jeyakumar.chy's picture
Dr. Jeyakumar Kandasamy
Assistant Professor
Department of Chemistry, IIT-BHU
jeyakumar.chy@iitbhu.ac.in
9794516773
Area of Interest: 
Organic Chemistry, Carbohydrate Chemistry

Mishra, K.B.; Singh, A. K.; Kandasamy J.* Tris(pentafluorophenyl)borane Promoted Stereoselective Glycosylation with Glycosyl Trichloroacetimidates under Mild Condition, J. Org. Chem. 2018 (in press)

Chauhan, S.; Chaudhary, P.; Singh, A. K.; Verma, P.; Srivastava, V.* ; Kandasamy, J.* tert-Butyl nitrite induced radical dimerization of primary thioamides and selenoamides at room temperature, Tetrahedron. Lett., 2018, 59, 272–276.

Chaudhary, P.; Korde, R.; Gupta, S.; Sureshbabu, P.; Sabiah, S.;, Kandasamy, J.* An efficient metal-free method for the denitrosation of aryl n-nitrosamines at room temperature, Adv. Synth. Catal. 2018, 360, 556–561.

Gupta, S.; Chaudhary, P.; Muniyappan, N..;  Sabiah, S.;  Kandasamy, J.* Copper promoted N-alkylation of sulfoximines with alkylboronic acid under mild conditions, Org. Biomol. Chem. 2017, 15, 8493-8498.

Singh, A. K.; Tiwari, V.; Mishra, K. B., Gupta S. and Kandasamy J.  Urea-hydrogen peroxide prompted selective and controlled oxidation of thioglycosides into Sulfoxides and Sulfones, Beilstein J. Org. Chem., 2017, 13, 1139–1144.

Gupta, S.; Sureshbabu, P.; Singh, A. K.;  Sabiah, S.;  Kandasamy, J.* Deoxygenation of tertiary amine N-oxides under metal free condition using phenylboronic acid, Tetrahedron. Lett., 2017, 58, 909-913.

Chaudhary, P.; Gupta, S.; Popuri, S.; Sabiah S.; Kandasamy, J.* A metal free reduction of aryl-N-nitrosamines to corresponding hydrazines using sustainable reductant thiourea dioxide, Green Chem., 2016, 18, 6215–6221.

Gupta, S.; Chaudhary, P.; Srivastava, V.; Kandasamy, J.* A chemoselective ipso-hydroxylation of arylboronic acids using urea-hydrogen peroxide under catalyst free condition,  Tetrahedron. Lett., 2016, 57, 2506–2510.

Chaudhary, P.; Gupta, S.; Muniyappan, N.; Sabiah S.; Kandasamy, J.* An efficient synthesis of N-nitrosamines under solvent, metal and acid free conditions using tert-butyl nitrite, Green Chem., 2016 18, 2323-2330.

Gupta, S.; Chaudhary, P.; Seva L.; Sabiah S.; Kandasamy, J.*  Bio-based green solvent for the catalyst free oxidation of arylboronic acids into phenols. RSC Adv., 2015, 5, 89133–89138.

Nonaka, M.; Bao, X. Matsumura, F.; Götze, S.; Kandasamy, J.; Broide, D. H.; Nakayama, J.; Seeberger, P. H.; Fukuda M. “An unusual di-sulfated Iduronic acid attenuates asthmatic response in mice by interfering chemokine-heparan sulfate-mediated T cell recruitment” Proc. Natl. Acad. Sci. (USA), 2014, 111, 8173-8178.      

Hurevich, M.;  Kandasamy, J.; Ponnappa, B. M.; Kopetzki,  D.; McQuade,  T.; Seeberger, P. H.Continuous Photochemical Cleavage of Linkers for Solid Phase Synthesis”, Org. Lett., 2014, 16, 1794–1797.   

Gunn, G.; Dai, Y.; Du, M.; Belakhov, V.; Kandasamy, J.; Schoeb, T.;  Baasov, T.; Bedwell,  D. “Long-Term Nonsense Suppression Therapy Moderates MPS I-H Disease Progression” Molecular Genetics and Metabolism, 2014, 111, 374-381. 

Kandasamy, J.; Schuhmacher, F.; Hahm, H.S.; Klein, J. C.; Seeberger, P. H. “Modular automated solid phase synthesis of dermatan sulfate oligosaccharides” Chem. Commun., 2014, 50, 1875-1877 . 

Kandasamy, J.; Hurevich, M.; Seeberger, P. H. “Automated solid phase synthesis of oligoarabinofuranosides”. Chem. Commun., 2013, 49, 4453-4455. (Cover Page)

Keeling, K.; Wang, D.; Dai, Y.; Srinivasan, M.; Chenna, B.; Clark, J.; Belakhov, V.; Kandasamy, J.; Velu, S.; Baasov, T.; Bedwell, D. “Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression”. PLoS One, 2013, 8, e60478.

Shalev, M.; Kandasamy, J.; Skalka, N.; Belakhov, V.; Rosin-Arbesfeld, R.; Baasov, T. “Development of generic immunoassay for the detection of a series of aminoglycosides with 6'-OH for the treatment of genetic diseases in biological samples”. J. Pharmaceut. Biomed. Anal. 2013, 75, 33-40.

Kandasamy, J.; Glikin, D.; Shulman, E.; Shapira, K.; Shavit, M.; Belakhov, V.; Baasov, T. “Increased selectivity towards cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: A strategy for treatment of genetic diseases caused by nonsense mutations”. J. Med. Chem. 2012, 55, 10630–10643.

