jeyakumar.chy's picture
Dr. Jeyakumar Kandasamy
Associate Professor
Department of Chemistry, IIT-BHU
jeyakumar.chy@iitbhu.ac.in
9794516773
Area of Interest: 
Organic Chemistry, Carbohydrate Chemistry

Sureshbabu, P.; Azeez, S.; Muniyappan, N.; Sabiah, S.; Kandasamy, J.;* Chemo-Selective Synthesis of Aryl Ketones from Amides and Grignard Reagents via C(O)-N Bond Cleavage Under Catalyst-free Condition, J. Org. Chem, 2019, (accepted)

Singh, A. K.; Venkatesh, R.; Kandasamy, J.* Palladium-Catalyzed One-Pot Stereospecific Synthesis of 2-Deoxy Aryl C-Glycosides from Glycals and Anilines in the Presence of tert- Butyl Nitrite, Synthesis, 2019, (Accepted)

Allam, B. K.; Azeez, S.; Kandasamy, J.;* Nickel-Catalyzed Decarboxylative C–Si Bond Formation: A Regioselective Cross-Coupling Between Trialkyl Silanes and α,β-Unsaturated Carboxylic Acids, Appl.Organometal. Chem., 2019 (in press)

Gupta, S.; Baranwal,S.; Chaudhary, P.; Kandasamy, J.* Copper-promoted dehydrogenative cross-coupling reaction of dialkyl phosphites with sulfoximines, Org. Chem. Front., 2019, 6, 2260-2265.  

Mishra, K. B.; Kandasamy, J.* Tris(Pentafluorophenyl)Borane‐Driven Stereoselective O‐Glycosylation with Glycal Donors under Mild Condition, Asian J. Org. Chem. 2019, 8, 549– 554

Gupta, S.; Baranwal,S.; Muniyappan, N..; Sabiah, S.; Kandasamy, J.* Copper-catalyzed N-arylation of sulfoximines with arylboronic acid under mild Condition,  Synthesis , 2019, 51, 2171-2182
 
Sureshbabu, P.; Azeez, S.; Chaudhary, P.;   Kandasamy, J.*  tert-Butyl nitrite promoted transamidation of secondary amides under metal and catalyst free conditions, Org. Biomol. Chem. 2019 ,17, 845-850 

Chaudhary, P.; Gupta, S.; Muniyappan, N..; Sabiah, S.; Kandasamy, J.* Regioselective Nitration of N‑Alkyl Anilines using tert-Butyl Nitrite under Mild Condition,  J. Org. Chem. 2019, 84, 104-119 .

Geissner, A.; Reinhardt, A.; Rademacher, C.; Johannssen, T.; Monteiro, J.; Lepenies, B.; Thépaut, M.; Fieschi, F.; Mrázková, J.; Wimmerova, M.; Schuhmacher, F.; Götze, S.; Grünstein, D.; Guo, X.; Hahm, H. S.; Kandasamy J., Leonori, D.; Martin, C.; Parameswarappa, S. G.  Pasari, S.; Schlegel, M. K.; Tanaka, H.; Xiao, G.; Yang, Y.; Pereira, C. L. Anish , C.;  Seeberger, P. H. A microbe-focused glycan array screening platform, Proc. Natl. Acad. Sci. (USA), 2019, 116, 1958-1967.

Azeez, S.; Chaudhary, P.;  Sureshbabu, P.;  Sabiah, S.; Kandasamy, J.* tert-Butyl nitrite mediated nitrogen transfer reactions: Synthesis of benzotriazoles and azides at room temperature,  Org. Biomol. Chem. 2018, 16, 8280-8285.  

Azeez, S.; Chaudhary, P.;  Sureshbabu, P.;  Sabiah, S.; Kandasamy, J.* Potassium persulfate promoted N-nitrosation of secondary and tertiary amines with nitromethane under mild condition, Asian J. Org. Chem. 2018, 7, 2113-2119.

Singh, A. K.; Kandasamy J.*  Palladium catalyzed stereocontrolled synthesis of C-aryl glycosides using glycals and arenediazonium salts at room temperature, Org. Biomol. Chem. 2018, 16, 5107-5112.  

