isolates of Aspergillus oryzae using agro-industrial waste in

solid state fermentation,

UGC

Completed

3.

Targeted drug delivery of methotrexate / gallic acid folate conjugated Poly L-Lysine nanoparticles

DBT

Completed (Sept 2018-Sept 2021)

4.

Transcriptome analysis of Cancer cell line treated with Gedunin and ZINC000045971961 as novel Bruton’s tyrosine kinase (BTK) inhibitor

LSRB, DRDO

Ongoing (June 2023- July 2026)

5.

Designing and fabrication of norfloxacin cunps and EGF loaded multilayered wound dressing for diabetic burn wound

CSIR

Ongoing (Sept 2024-Sept 2026)

6.

Development of a nanostructured graphene oxide/polydopamine coated nano-biosensor monitoring GPC1 for

the early diagnosis of pancreatic cancer,

ICMR

Ongoing (Nov 2024-Nov 2027)

S.No.

Student Name

Year of Joining

Designation

1.

Ravi Saini

2018

PhD

2.

Abhay Dev tripathi

2020

PhD

3.

Sonali Kumari

2020

PhD

4.

Shruti Raut

2023

PhD

5.

Arpit Sharma

2023

PhD

6.

Aishwarya Kesari

2024

PhD

7.

Dr. Alok Shukla

2024

RA

8.

Shivani Gupta

2024

Project-JRF

9.

Ravi

2024

PhD