Wang, D.; Belakhov, V.; Kandasamy, J.; Baasov, T.; Li, S-C.; Li, Y-T.; Bedwell, D. M.; Keeling K. M. “The designer aminoglycoside NB84 significantly attenuates biochemical defects associates with MPS I-H in the Idua-W392X mouse”. Molecular Genetics and Metabolism, 2012, 105, 116–125.

Kandasamy, J.; Glikin, D.; Belakhov, V.; Baasov, T. “Repairing faulty genes by aminoglycosides: Identification of new pharmacophore with enhanced suppression of diseases-causing nonsense mutations”. Med. Chem. Commun., 2011, 2, 165-171 (Highlighted in "RSC-Chemistry World" as HOT paper).

Pokrovskaya, V.; Nudelman, I.; Kandasamy, J.; Baasov, T. “Aminoglycosides: Redesign strategies for improved antibiotics and compounds for treatment of human genetic diseases”. Methods in Enzymology, 2010, 21, 437-462.

Jeyakumar, K.; Chakravarthy, R. D.; Chand, D. K. “Simple and efficient method for the oxidation of sulfides to sulfones using hydrogen peroxide and a Mo(VI) based catalyst”. Catal. Commun. 2009, 10, 1948-1941.

Jeyakumar, K.; Chand, D. K. “Application of molybdenum(VI) dichloride dioxide (MoO2Cl2) in organic transformations”. J. Chem. Sci. 2009, 121, 111-123.  [Highlighted in Cover Page].

Jeyakumar, K.; Chand, D. K. “Molybdenum(VI) dichloride dioxide catalyzed oxidation of β-hydroxycarbonyls to α-bromo 1,3-dicarbonyls by N-bromosuccinimide”. Synthesis, 2009, 306-310.

Jeyakumar, K.; Chand, D. K. “Molybdenum(VI)/copper(II)- An efficient bimetallic catalyst for aerobic oxidation of   alcohols”. Open Catal. J. 2008, 1, 6-11. [Invited article by the editor].

Jeyakumar, K.; Chand, D. K. “Molybdenum(VI) dichloride dioxide catalyzed synthesis  of β-ketoesters by C–H insertion of ethyl diazoacetate into aldehydes”. Synthesis, 2008, 1685-1687.

Jeyakumar, K.; Chand, D. K. “Ring opening reactions of epoxides catalyzed by molybdenum(VI) dichloride dioxide”. Synthesis, 2008, 807-819.

Jeyakumar, K.; Chand, D. K.  “Copper perchlorate: Efficient acetylation catalyst under solvent free conditions”. J. Mol. Catal. A: Chem. 2006, 255, 275-282.

Jeyakumar, K.; Chand, D. K. “Selective oxidation of sulfides to sulfoxides and sulfones at room temperature using H2O2 and a Mo(VI) salt as catalyst”. Tetrahedron Lett., 2006, 47, 4573-4576.  (> 85 times cited) 

Jeyakumar, K.; Chand, D. K. “Aerobic oxidation of benzyl alcohols by Mo (VI) compounds”. Appl. Organometal. Chem. 2006, 20, 840-844.

Chand, D. K.; Manivannan, R.; Sahoo, H. S.; Jeyakumar, K. “Self-assembly by ligand-exchange reactions”. Eur. J. Inorg. Chem. 2005, 3346–3352.

 

BOOK CHAPTER

Hurevich, M.; Kandasamy, J.; Seeberger, P. H. “Automated Techniques for Carbohydrate Synthesis”. in Glycochemical Synthesis: Strategies and Applications, 2016, (edited by Prof. Shang-Cheng Hung) (Publisher: Wiley)

Kandasamy J.; Sabiah, S. “Carbohydrates in drug discovery:  Insights into sulfated marine polysaccharides”. in Marine Glycobiology: Principles and Applications, 2016 (Edited by Prof. Se-Kwon Kim), CRC press Taylor & Francis, USA.

PATENT

Baasov, T.; Glikin, D.; Kandasamy, J.; Belakhov, V. “Preparation of aminoglycosides and uses thereof in treating genetic disorders and as antibacterial agents”. PCT Int. Appl. (2012), WO 2012066546 A1 20120524.

 

 

SNo

Name of the Research Student

Research Area

01

Ms. Surabhi Gupta

Organic reaction Methodology

02

Ms. Priyanka Chaudhary

Organic reaction Methodology

03

Mr. Adesh Kumar Singh

Carbohydrate Synthesis

04

Ms. Varsha Tiwari

Carbohydrate Synthesis

05

Ms. Sadaf Siddiqui

Organic reaction Methodology

Academic Profile

  • Ph.D. [with Prof. Dillip K. Chand]: IIT-Madras [2004-2008]
  • M.Sc.: University of Madras. [2003]
  • B.Sc.: A. A. G. A. College, Namakkal. [2000]

Professional Profile

  • Assistant Professor: Indian Institute of Technology (Banaras Hindu University) Varanasi [June 2014-Till date]
  • Post Doctoral Fellow [with Prof. Timor Baasov]: Technion-Israel Institute of Technology, Haifa, Israel [2008-2011]
  • Post Doctoral Fellow [with Prof. Peter. H. Seeberger]: Max Planck Institute of Colloids and Interfaces (MPIKG), Berlin, Germany [2012-2014]
  • Euroglycoscience Award: European young investigator workshop-France. 2011
  • Schulich Postdoctoral Fellowship (Technion, Israel): -Oct. 2008 -Sep-2011
  • Council of Scientific and Industrial Research (CSIR):- 2004 (CSIR-JRF&SRF)
  • Graduate Aptitude Test in Engineering (GATE): -2004 (95.01 percentile)
  • Topper in Comprehensive Exam in IITMadras-2005