Tiwari, V.; Badavath,V. N.; Singh, A. K.; Kandasamy J.*  A highly efficient TEMPO mediated oxidation of sugar primary alcohols into uronic acids using 1-chloro-1,2-benziodoxol-3(1H)-one at room temperature, Tetrahedron Lett., 2018, 59, 2511-2514.

Mishra, K.B.; Singh, A. K.; Kandasamy J.* Tris(pentafluorophenyl)borane Promoted Stereoselective Glycosylation with Glycosyl Trichloroacetimidates under Mild Condition, J. Org. Chem2018, 83, 4204-4212.

Chauhan, S.; Chaudhary, P.; Singh, A. K.; Verma, P.; Srivastava, V.* ; Kandasamy, J.* tert-Butyl nitrite induced radical dimerization of primary thioamides and selenoamides at room temperature, Tetrahedron. Lett., 2018, 59, 272–276.

Chaudhary, P.; Korde, R.; Gupta, S.; Sureshbabu, P.; Sabiah, S.;, Kandasamy, J.* An efficient metal-free method for the denitrosation of aryl n-nitrosamines at room temperature, Adv. Synth. Catal. 2018, 360, 556–561.

Gupta, S.; Chaudhary, P.; Muniyappan, N..;  Sabiah, S.;  Kandasamy, J.* Copper promoted N-alkylation of sulfoximines with alkylboronic acid under mild conditions, Org. Biomol. Chem. 2017, 15, 8493-8498.

Singh, A. K.; Tiwari, V.; Mishra, K. B., Gupta S. and Kandasamy J.  Urea-hydrogen peroxide prompted selective and controlled oxidation of thioglycosides into Sulfoxides and Sulfones, Beilstein J. Org. Chem., 2017, 13, 1139–1144.

Gupta, S.; Sureshbabu, P.; Singh, A. K.;  Sabiah, S.;  Kandasamy, J.* Deoxygenation of tertiary amine N-oxides under metal free condition using phenylboronic acid, Tetrahedron. Lett., 2017, 58, 909-913.

Chaudhary, P.; Gupta, S.; Popuri, S.; Sabiah S.; Kandasamy, J.* A metal free reduction of aryl-N-nitrosamines to corresponding hydrazines using sustainable reductant thiourea dioxide, Green Chem., 2016, 18, 6215–6221.

Gupta, S.; Chaudhary, P.; Srivastava, V.; Kandasamy, J.* A chemoselective ipso-hydroxylation of arylboronic acids using urea-hydrogen peroxide under catalyst free condition,  Tetrahedron. Lett., 2016, 57, 2506–2510.

Chaudhary, P.; Gupta, S.; Muniyappan, N.; Sabiah S.; Kandasamy, J.* An efficient synthesis of N-nitrosamines under solvent, metal and acid free conditions using tert-butyl nitrite, Green Chem., 2016 18, 2323-2330.

Gupta, S.; Chaudhary, P.; Seva L.; Sabiah S.; Kandasamy, J.*  Bio-based green solvent for the catalyst free oxidation of arylboronic acids into phenols. RSC Adv., 2015, 5, 89133–89138.

Nonaka, M.; Bao, X. Matsumura, F.; Götze, S.; Kandasamy, J.; Broide, D. H.; Nakayama, J.; Seeberger, P. H.; Fukuda M. “An unusual di-sulfated Iduronic acid attenuates asthmatic response in mice by interfering chemokine-heparan sulfate-mediated T cell recruitment” Proc. Natl. Acad. Sci. (USA), 2014, 111, 8173-8178.      

Hurevich, M.;  Kandasamy, J.; Ponnappa, B. M.; Kopetzki,  D.; McQuade,  T.; Seeberger, P. H.Continuous Photochemical Cleavage of Linkers for Solid Phase Synthesis”, Org. Lett., 2014, 16, 1794–1797.   

Gunn, G.; Dai, Y.; Du, M.; Belakhov, V.; Kandasamy, J.; Schoeb, T.;  Baasov, T.; Bedwell,  D. “Long-Term Nonsense Suppression Therapy Moderates MPS I-H Disease Progression” Molecular Genetics and Metabolism, 2014, 111, 374-381. 

Kandasamy, J.; Schuhmacher, F.; Hahm, H.S.; Klein, J. C.; Seeberger, P. H. “Modular automated solid phase synthesis of dermatan sulfate oligosaccharides” Chem. Commun., 2014, 50, 1875-1877 . 

Kandasamy, J.; Hurevich, M.; Seeberger, P. H. “Automated solid phase synthesis of oligoarabinofuranosides”. Chem. Commun., 2013, 49, 4453-4455. (Cover Page)

Keeling, K.; Wang, D.; Dai, Y.; Srinivasan, M.; Chenna, B.; Clark, J.; Belakhov, V.; Kandasamy, J.; Velu, S.; Baasov, T.; Bedwell, D. “Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression”. PLoS One, 2013, 8, e60478.

Shalev, M.; Kandasamy, J.; Skalka, N.; Belakhov, V.; Rosin-Arbesfeld, R.; Baasov, T. “Development of generic immunoassay for the detection of a series of aminoglycosides with 6'-OH for the treatment of genetic diseases in biological samples”. J. Pharmaceut. Biomed. Anal. 2013, 75, 33-40.

Kandasamy, J.; Glikin, D.; Shulman, E.; Shapira, K.; Shavit, M.; Belakhov, V.; Baasov, T. “Increased selectivity towards cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: A strategy for treatment of genetic diseases caused by nonsense mutations”. J. Med. Chem. 2012, 55, 10630–10643.

Wang, D.; Belakhov, V.; Kandasamy, J.; Baasov, T.; Li, S-C.; Li, Y-T.; Bedwell, D. M.; Keeling K. M. “The designer aminoglycoside NB84 significantly attenuates biochemical defects associates with MPS I-H in the Idua-W392X mouse”. Molecular Genetics and Metabolism, 2012, 105, 116–125.

Kandasamy, J.; Glikin, D.; Belakhov, V.; Baasov, T. “Repairing faulty genes by aminoglycosides: Identification of new pharmacophore with enhanced suppression of diseases-causing nonsense mutations”. Med. Chem. Commun., 2011, 2, 165-171 (Highlighted in "RSC-Chemistry World" as HOT paper).

Pokrovskaya, V.; Nudelman, I.; Kandasamy, J.; Baasov, T. “Aminoglycosides: Redesign strategies for improved antibiotics and compounds for treatment of human genetic diseases”. Methods in Enzymology, 2010, 21, 437-462.

Jeyakumar, K.; Chakravarthy, R. D.; Chand, D. K. “Simple and efficient method for the oxidation of sulfides to sulfones using hydrogen peroxide and a Mo(VI) based catalyst”. Catal. Commun. 2009, 10, 1948-1941.

Jeyakumar, K.; Chand, D. K. “Application of molybdenum(VI) dichloride dioxide (MoO2Cl2) in organic transformations”. J. Chem. Sci. 2009, 121, 111-123.  [Highlighted in Cover Page].

Jeyakumar, K.; Chand, D. K. “Molybdenum(VI) dichloride dioxide catalyzed oxidation of β-hydroxycarbonyls to α-bromo 1,3-dicarbonyls by N-bromosuccinimide”. Synthesis, 2009, 306-310.

Jeyakumar, K.; Chand, D. K. “Molybdenum(VI)/copper(II)- An efficient bimetallic catalyst for aerobic oxidation of   alcohols”. Open Catal. J. 2008, 1, 6-11. [Invited article by the editor].

Jeyakumar, K.; Chand, D. K. “Molybdenum(VI) dichloride dioxide catalyzed synthesis  of β-ketoesters by C–H insertion of ethyl diazoacetate into aldehydes”. Synthesis, 2008, 1685-1687.

Jeyakumar, K.; Chand, D. K. “Ring opening reactions of epoxides catalyzed by molybdenum(VI) dichloride dioxide”. Synthesis, 2008, 807-819.

Jeyakumar, K.; Chand, D. K.  “Copper perchlorate: Efficient acetylation catalyst under solvent free conditions”. J. Mol. Catal. A: Chem. 2006, 255, 275-282.

Jeyakumar, K.; Chand, D. K. “Selective oxidation of sulfides to sulfoxides and sulfones at room temperature using H2O2 and a Mo(VI) salt as catalyst”. Tetrahedron Lett., 2006, 47, 4573-4576.  (> 85 times cited) 

Jeyakumar, K.; Chand, D. K. “Aerobic oxidation of benzyl alcohols by Mo (VI) compounds”. Appl. Organometal. Chem. 2006, 20, 840-844.

Chand, D. K.; Manivannan, R.; Sahoo, H. S.; Jeyakumar, K. “Self-assembly by ligand-exchange reactions”. Eur. J. Inorg. Chem. 2005, 3346–3352.

 

BOOK CHAPTER

Hurevich, M.; Kandasamy, J.; Seeberger, P. H. “Automated Techniques for Carbohydrate Synthesis”. in Glycochemical Synthesis: Strategies and Applications, 2016, (edited by Prof. Shang-Cheng Hung) (Publisher: Wiley)

Kandasamy J.; Sabiah, S. “Carbohydrates in drug discovery:  Insights into sulfated marine polysaccharides”. in Marine Glycobiology: Principles and Applications, 2016 (Edited by Prof. Se-Kwon Kim), CRC press Taylor & Francis, USA.

PATENT

Baasov, T.; Glikin, D.; Kandasamy, J.; Belakhov, V. “Preparation of aminoglycosides and uses thereof in treating genetic disorders and as antibacterial agents”. PCT Int. Appl. (2012), WO 2012066546 A1 20120524.

 

 

S. No. Name of the Student Year of registration Year of completion/progress Title of Thesis
1. Dr. Surabhi Gupta June 2014 Degree awarded in Dec 2018

Current position: Postdoc in Israel 

Applications of Boronic Acids As a Reagent and Starting Material In Organic Synthesis
2. Dr. Priyanka Chaudhary June 2014 Degree awarded in Dec 2018

Current position: Postdoc in S.Korea

Synthesis and Applications of N-Nitrosamines in Organic Syntheses
3. Mr. Adesh Kumar Singh 2015 In progress New glycosylation methods for carbohydrate synthesis
4. Ms. Varsha Tiwari 2016 In progress Syntheis and applications of uronic acids
5. Ms. Sadaf Siddiqui 2016 In progress Carboxylic acid as surrogates for organic synthesis
6 Mr. Sidharth Branwal 2017 In progress Sulfoximine Synthesis and applications
7 Mr. Vimleshkumar 2018 In progress Novel glycosylation methods for carbohydrate synthesis
8 Ms. Shweta Singh 2018 In progress Reaction Methodology
9 Mr. Venkatesh 2019 In progress Applications of aryl diazonium salts

 

Academic Profile

  • Ph.D. [with Prof. Dillip K. Chand]: IIT-Madras [2004-2008]
  • M.Sc.: University of Madras. [2003]
  • B.Sc.: A. A. G. A. College, Namakkal. [2000]

Professional Profile

  • Assistant Professor: Indian Institute of Technology (Banaras Hindu University) Varanasi [June 2014-Till date]
  • Post Doctoral Fellow [with Prof. Timor Baasov]: Technion-Israel Institute of Technology, Haifa, Israel [2008-2011]
  • Post Doctoral Fellow [with Prof. Peter. H. Seeberger]: Max Planck Institute of Colloids and Interfaces (MPIKG), Berlin, Germany [2012-2014]
  • Euroglycoscience Award: European young investigator workshop-France. 2011
  • Schulich Postdoctoral Fellowship (Technion, Israel): -Oct. 2008 -Sep-2011
  • Council of Scientific and Industrial Research (CSIR):- 2004 (CSIR-JRF&SRF)
  • Graduate Aptitude Test in Engineering (GATE): -2004 (95.01 percentile)
  • Topper in Comprehensive Exam in IITMadras-2005